Reduced chromatin accessibility correlates with resistance to Notch activation
Notch signalling plays a key role in cell fate transitions, but how Notch activates distinct regulatory networks in closely related cell types is not well understood. Here the authors profile Notch and RBPJ targets in the developing mouse cortex and reveal how transcription factor occupancy and chro...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29834-z |
| _version_ | 1811289238094741504 |
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| author | Jelle van den Ameele Robert Krautz Seth W. Cheetham Alex P. A. Donovan Oriol Llorà-Batlle Rebecca Yakob Andrea H. Brand |
| author_facet | Jelle van den Ameele Robert Krautz Seth W. Cheetham Alex P. A. Donovan Oriol Llorà-Batlle Rebecca Yakob Andrea H. Brand |
| author_sort | Jelle van den Ameele |
| collection | DOAJ |
| description | Notch signalling plays a key role in cell fate transitions, but how Notch activates distinct regulatory networks in closely related cell types is not well understood. Here the authors profile Notch and RBPJ targets in the developing mouse cortex and reveal how transcription factor occupancy and chromatin remodelling interact to direct differential gene expression during differentiation. |
| first_indexed | 2024-04-13T03:51:23Z |
| format | Article |
| id | doaj.art-93dff00102e946c68df70fd26447e0de |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T03:51:23Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-93dff00102e946c68df70fd26447e0de2022-12-22T03:03:49ZengNature PortfolioNature Communications2041-17232022-04-0113111010.1038/s41467-022-29834-zReduced chromatin accessibility correlates with resistance to Notch activationJelle van den Ameele0Robert Krautz1Seth W. Cheetham2Alex P. A. Donovan3Oriol Llorà-Batlle4Rebecca Yakob5Andrea H. Brand6The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of CambridgeThe Gurdon Institute and Department of Physiology, Development and Neuroscience, University of CambridgeThe Gurdon Institute and Department of Physiology, Development and Neuroscience, University of CambridgeThe Gurdon Institute and Department of Physiology, Development and Neuroscience, University of CambridgeThe Gurdon Institute and Department of Physiology, Development and Neuroscience, University of CambridgeThe Gurdon Institute and Department of Physiology, Development and Neuroscience, University of CambridgeThe Gurdon Institute and Department of Physiology, Development and Neuroscience, University of CambridgeNotch signalling plays a key role in cell fate transitions, but how Notch activates distinct regulatory networks in closely related cell types is not well understood. Here the authors profile Notch and RBPJ targets in the developing mouse cortex and reveal how transcription factor occupancy and chromatin remodelling interact to direct differential gene expression during differentiation.https://doi.org/10.1038/s41467-022-29834-z |
| spellingShingle | Jelle van den Ameele Robert Krautz Seth W. Cheetham Alex P. A. Donovan Oriol Llorà-Batlle Rebecca Yakob Andrea H. Brand Reduced chromatin accessibility correlates with resistance to Notch activation Nature Communications |
| title | Reduced chromatin accessibility correlates with resistance to Notch activation |
| title_full | Reduced chromatin accessibility correlates with resistance to Notch activation |
| title_fullStr | Reduced chromatin accessibility correlates with resistance to Notch activation |
| title_full_unstemmed | Reduced chromatin accessibility correlates with resistance to Notch activation |
| title_short | Reduced chromatin accessibility correlates with resistance to Notch activation |
| title_sort | reduced chromatin accessibility correlates with resistance to notch activation |
| url | https://doi.org/10.1038/s41467-022-29834-z |
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