Impact of Anemia on Chemotherapy Efficacy and Prognosis in Patients with Advanced Non-small Cell Lung Cancer
Background and objective Cancer-related anemia is the common complication of non-small cell lung cancer (NSCLC), which affects the quality of life (QOL), chemotherapy efficacy and prognosis in patients with NSCLC. In this study, we statistically analysed the incidence of anemia in NSCLC patients bef...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2010-10-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.10.07&path[]=2097 |
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| author | Chong'an XU Yan GAO Lin LI Lili XING Shu LIU |
| author_facet | Chong'an XU Yan GAO Lin LI Lili XING Shu LIU |
| author_sort | Chong'an XU |
| collection | DOAJ |
| description | Background and objective Cancer-related anemia is the common complication of non-small cell lung cancer (NSCLC), which affects the quality of life (QOL), chemotherapy efficacy and prognosis in patients with NSCLC. In this study, we statistically analysed the incidence of anemia in NSCLC patients before and after chemotherapy and related risk factors, and investigated the impact of anemia on QOL, chemotherapy efficacy and prognosis in patients with NSCLC. Methods Clinical data of 140 patients with NSCLC from January 2007 to December 2008 were collected and retrospectively analysed for the changes in hemoglobin levels before and after chemotherapy, the risk factors of anemia, and the relationship with chemotherapy efficacy and prognosis. Application of QOL scale (EORTCQLQ-C30, Chinese version) to evaluate the impact of anemia on QOL in patients with advanced NSCLC. Results Total 140 cases of NSCLC patients, the incidence of anemia after two cycles of chemotherapy was significantly higher than that before chemotherapy (71.4% vs 47.1%, P < 0.001), and the severity of anemia increased simultaneously with the cycles of chemotherapy. According to univariete and multivariate Logstic regression analysis, age, clinical stage, PS score and albumin levels were closely related to pre-treatment cancerrelated anemia. However, multivariate Logistic regression analysis confirmed that only albumin levels was the risk factors of anemia. QOL scores on physical function, symptoms and overall quality of life were significantly different in anemia and nonanemic patients (P < 0.05). Anemia occurred before and after chemotherapy were significantly lower chemotherapy efficacy in patients with advanced NSCLC. Cancer-related anemia obviously impacted on the prognosis of patients, the median survival of cancer-related anemia patients was significantly shorter than those without anemia (7 months vs 13 months, P < 0.001), and the median survival of cancer-related anemia patients before chemotherapy was significantly longer than those with anemia (7 months vs 11 months, P < 0.001). Cox multivariate regression analysis confirmed that anemia, clinical stage, PS score, albumin level were the independent prognostic factors in advanced NSCLC. Conclusion NSCLC patients had a higher incidence of anemia, especially the incidence of chemotherapy-related anemia, age, clinical stage, PS score, albumin levels were the risk factors of pre-treatment cancer-related anemia. NSCLC patients with anemia had lower QOL and chemotherapy efficacy, and shorter lifetime. Anemia was an independent prognostic factor in NSCLC patients. |
| first_indexed | 2024-04-12T23:50:21Z |
| format | Article |
| id | doaj.art-93e25da3059a4f8a982c139ebd80ac35 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-12T23:50:21Z |
| publishDate | 2010-10-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-93e25da3059a4f8a982c139ebd80ac352022-12-22T03:11:43ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872010-10-011310968974Impact of Anemia on Chemotherapy Efficacy and Prognosis in Patients with Advanced Non-small Cell Lung CancerChong'an XUYan GAOLin LILili XINGShu LIUBackground and objective Cancer-related anemia is the common complication of non-small cell lung cancer (NSCLC), which affects the quality of life (QOL), chemotherapy efficacy and prognosis in patients with NSCLC. In this study, we statistically analysed the incidence of anemia in NSCLC patients before and after chemotherapy and related risk factors, and investigated the impact of anemia on QOL, chemotherapy efficacy and prognosis in patients with NSCLC. Methods Clinical data of 140 patients with NSCLC from January 2007 to December 2008 were collected and retrospectively analysed for the changes in hemoglobin levels before and after chemotherapy, the risk factors of anemia, and the relationship with chemotherapy efficacy and prognosis. Application of QOL scale (EORTCQLQ-C30, Chinese version) to evaluate the impact of anemia on QOL in patients with advanced NSCLC. Results Total 140 cases of NSCLC patients, the incidence of anemia after two cycles of chemotherapy was significantly higher than that before chemotherapy (71.4% vs 47.1%, P < 0.001), and the severity of anemia increased simultaneously with the cycles of chemotherapy. According to univariete and multivariate Logstic regression analysis, age, clinical stage, PS score and albumin levels were closely related to pre-treatment cancerrelated anemia. However, multivariate Logistic regression analysis confirmed that only albumin levels was the risk factors of anemia. QOL scores on physical function, symptoms and overall quality of life were significantly different in anemia and nonanemic patients (P < 0.05). Anemia occurred before and after chemotherapy were significantly lower chemotherapy efficacy in patients with advanced NSCLC. Cancer-related anemia obviously impacted on the prognosis of patients, the median survival of cancer-related anemia patients was significantly shorter than those without anemia (7 months vs 13 months, P < 0.001), and the median survival of cancer-related anemia patients before chemotherapy was significantly longer than those with anemia (7 months vs 11 months, P < 0.001). Cox multivariate regression analysis confirmed that anemia, clinical stage, PS score, albumin level were the independent prognostic factors in advanced NSCLC. Conclusion NSCLC patients had a higher incidence of anemia, especially the incidence of chemotherapy-related anemia, age, clinical stage, PS score, albumin levels were the risk factors of pre-treatment cancer-related anemia. NSCLC patients with anemia had lower QOL and chemotherapy efficacy, and shorter lifetime. Anemia was an independent prognostic factor in NSCLC patients.http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.10.07&path[]=2097Lung neoplasmsCancer-related anemiaChemotherapy efficacyPrognosisQuality of life |
| spellingShingle | Chong'an XU Yan GAO Lin LI Lili XING Shu LIU Impact of Anemia on Chemotherapy Efficacy and Prognosis in Patients with Advanced Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms Cancer-related anemia Chemotherapy efficacy Prognosis Quality of life |
| title | Impact of Anemia on Chemotherapy Efficacy and Prognosis in Patients with Advanced Non-small Cell Lung Cancer |
| title_full | Impact of Anemia on Chemotherapy Efficacy and Prognosis in Patients with Advanced Non-small Cell Lung Cancer |
| title_fullStr | Impact of Anemia on Chemotherapy Efficacy and Prognosis in Patients with Advanced Non-small Cell Lung Cancer |
| title_full_unstemmed | Impact of Anemia on Chemotherapy Efficacy and Prognosis in Patients with Advanced Non-small Cell Lung Cancer |
| title_short | Impact of Anemia on Chemotherapy Efficacy and Prognosis in Patients with Advanced Non-small Cell Lung Cancer |
| title_sort | impact of anemia on chemotherapy efficacy and prognosis in patients with advanced non small cell lung cancer |
| topic | Lung neoplasms Cancer-related anemia Chemotherapy efficacy Prognosis Quality of life |
| url | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.10.07&path[]=2097 |
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