A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
Abstract Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrame...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SciELO
2022-03-01
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| Series: | Journal of Venomous Animals and Toxins including Tropical Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992022000100306&tlng=en |
| _version_ | 1828911837209427968 |
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| author | Mackson Martins Rocha Isabela Dariva Gabriela Comelli Zornoff Giovanna Sanches De Laurentis Giulia Carli Mendes Maycon Giovani Santana Guilherme Chohfi de Miguel Rui Seabra Ferreira Junior Juliana Mozer Sciani Denise Gonçalves Priolli |
| author_facet | Mackson Martins Rocha Isabela Dariva Gabriela Comelli Zornoff Giovanna Sanches De Laurentis Giulia Carli Mendes Maycon Giovani Santana Guilherme Chohfi de Miguel Rui Seabra Ferreira Junior Juliana Mozer Sciani Denise Gonçalves Priolli |
| author_sort | Mackson Martins Rocha |
| collection | DOAJ |
| description | Abstract Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the bone metastasis skeletal-related impact in colorectal cancer patients with bone metastasis. |
| first_indexed | 2024-12-13T19:10:36Z |
| format | Article |
| id | doaj.art-93ddaeb5da834163bdad2a4f218f16c2 |
| institution | Directory Open Access Journal |
| issn | 1678-9199 |
| language | English |
| last_indexed | 2024-12-13T19:10:36Z |
| publishDate | 2022-03-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Venomous Animals and Toxins including Tropical Diseases |
| spelling | doaj.art-93ddaeb5da834163bdad2a4f218f16c22022-12-21T23:34:26ZengSciELOJournal of Venomous Animals and Toxins including Tropical Diseases1678-91992022-03-012810.1590/1678-9199-jvatitd-2021-0067A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittinMackson Martins RochaIsabela DarivaGabriela Comelli ZornoffGiovanna Sanches De LaurentisGiulia Carli MendesMaycon Giovani Santanahttps://orcid.org/0000-0003-2084-668XGuilherme Chohfi de MiguelRui Seabra Ferreira Juniorhttps://orcid.org/0000-0001-6952-0512Juliana Mozer Scianihttps://orcid.org/0000-0001-7213-206XDenise Gonçalves Priollihttps://orcid.org/0000-0003-3190-4013Abstract Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the bone metastasis skeletal-related impact in colorectal cancer patients with bone metastasis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992022000100306&tlng=enBone metastasisMelittinIntratumoral injectionColorectal neoplasmsBee venom |
| spellingShingle | Mackson Martins Rocha Isabela Dariva Gabriela Comelli Zornoff Giovanna Sanches De Laurentis Giulia Carli Mendes Maycon Giovani Santana Guilherme Chohfi de Miguel Rui Seabra Ferreira Junior Juliana Mozer Sciani Denise Gonçalves Priolli A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin Journal of Venomous Animals and Toxins including Tropical Diseases Bone metastasis Melittin Intratumoral injection Colorectal neoplasms Bee venom |
| title | A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
| title_full | A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
| title_fullStr | A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
| title_full_unstemmed | A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
| title_short | A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
| title_sort | new therapeutic approach for bone metastasis in colorectal cancer intratumoral melittin |
| topic | Bone metastasis Melittin Intratumoral injection Colorectal neoplasms Bee venom |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992022000100306&tlng=en |
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