The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study
Objectives: Synthetic MRI can obtain multiple parameters in one scan, including T1 and T2 relaxation time, proton density (PD), brain volume, etc. This study aimed to investigate the parameter values T1 and T2 relaxation time, PD, and volume characteristics of intraventricular hemorrhage (IVH) newbo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.721312/full |
| _version_ | 1818608112262709248 |
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| author | Chunxiang Zhang Chunxiang Zhang Xin Zhao Xin Zhao Meiying Cheng Meiying Cheng Kaiyu Wang Xiaoan Zhang Xiaoan Zhang |
| author_facet | Chunxiang Zhang Chunxiang Zhang Xin Zhao Xin Zhao Meiying Cheng Meiying Cheng Kaiyu Wang Xiaoan Zhang Xiaoan Zhang |
| author_sort | Chunxiang Zhang |
| collection | DOAJ |
| description | Objectives: Synthetic MRI can obtain multiple parameters in one scan, including T1 and T2 relaxation time, proton density (PD), brain volume, etc. This study aimed to investigate the parameter values T1 and T2 relaxation time, PD, and volume characteristics of intraventricular hemorrhage (IVH) newborn brain, and the ability of synthetic MRI parameters T1 and T2 relaxation time and PD to diagnose IVH.Materials and methods: The study included 50 premature babies scanned with conventional and synthetic MRI. Premature infants were allocated to the case group (n = 15) and NON IVH (n = 35). The T1, T2, PD values, and brain volume were obtained by synthetic MRI. Then we assessed the impact of IVH on these parameters.Results: In the posterior limbs of the internal capsule (PLIC), genu of the corpus callosum (GCC), central white matter (CWM), frontal white matter (FWM), and cerebellum (each p < 0.05), the T1 and T2 relaxation times of the IVH group were significantly prolonged. There were significant differences also in PD. The brain volume in many parts were also significantly reduced, which was best illustrated in gray matter (GM), cerebrospinal fluid and intracranial volume, and brain parenchymal fraction (BPF) (each p < 0.001, t = −5.232 to 4.596). The differential diagnosis ability of these quantitative values was found to be excellent in PLIC, CWM, and cerebellum (AUC 0.700–0.837, p < 0.05).Conclusion: The quantitative parameters of synthetic MRI show well the brain tissue characteristic values and brain volume changes of IVH premature infants. T1 and T2 relaxation times and PD contribute to the diagnosis and evaluation of IVH. |
| first_indexed | 2024-12-16T14:37:28Z |
| format | Article |
| id | doaj.art-93dcd0e7bd5f44908ba3b2398cee5d2b |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T14:37:28Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-93dcd0e7bd5f44908ba3b2398cee5d2b2022-12-21T22:28:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-09-011210.3389/fneur.2021.721312721312The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI StudyChunxiang Zhang0Chunxiang Zhang1Xin Zhao2Xin Zhao3Meiying Cheng4Meiying Cheng5Kaiyu Wang6Xiaoan Zhang7Xiaoan Zhang8Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaInstitute of Neuroscience, Zhengzhou University, Zhengzhou, ChinaDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaInstitute of Neuroscience, Zhengzhou University, Zhengzhou, ChinaDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaInstitute of Neuroscience, Zhengzhou University, Zhengzhou, ChinaGE Healthcare, MR Research China, Beijing, ChinaDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaInstitute of Neuroscience, Zhengzhou University, Zhengzhou, ChinaObjectives: Synthetic MRI can obtain multiple parameters in one scan, including T1 and T2 relaxation time, proton density (PD), brain volume, etc. This study aimed to investigate the parameter values T1 and T2 relaxation time, PD, and volume characteristics of intraventricular hemorrhage (IVH) newborn brain, and the ability of synthetic MRI parameters T1 and T2 relaxation time and PD to diagnose IVH.Materials and methods: The study included 50 premature babies scanned with conventional and synthetic MRI. Premature infants were allocated to the case group (n = 15) and NON IVH (n = 35). The T1, T2, PD values, and brain volume were obtained by synthetic MRI. Then we assessed the impact of IVH on these parameters.Results: In the posterior limbs of the internal capsule (PLIC), genu of the corpus callosum (GCC), central white matter (CWM), frontal white matter (FWM), and cerebellum (each p < 0.05), the T1 and T2 relaxation times of the IVH group were significantly prolonged. There were significant differences also in PD. The brain volume in many parts were also significantly reduced, which was best illustrated in gray matter (GM), cerebrospinal fluid and intracranial volume, and brain parenchymal fraction (BPF) (each p < 0.001, t = −5.232 to 4.596). The differential diagnosis ability of these quantitative values was found to be excellent in PLIC, CWM, and cerebellum (AUC 0.700–0.837, p < 0.05).Conclusion: The quantitative parameters of synthetic MRI show well the brain tissue characteristic values and brain volume changes of IVH premature infants. T1 and T2 relaxation times and PD contribute to the diagnosis and evaluation of IVH.https://www.frontiersin.org/articles/10.3389/fneur.2021.721312/fullsynthetic MRIintraventricular hemorrhagepremature infantsstrokebrain injury |
| spellingShingle | Chunxiang Zhang Chunxiang Zhang Xin Zhao Xin Zhao Meiying Cheng Meiying Cheng Kaiyu Wang Xiaoan Zhang Xiaoan Zhang The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study Frontiers in Neurology synthetic MRI intraventricular hemorrhage premature infants stroke brain injury |
| title | The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study |
| title_full | The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study |
| title_fullStr | The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study |
| title_full_unstemmed | The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study |
| title_short | The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study |
| title_sort | effect of intraventricular hemorrhage on brain development in premature infants a synthetic mri study |
| topic | synthetic MRI intraventricular hemorrhage premature infants stroke brain injury |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.721312/full |
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