Diagnostic applications of the "pattern" electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in Parkinson’s disease
Background/Aim. In spite of continuous research efforts, specific laboratory, neuropsychological or neurophysiological tests for diagnosing Parkinson’s disease (PD) have not been established. The aim of the study was to determine the nature and extent of visual pathway disorders on “pattern” electro...
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| Format: | Article |
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Military Health Department, Ministry of Defance, Serbia
2022-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502000104S.pdf |
| _version_ | 1811312360542961664 |
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| author | Stamenović Jelena Živadinović Biljana Đurić Vanja Ljubisavljević Srđan |
| author_facet | Stamenović Jelena Živadinović Biljana Đurić Vanja Ljubisavljević Srđan |
| author_sort | Stamenović Jelena |
| collection | DOAJ |
| description | Background/Aim. In spite of continuous research efforts, specific laboratory, neuropsychological or neurophysiological tests for diagnosing Parkinson’s disease (PD) have not been established. The aim of the study was to determine the nature and extent of visual pathway disorders on “pattern” electroretinography (PERG) and visual evoked potentials (VEPs) in certain stages of PD. Methods. The study was carried out in a group of 60 persons of both sexes who were suffering from idiopathic PD at the I–IV stage of the disease according to the Hoehn and Yahr scale, and 30 healthy persons in the control group. The battery of noninvasive neurophysiological tests was used to estimate the functional status of the visual pathway − PERG and VEPs. Results. In the early phase of PD, there was a linear increase in the latency of the wave N50 of the PERG and the wave P100 of the VEPs, with a significant extension of the latency of the N50 and P100 waves in subsequent stages of PD. Diagnostic application of the PERG and VEPs enabled the confirmation of a disorder in the visual pathway function in PD. Conclusion. Applied neurophysiological techniques may record early changes in the function of retinal structures and the optic nerve in PD, which might be significant from both the diagnostic and therapeutic aspects. |
| first_indexed | 2024-04-13T10:34:56Z |
| format | Article |
| id | doaj.art-93e0bc66a57e429c9ece2cb8a40179ad |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-04-13T10:34:56Z |
| publishDate | 2022-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-93e0bc66a57e429c9ece2cb8a40179ad2022-12-22T02:50:04ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202022-01-0179431131710.2298/VSP200126104S0042-84502000104SDiagnostic applications of the "pattern" electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in Parkinson’s diseaseStamenović Jelena0Živadinović Biljana1https://orcid.org/0000-0002-2678-454XĐurić Vanja2Ljubisavljević Srđan3https://orcid.org/0000-0002-7028-522XUniversity of Niš, Faculty of Medicine, Niš, Serbia + University Clinical Center of Niš, Clinic for Neurology, Niš, Serbia University of Niš, Faculty of Medicine, Niš, Serbia + University Clinical Center of Niš, Clinic for Neurology, Niš, Serbia Polyclinic “Neuromedic“, Niš, SerbiaUniversity of Niš, Faculty of Medicine, Niš, Serbia + University Clinical Center of Niš, Clinic for Neurology, Niš, Serbia Background/Aim. In spite of continuous research efforts, specific laboratory, neuropsychological or neurophysiological tests for diagnosing Parkinson’s disease (PD) have not been established. The aim of the study was to determine the nature and extent of visual pathway disorders on “pattern” electroretinography (PERG) and visual evoked potentials (VEPs) in certain stages of PD. Methods. The study was carried out in a group of 60 persons of both sexes who were suffering from idiopathic PD at the I–IV stage of the disease according to the Hoehn and Yahr scale, and 30 healthy persons in the control group. The battery of noninvasive neurophysiological tests was used to estimate the functional status of the visual pathway − PERG and VEPs. Results. In the early phase of PD, there was a linear increase in the latency of the wave N50 of the PERG and the wave P100 of the VEPs, with a significant extension of the latency of the N50 and P100 waves in subsequent stages of PD. Diagnostic application of the PERG and VEPs enabled the confirmation of a disorder in the visual pathway function in PD. Conclusion. Applied neurophysiological techniques may record early changes in the function of retinal structures and the optic nerve in PD, which might be significant from both the diagnostic and therapeutic aspects.http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502000104S.pdfdiagnosiselectroretinographyevoked potentials, visualparkinson’s disease |
| spellingShingle | Stamenović Jelena Živadinović Biljana Đurić Vanja Ljubisavljević Srđan Diagnostic applications of the "pattern" electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in Parkinson’s disease Vojnosanitetski Pregled diagnosis electroretinography evoked potentials, visual parkinson’s disease |
| title | Diagnostic applications of the "pattern" electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in Parkinson’s disease |
| title_full | Diagnostic applications of the "pattern" electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in Parkinson’s disease |
| title_fullStr | Diagnostic applications of the "pattern" electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in Parkinson’s disease |
| title_full_unstemmed | Diagnostic applications of the "pattern" electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in Parkinson’s disease |
| title_short | Diagnostic applications of the "pattern" electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in Parkinson’s disease |
| title_sort | diagnostic applications of the pattern electroretinography and visual evoked potentials in the evaluation of disorders of visual pathway function in parkinson s disease |
| topic | diagnosis electroretinography evoked potentials, visual parkinson’s disease |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502000104S.pdf |
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