Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Huntington Disease (HD) is a progressive neurodegenerative disease caused by an elongated CAG repeat in the huntingtin (HTT) gene that encodes a polyglutamine tract in the HTT protein. Proteolysis of the mutant HTT protein (mHTT) has been detected in human and murine HD brains and is implicated in t...

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Bibliographic Details
Main Authors: Bibiana K.Y. Wong, Dagmar E. Ehrnhoefer, Rona K. Graham, Dale D.O. Martin, Safia Ladha, Valeria Uribe, Lisa M. Stanek, Sonia Franciosi, Xiaofan Qiu, Yu Deng, Vlad Kovalik, Weining Zhang, Mahmoud A. Pouladi, Lamya S. Shihabuddin, Michael R. Hayden
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Neurobiology of Disease
Subjects:
Caspase-6
YAC128
Huntington Disease
Autophagy
p62
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000029

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