Effect of age and disease on bone mass in Japanese patients with schizophrenia
<p>Abstract</p> <p>Background</p> <p>There have been a limited number of studies comparing bone mass between patients with schizophrenia and the general population. The aim of this study was to compare the bone mass of schizophrenia patients with that of healthy subject...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-02-01
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| Series: | Annals of General Psychiatry |
| Subjects: | |
| Online Access: | http://www.annals-general-psychiatry.com/content/11/1/5 |
| _version_ | 1819034048516849664 |
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| author | Sugawara Norio Yasui-Furukori Norio Umeda Takashi Tsuchimine Shoko Fujii Akira Sato Yasushi Saito Manabu Furukori Hanako Danjo Kazuma Matsuzaka Masashi Takahashi Ippei Kaneko Sunao |
| author_facet | Sugawara Norio Yasui-Furukori Norio Umeda Takashi Tsuchimine Shoko Fujii Akira Sato Yasushi Saito Manabu Furukori Hanako Danjo Kazuma Matsuzaka Masashi Takahashi Ippei Kaneko Sunao |
| author_sort | Sugawara Norio |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>There have been a limited number of studies comparing bone mass between patients with schizophrenia and the general population. The aim of this study was to compare the bone mass of schizophrenia patients with that of healthy subjects in Japan.</p> <p>Methods</p> <p>We recruited patients (n = 362), aged 48.8 ± 15.4 (mean ± SD) years who were diagnosed with schizophrenia or schizoaffective disorder based on the <it>Diagnostic and Statistical Manual of Mental Disorders</it>, fourth edition (DSM-IV). Bone mass was measured using quantitative ultrasound densitometry of the calcaneus. The osteosono-assessment index (OSI) was calculated as a function of the speed of sound and the transmission index. For comparative analysis, OSI data from 832 adults who participated in the Iwaki Health Promotion Project 2009 was used as representative of the general community.</p> <p>Results</p> <p>Mean OSI values among male schizophrenic patients were lower than those in the general population in the case of individuals aged 40 and older. In females, mean OSI values among schizophrenic patients were lower than those in the general community in those aged 60 and older. In an analysis using the general linear model, a significant interaction was observed between subject groups and age in males.</p> <p>Conclusions</p> <p>Older schizophrenic patients exhibit lower bone mass than that observed in the general population. Our data also demonstrate gender and group differences among schizophrenic patients and controls with regard to changes in bone mass associated with aging. These results indicate that intervention programs designed to delay or prevent decreased bone mass in schizophrenic patients might be tailored according to gender.</p> |
| first_indexed | 2024-12-21T07:27:32Z |
| format | Article |
| id | doaj.art-93dd0ea9055c4433a4852e4d4907ee90 |
| institution | Directory Open Access Journal |
| issn | 1744-859X |
| language | English |
| last_indexed | 2024-12-21T07:27:32Z |
| publishDate | 2012-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of General Psychiatry |
| spelling | doaj.art-93dd0ea9055c4433a4852e4d4907ee902022-12-21T19:11:38ZengBMCAnnals of General Psychiatry1744-859X2012-02-01111510.1186/1744-859X-11-5Effect of age and disease on bone mass in Japanese patients with schizophreniaSugawara NorioYasui-Furukori NorioUmeda TakashiTsuchimine ShokoFujii AkiraSato YasushiSaito ManabuFurukori HanakoDanjo KazumaMatsuzaka MasashiTakahashi IppeiKaneko Sunao<p>Abstract</p> <p>Background</p> <p>There have been a limited number of studies comparing bone mass between patients with schizophrenia and the general population. The aim of this study was to compare the bone mass of schizophrenia patients with that of healthy subjects in Japan.</p> <p>Methods</p> <p>We recruited patients (n = 362), aged 48.8 ± 15.4 (mean ± SD) years who were diagnosed with schizophrenia or schizoaffective disorder based on the <it>Diagnostic and Statistical Manual of Mental Disorders</it>, fourth edition (DSM-IV). Bone mass was measured using quantitative ultrasound densitometry of the calcaneus. The osteosono-assessment index (OSI) was calculated as a function of the speed of sound and the transmission index. For comparative analysis, OSI data from 832 adults who participated in the Iwaki Health Promotion Project 2009 was used as representative of the general community.</p> <p>Results</p> <p>Mean OSI values among male schizophrenic patients were lower than those in the general population in the case of individuals aged 40 and older. In females, mean OSI values among schizophrenic patients were lower than those in the general community in those aged 60 and older. In an analysis using the general linear model, a significant interaction was observed between subject groups and age in males.</p> <p>Conclusions</p> <p>Older schizophrenic patients exhibit lower bone mass than that observed in the general population. Our data also demonstrate gender and group differences among schizophrenic patients and controls with regard to changes in bone mass associated with aging. These results indicate that intervention programs designed to delay or prevent decreased bone mass in schizophrenic patients might be tailored according to gender.</p>http://www.annals-general-psychiatry.com/content/11/1/5bone massJapaneseschizophreniaultrasound |
| spellingShingle | Sugawara Norio Yasui-Furukori Norio Umeda Takashi Tsuchimine Shoko Fujii Akira Sato Yasushi Saito Manabu Furukori Hanako Danjo Kazuma Matsuzaka Masashi Takahashi Ippei Kaneko Sunao Effect of age and disease on bone mass in Japanese patients with schizophrenia Annals of General Psychiatry bone mass Japanese schizophrenia ultrasound |
| title | Effect of age and disease on bone mass in Japanese patients with schizophrenia |
| title_full | Effect of age and disease on bone mass in Japanese patients with schizophrenia |
| title_fullStr | Effect of age and disease on bone mass in Japanese patients with schizophrenia |
| title_full_unstemmed | Effect of age and disease on bone mass in Japanese patients with schizophrenia |
| title_short | Effect of age and disease on bone mass in Japanese patients with schizophrenia |
| title_sort | effect of age and disease on bone mass in japanese patients with schizophrenia |
| topic | bone mass Japanese schizophrenia ultrasound |
| url | http://www.annals-general-psychiatry.com/content/11/1/5 |
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