Severe COVID-19 Infection While on Long Standing Therapy with Hydroxychloroquine
A BSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic has placed a large demand on healthcare resources worldwide. Hydroxychloroquine is reported as an agent with potential benefit in prophylaxis and treatment and is being used for both. The authors hereby present the case of 63-year-old male...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2020-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/13775/44656_F(KM)_CE[Ra1]_KM_PF1(AKA_SL)_PFA(SHU)_PB(AKA_SHU)_PN(SL).pdf |
| _version_ | 1819071427073015808 |
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| author | Kartik Ramakrishna Gaston Habib Japjot Chahal Dragos Manta Pratishtha Gupta |
| author_facet | Kartik Ramakrishna Gaston Habib Japjot Chahal Dragos Manta Pratishtha Gupta |
| author_sort | Kartik Ramakrishna |
| collection | DOAJ |
| description | A
BSTRACT
The Coronavirus Disease 2019 (COVID-19) pandemic has placed a large demand on healthcare resources worldwide. Hydroxychloroquine is reported as an agent with potential benefit in prophylaxis and treatment and is being used for both. The authors hereby present the case of 63-year-old male patient with myasthenia gravis and 22-year-old female patient with mixed connective tissue disease, both on chronic therapy with hydroxychloroquine, who were admitted to intensive care with severe Acute Respiratory Distress Syndrome (ARDS) and COVID-19 infection. The patients had typical symptoms of fever, cough and dyspnea with lymphopenia on blood investigations. They were intubated and mechanically ventilated, requiring paralytics and proning, with subsequent dramatic improvement in oxygenation noted. This is the first report to describe the development of SARS-CoV-2 infection in patients already on hydroxychloroquine and demonstrates the need for robust clinical studies before we can recommend its use for routine prophylaxis in healthcare workers or exposed patient contacts. |
| first_indexed | 2024-12-21T17:21:39Z |
| format | Article |
| id | doaj.art-93e54915c260470f9908bb3fcbb3fbdf |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T17:21:39Z |
| publishDate | 2020-06-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-93e54915c260470f9908bb3fcbb3fbdf2022-12-21T18:56:09ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-06-01146OD04OD0410.7860/JCDR/2020/44656.13775Severe COVID-19 Infection While on Long Standing Therapy with HydroxychloroquineKartik Ramakrishna0Gaston Habib1Japjot Chahal2Dragos Manta3Pratishtha Gupta4Assistant Professor, Department of Pulmonary and Critical Care Medicine, State University of New York, Syracuse, New York, USA.Resident, Department of Internal Medicine, State University of New York, Syracuse, New York, USA.Resident, Department of Internal Medicine, State University of New York, Syracuse, New York, USA.Assistant Professor, Department of Pulmonary and Critical Care Medicine, State University of New York, Syracuse, New York, USA.Assistant Professor, Department of Internal Medicine, State University of New York, Syracuse, New York, USA.A BSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic has placed a large demand on healthcare resources worldwide. Hydroxychloroquine is reported as an agent with potential benefit in prophylaxis and treatment and is being used for both. The authors hereby present the case of 63-year-old male patient with myasthenia gravis and 22-year-old female patient with mixed connective tissue disease, both on chronic therapy with hydroxychloroquine, who were admitted to intensive care with severe Acute Respiratory Distress Syndrome (ARDS) and COVID-19 infection. The patients had typical symptoms of fever, cough and dyspnea with lymphopenia on blood investigations. They were intubated and mechanically ventilated, requiring paralytics and proning, with subsequent dramatic improvement in oxygenation noted. This is the first report to describe the development of SARS-CoV-2 infection in patients already on hydroxychloroquine and demonstrates the need for robust clinical studies before we can recommend its use for routine prophylaxis in healthcare workers or exposed patient contacts.https://jcdr.net/articles/PDF/13775/44656_F(KM)_CE[Ra1]_KM_PF1(AKA_SL)_PFA(SHU)_PB(AKA_SHU)_PN(SL).pdfanti-malarial drugcoronavirus diseasecovidpandemicprophylaxis |
| spellingShingle | Kartik Ramakrishna Gaston Habib Japjot Chahal Dragos Manta Pratishtha Gupta Severe COVID-19 Infection While on Long Standing Therapy with Hydroxychloroquine Journal of Clinical and Diagnostic Research anti-malarial drug coronavirus disease covid pandemic prophylaxis |
| title | Severe COVID-19 Infection While on Long Standing Therapy with Hydroxychloroquine |
| title_full | Severe COVID-19 Infection While on Long Standing Therapy with Hydroxychloroquine |
| title_fullStr | Severe COVID-19 Infection While on Long Standing Therapy with Hydroxychloroquine |
| title_full_unstemmed | Severe COVID-19 Infection While on Long Standing Therapy with Hydroxychloroquine |
| title_short | Severe COVID-19 Infection While on Long Standing Therapy with Hydroxychloroquine |
| title_sort | severe covid 19 infection while on long standing therapy with hydroxychloroquine |
| topic | anti-malarial drug coronavirus disease covid pandemic prophylaxis |
| url | https://jcdr.net/articles/PDF/13775/44656_F(KM)_CE[Ra1]_KM_PF1(AKA_SL)_PFA(SHU)_PB(AKA_SHU)_PN(SL).pdf |
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