JmjC histone demethylases act as chromatin oxygen sensors
Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1608501 |
| _version_ | 1827809354320969728 |
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| author | Michael Batie Sonia Rocha |
| author_facet | Michael Batie Sonia Rocha |
| author_sort | Michael Batie |
| collection | DOAJ |
| description | Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia. |
| first_indexed | 2024-03-11T22:40:57Z |
| format | Article |
| id | doaj.art-93e1ea1748844913a3ee597aaae59a22 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:57Z |
| publishDate | 2019-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-93e1ea1748844913a3ee597aaae59a222023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-07-016410.1080/23723556.2019.16085011608501JmjC histone demethylases act as chromatin oxygen sensorsMichael Batie0Sonia Rocha1Institute of Integrative Biology, University of LiverpoolInstitute of Integrative Biology, University of LiverpoolOxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia.http://dx.doi.org/10.1080/23723556.2019.1608501hypoxiajmjc-histone demethylaseschromatinhif. transcription |
| spellingShingle | Michael Batie Sonia Rocha JmjC histone demethylases act as chromatin oxygen sensors Molecular & Cellular Oncology hypoxia jmjc-histone demethylases chromatin hif. transcription |
| title | JmjC histone demethylases act as chromatin oxygen sensors |
| title_full | JmjC histone demethylases act as chromatin oxygen sensors |
| title_fullStr | JmjC histone demethylases act as chromatin oxygen sensors |
| title_full_unstemmed | JmjC histone demethylases act as chromatin oxygen sensors |
| title_short | JmjC histone demethylases act as chromatin oxygen sensors |
| title_sort | jmjc histone demethylases act as chromatin oxygen sensors |
| topic | hypoxia jmjc-histone demethylases chromatin hif. transcription |
| url | http://dx.doi.org/10.1080/23723556.2019.1608501 |
| work_keys_str_mv | AT michaelbatie jmjchistonedemethylasesactaschromatinoxygensensors AT soniarocha jmjchistonedemethylasesactaschromatinoxygensensors |