Assessment of non-motor symptoms of Parkinson's disease and their impact on the quality of life: An observatiobnal study
Background: During the past decade the view of Parkinson's disease (PD) as a motor disorder has changed significantly and currently it is recognized as a multisystem disorder with diverse non-motor symptoms (NMS). Aims: The present study aimed to evaluate and characterize the NMS and study thei...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=5;spage=909;epage=915;aulast=Kumar |
| _version_ | 1811308580383490048 |
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| author | Anand Kumar Sooraj Patil Varun K Singh Abhishek Pathak Rameshwar Nath Chaurasia Vijaya N Mishra Deepika Joshi |
| author_facet | Anand Kumar Sooraj Patil Varun K Singh Abhishek Pathak Rameshwar Nath Chaurasia Vijaya N Mishra Deepika Joshi |
| author_sort | Anand Kumar |
| collection | DOAJ |
| description | Background: During the past decade the view of Parkinson's disease (PD) as a motor disorder has changed significantly and currently it is recognized as a multisystem disorder with diverse non-motor symptoms (NMS). Aims: The present study aimed to evaluate and characterize the NMS and study their impact on quality of life (QoL) in a PD patient cohort. Material and Methods: This was a cross-sectional study where 92 PD patients fulfilling the UK Parkinson's disease society brain bank criteria were enrolled from a movement disorder clinic. All patients were evaluated using unified Parkinson's disease rating scale, non-motor symptoms scale (NMSS) for the non-motor symptoms, and Parkinson's disease questionnaire-39 (PDQ-39) for the QoL. The impact of NMS on QoL was assessed statistically. Results: A total of 92 patients were enrolled with a mean age of 55.40 ± 7.37 years, mean age of onset of disease 51.62 ± 6.38 years, and mean disease duration of 3.78 ± 1.54 years. Type of disease was akinetic rigid variant in 29.3% (n = 27), tremor predominant type in 36.9%(n = 34), and mixed type in 33.6% (n = 31). Mean Hoehn and Yahr stage was 2.12 ± 0.54. In the NMSS, most common symptom was sleep and fatigue (83%), followed by urinary tract symptoms (63%), mood and cognition (51%), cardiovascular symptoms and falls (43%), gastrointestinal tract symptoms (38%), and sexual function (33%). Univariate analyses showed that all NMS domains had a significant correlation with PDQ-39 with P < 001. Conclusion: Our study shows that NMS in PDare fairly common and significantly impact the QoL. |
| first_indexed | 2024-04-13T09:25:38Z |
| format | Article |
| id | doaj.art-93e313f7aab54b5f80d171ab0897dfad |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-04-13T09:25:38Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-93e313f7aab54b5f80d171ab0897dfad2022-12-22T02:52:27ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492022-01-0125590991510.4103/aian.aian_647_21Assessment of non-motor symptoms of Parkinson's disease and their impact on the quality of life: An observatiobnal studyAnand KumarSooraj PatilVarun K SinghAbhishek PathakRameshwar Nath ChaurasiaVijaya N MishraDeepika JoshiBackground: During the past decade the view of Parkinson's disease (PD) as a motor disorder has changed significantly and currently it is recognized as a multisystem disorder with diverse non-motor symptoms (NMS). Aims: The present study aimed to evaluate and characterize the NMS and study their impact on quality of life (QoL) in a PD patient cohort. Material and Methods: This was a cross-sectional study where 92 PD patients fulfilling the UK Parkinson's disease society brain bank criteria were enrolled from a movement disorder clinic. All patients were evaluated using unified Parkinson's disease rating scale, non-motor symptoms scale (NMSS) for the non-motor symptoms, and Parkinson's disease questionnaire-39 (PDQ-39) for the QoL. The impact of NMS on QoL was assessed statistically. Results: A total of 92 patients were enrolled with a mean age of 55.40 ± 7.37 years, mean age of onset of disease 51.62 ± 6.38 years, and mean disease duration of 3.78 ± 1.54 years. Type of disease was akinetic rigid variant in 29.3% (n = 27), tremor predominant type in 36.9%(n = 34), and mixed type in 33.6% (n = 31). Mean Hoehn and Yahr stage was 2.12 ± 0.54. In the NMSS, most common symptom was sleep and fatigue (83%), followed by urinary tract symptoms (63%), mood and cognition (51%), cardiovascular symptoms and falls (43%), gastrointestinal tract symptoms (38%), and sexual function (33%). Univariate analyses showed that all NMS domains had a significant correlation with PDQ-39 with P < 001. Conclusion: Our study shows that NMS in PDare fairly common and significantly impact the QoL.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=5;spage=909;epage=915;aulast=Kumarnmssnon-motor symptomspdq-39parkinson's diseaseupdrs |
| spellingShingle | Anand Kumar Sooraj Patil Varun K Singh Abhishek Pathak Rameshwar Nath Chaurasia Vijaya N Mishra Deepika Joshi Assessment of non-motor symptoms of Parkinson's disease and their impact on the quality of life: An observatiobnal study Annals of Indian Academy of Neurology nmss non-motor symptoms pdq-39 parkinson's disease updrs |
| title | Assessment of non-motor symptoms of Parkinson's disease and their impact on the quality of life: An observatiobnal study |
| title_full | Assessment of non-motor symptoms of Parkinson's disease and their impact on the quality of life: An observatiobnal study |
| title_fullStr | Assessment of non-motor symptoms of Parkinson's disease and their impact on the quality of life: An observatiobnal study |
| title_full_unstemmed | Assessment of non-motor symptoms of Parkinson's disease and their impact on the quality of life: An observatiobnal study |
| title_short | Assessment of non-motor symptoms of Parkinson's disease and their impact on the quality of life: An observatiobnal study |
| title_sort | assessment of non motor symptoms of parkinson s disease and their impact on the quality of life an observatiobnal study |
| topic | nmss non-motor symptoms pdq-39 parkinson's disease updrs |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=5;spage=909;epage=915;aulast=Kumar |
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