Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda
Background: The prevalence of human papillomavirus (HPV) infections in other anatomical sites besides the uterine cervix is unknown in East Africa. Here, we assessed the prevalence and concordance of HPVs in different anatomical sites in HIV concordant couples in Rwanda. Methods: Fifty HIV-positive...
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MDPI AG
2023-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/4/1005 |
| _version_ | 1797603145589719040 |
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| author | Schifra Uwamungu Bethelehem Nigussie Claude Mambo Muvunyi Bengt Hasséus Maria Andersson Daniel Giglio |
| author_facet | Schifra Uwamungu Bethelehem Nigussie Claude Mambo Muvunyi Bengt Hasséus Maria Andersson Daniel Giglio |
| author_sort | Schifra Uwamungu |
| collection | DOAJ |
| description | Background: The prevalence of human papillomavirus (HPV) infections in other anatomical sites besides the uterine cervix is unknown in East Africa. Here, we assessed the prevalence and concordance of HPVs in different anatomical sites in HIV concordant couples in Rwanda. Methods: Fifty HIV-positive concordant male-female couples at the HIV clinic at the University Teaching Hospital of Kigali in Rwanda were interviewed, swabbed from the oral cavity (OC), oropharynx (OP), anal canal (AC), vagina (V), uterine cervix (UC) and penis. A pap smear test and a self-collected vaginal swab (Vself) were taken. Twelve high-risk (HR)-HPVs were analyzed. Results: HR-HPVs occurred in 10%/12% in OC, 10%/0% in OP and 2%/24% in AC (<i>p</i> = 0.002) in men and women, respectively. HR-HPVs occurred in 24% of UC, 32% of Vself, 30% of V and 24% of P samples. Only 22.2% of all HR-HPV infections were shared by both partners (κ −0.34 ± 0.11; <i>p</i> = 0.004). The type-specific HR-HPV concordance was significant between male to female OC-OC (κ 0.56 ± 0.17), V-VSelf (κ 0.70 ± 0.10), UC-V (κ 0.54 ± 0.13), UC-Vself (κ 0.51 ± 0.13) and UC-female AC (κ 0.42 ± 0.15). Conclusions: HPV infections are prevalent in HIV-positive couples in Rwanda but concordance within couples is low. Vaginal self-sampling for HPV is representative of cervical HPV status. |
| first_indexed | 2024-03-11T04:26:19Z |
| format | Article |
| id | doaj.art-93dc24912a994c2193d01533584f0445 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T04:26:19Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-93dc24912a994c2193d01533584f04452023-11-17T21:46:50ZengMDPI AGViruses1999-49152023-04-01154100510.3390/v15041005Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in RwandaSchifra Uwamungu0Bethelehem Nigussie1Claude Mambo Muvunyi2Bengt Hasséus3Maria Andersson4Daniel Giglio5Department of Pharmacology, Sahlgrenska Academy at the University of Gothenburg, SE-40530 Gothenburg, SwedenDepartment of Pathology, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, EthiopiaDepartment of Clinical Biology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali P.O. Box 3286, RwandaDepartment of Oral Medicine and Pathology, Institute of Odontology, Sahlgrenska Academy at the University of Gothenburg, P.O. Box 450, SE-40530 Gothenburg, SwedenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, SE-40530 Gothenburg, SwedenDepartment of Pharmacology, Sahlgrenska Academy at the University of Gothenburg, SE-40530 Gothenburg, SwedenBackground: The prevalence of human papillomavirus (HPV) infections in other anatomical sites besides the uterine cervix is unknown in East Africa. Here, we assessed the prevalence and concordance of HPVs in different anatomical sites in HIV concordant couples in Rwanda. Methods: Fifty HIV-positive concordant male-female couples at the HIV clinic at the University Teaching Hospital of Kigali in Rwanda were interviewed, swabbed from the oral cavity (OC), oropharynx (OP), anal canal (AC), vagina (V), uterine cervix (UC) and penis. A pap smear test and a self-collected vaginal swab (Vself) were taken. Twelve high-risk (HR)-HPVs were analyzed. Results: HR-HPVs occurred in 10%/12% in OC, 10%/0% in OP and 2%/24% in AC (<i>p</i> = 0.002) in men and women, respectively. HR-HPVs occurred in 24% of UC, 32% of Vself, 30% of V and 24% of P samples. Only 22.2% of all HR-HPV infections were shared by both partners (κ −0.34 ± 0.11; <i>p</i> = 0.004). The type-specific HR-HPV concordance was significant between male to female OC-OC (κ 0.56 ± 0.17), V-VSelf (κ 0.70 ± 0.10), UC-V (κ 0.54 ± 0.13), UC-Vself (κ 0.51 ± 0.13) and UC-female AC (κ 0.42 ± 0.15). Conclusions: HPV infections are prevalent in HIV-positive couples in Rwanda but concordance within couples is low. Vaginal self-sampling for HPV is representative of cervical HPV status.https://www.mdpi.com/1999-4915/15/4/1005human papillomavirusHIVmucous membranecervical cancerRwanda |
| spellingShingle | Schifra Uwamungu Bethelehem Nigussie Claude Mambo Muvunyi Bengt Hasséus Maria Andersson Daniel Giglio Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda Viruses human papillomavirus HIV mucous membrane cervical cancer Rwanda |
| title | Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda |
| title_full | Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda |
| title_fullStr | Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda |
| title_full_unstemmed | Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda |
| title_short | Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda |
| title_sort | prevalence of human papillomavirus in different mucous membranes in hiv concordant couples in rwanda |
| topic | human papillomavirus HIV mucous membrane cervical cancer Rwanda |
| url | https://www.mdpi.com/1999-4915/15/4/1005 |
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