Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human <it>Plasmodium </it>infection
<p>Abstract</p> <p>Background</p> <p>Polyclonal B-cell activation is well known to occur in <it>Plasmodium </it>infections, but its role in pathogenesis or protection remains unclear. However, protective properties of natural antibodies have previously been...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2005-01-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/4/1/5 |
| _version_ | 1819033584117219328 |
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| author | Fontes Cor Jesus F Coelho Alysson Silva Neto Adolfo Goulart Luis F Fesel Constantin Braga Erika M Vaz Nelson M |
| author_facet | Fontes Cor Jesus F Coelho Alysson Silva Neto Adolfo Goulart Luis F Fesel Constantin Braga Erika M Vaz Nelson M |
| author_sort | Fontes Cor Jesus F |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Polyclonal B-cell activation is well known to occur in <it>Plasmodium </it>infections, but its role in pathogenesis or protection remains unclear. However, protective properties of natural antibodies have previously been demonstrated in other contexts.</p> <p>Methods</p> <p>Sera from asymptomatic and symptomatic <it>Plasmodium</it>-infected subjects locally detected in a survey study in the Brazilian Amazon, and from unexposed and exposed but presently uninfected control subjects, were assayed by a standardized quantitative immunoblot method allowing simultaneous detection of IgG or IgM reactivity to a large number of parasite-unrelated proteins.</p> <p>Results</p> <p>In subjects free of coinfection with hepatitis B virus, IgG reactivity to human brain antigens and <it>Escherichia coli </it>proteins was strikingly enhanced in asymptomatic <it>Plasmodium</it>-infected individuals when compared to such with clinical malaria symptoms, or to uninfected control subjects. This difference was most characteristic for limited exposure times (less than ten years locally, or 20 years in endemic areas). It was more significant than a similar trend found for IgG to <it>Plasmodium falciparum </it>antigens, and unrelated to parasitaemia levels. Asymptomatic subjects with comparatively short exposure characteristically showed relatively elevated IgG versus IgM reactivity. Polyclonal IgG reactivity appears triggered by previous <it>P. falciparum </it>but not <it>Plasmodium vivax </it>malaria.</p> <p>Conclusion</p> <p>The observed difference in polyclonal antibody production seems related to intrinsic activation states of infected individuals, rather than to parasite-antigen specific immune responses. However, it appears influenced by preceding stimuli. This supports the idea that acquired clinical immunity may not exclusively depend on antigen-specific responses, but also on the individual polyclonal reaction.</p> |
| first_indexed | 2024-12-21T07:20:08Z |
| format | Article |
| id | doaj.art-93dc5c7d006d4a94a1f1a3d84acb2ca9 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-21T07:20:08Z |
| publishDate | 2005-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-93dc5c7d006d4a94a1f1a3d84acb2ca92022-12-21T19:11:48ZengBMCMalaria Journal1475-28752005-01-0141510.1186/1475-2875-4-5Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human <it>Plasmodium </it>infectionFontes Cor Jesus FCoelho AlyssonSilva Neto AdolfoGoulart Luis FFesel ConstantinBraga Erika MVaz Nelson M<p>Abstract</p> <p>Background</p> <p>Polyclonal B-cell activation is well known to occur in <it>Plasmodium </it>infections, but its role in pathogenesis or protection remains unclear. However, protective properties of natural antibodies have previously been demonstrated in other contexts.</p> <p>Methods</p> <p>Sera from asymptomatic and symptomatic <it>Plasmodium</it>-infected subjects locally detected in a survey study in the Brazilian Amazon, and from unexposed and exposed but presently uninfected control subjects, were assayed by a standardized quantitative immunoblot method allowing simultaneous detection of IgG or IgM reactivity to a large number of parasite-unrelated proteins.</p> <p>Results</p> <p>In subjects free of coinfection with hepatitis B virus, IgG reactivity to human brain antigens and <it>Escherichia coli </it>proteins was strikingly enhanced in asymptomatic <it>Plasmodium</it>-infected individuals when compared to such with clinical malaria symptoms, or to uninfected control subjects. This difference was most characteristic for limited exposure times (less than ten years locally, or 20 years in endemic areas). It was more significant than a similar trend found for IgG to <it>Plasmodium falciparum </it>antigens, and unrelated to parasitaemia levels. Asymptomatic subjects with comparatively short exposure characteristically showed relatively elevated IgG versus IgM reactivity. Polyclonal IgG reactivity appears triggered by previous <it>P. falciparum </it>but not <it>Plasmodium vivax </it>malaria.</p> <p>Conclusion</p> <p>The observed difference in polyclonal antibody production seems related to intrinsic activation states of infected individuals, rather than to parasite-antigen specific immune responses. However, it appears influenced by preceding stimuli. This supports the idea that acquired clinical immunity may not exclusively depend on antigen-specific responses, but also on the individual polyclonal reaction.</p>http://www.malariajournal.com/content/4/1/5 |
| spellingShingle | Fontes Cor Jesus F Coelho Alysson Silva Neto Adolfo Goulart Luis F Fesel Constantin Braga Erika M Vaz Nelson M Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human <it>Plasmodium </it>infection Malaria Journal |
| title | Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human <it>Plasmodium </it>infection |
| title_full | Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human <it>Plasmodium </it>infection |
| title_fullStr | Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human <it>Plasmodium </it>infection |
| title_full_unstemmed | Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human <it>Plasmodium </it>infection |
| title_short | Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human <it>Plasmodium </it>infection |
| title_sort | increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human it plasmodium it infection |
| url | http://www.malariajournal.com/content/4/1/5 |
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