Ratio of IL-8 in CSF Versus Serum Is Elevated in Patients with Unruptured Brain Aneurysm
Only scarce data pertaining to interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human aneurysm can be found in the current literature. Therefore, the aim of this study was the evaluation of cerebrospinal fluid (CSF) and serum IL-8 and MCP-1 concentration in unrupture...
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| author | Joanna Kamińska Tomasz Lyson Robert Chrzanowski Karol Sawicki Anna J. Milewska Marzena Tylicka Justyna Zińczuk Joanna Matowicka-Karna Violetta Dymicka-Piekarska Zenon Mariak Olga M. Koper-Lenkiewicz |
| author_facet | Joanna Kamińska Tomasz Lyson Robert Chrzanowski Karol Sawicki Anna J. Milewska Marzena Tylicka Justyna Zińczuk Joanna Matowicka-Karna Violetta Dymicka-Piekarska Zenon Mariak Olga M. Koper-Lenkiewicz |
| author_sort | Joanna Kamińska |
| collection | DOAJ |
| description | Only scarce data pertaining to interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human aneurysm can be found in the current literature. Therefore, the aim of this study was the evaluation of cerebrospinal fluid (CSF) and serum IL-8 and MCP-1 concentration in unruptured intracranial aneurysm (UIA) patients (<i>n</i> = 25) compared to the control group (<i>n</i> = 20). IL-8 and MCP-1 concentrations were measured with ELISA method. We demonstrated that CSF IL-8 concentration of UIA patients is significantly higher (<i>p</i> < 0.001) than that presented in the serum, which can indicate its local synthesis within central nervous system. CSF IL-8 concentration was also significantly related to aneurysm size, which may reflect the participation of IL-8 in the formation and development of brain aneurysms. IL-8 Quotient (CSF IL-8 divided by serum IL-8) in UIA patients was statistically higher compared to control individuals (<i>p</i> = 0.045). However, the diagnostic utility analysis did not equivocally indicate the diagnostic usefulness of the IL-8 Quotient evaluation in brain aneurysm patients. Nevertheless, this aspect requires further study. |
| first_indexed | 2024-03-10T19:20:03Z |
| format | Article |
| id | doaj.art-93e6ef6ec517417f93ddc5010f131e44 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:20:03Z |
| publishDate | 2020-06-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-93e6ef6ec517417f93ddc5010f131e442023-11-20T03:01:38ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0196176110.3390/jcm9061761Ratio of IL-8 in CSF Versus Serum Is Elevated in Patients with Unruptured Brain AneurysmJoanna Kamińska0Tomasz Lyson1Robert Chrzanowski2Karol Sawicki3Anna J. Milewska4Marzena Tylicka5Justyna Zińczuk6Joanna Matowicka-Karna7Violetta Dymicka-Piekarska8Zenon Mariak9Olga M. Koper-Lenkiewicz10Department of Clinical Laboratory Diagnostics, Medical University of Białystok, Waszyngtona 15A St., 15-269 Białystok, PolandDepartment of Neurosurgery, Clinical Hospital of the Medical University of Białystok, M. Skłodowskiej-Curie 24A St., 15-276 Białystok, PolandDepartment of Neurosurgery, Clinical Hospital of the Medical University of Białystok, M. Skłodowskiej-Curie 24A St., 15-276 Białystok, PolandDepartment of Neurosurgery, Clinical Hospital of the Medical University of Białystok, M. Skłodowskiej-Curie 24A St., 15-276 Białystok, PolandDepartment of Statistics and Medical Informatics, Medical University of Bialystok, ul. Szpitalna 37, 15-295 Białystok, PolandDepartment of Biophysics, Medical University of Białystok, Mickiewicza 2A St., 15-089 Białystok, PolandDepartment of Clinical Laboratory Diagnostics, Medical University of Białystok, Waszyngtona 15A St., 15-269 Białystok, PolandDepartment of Clinical Laboratory Diagnostics, Medical University of Białystok, Waszyngtona 15A St., 15-269 Białystok, PolandDepartment of Clinical Laboratory Diagnostics, Medical University of Białystok, Waszyngtona 15A St., 15-269 Białystok, PolandDepartment of Neurosurgery, Clinical Hospital of the Medical University of Białystok, M. Skłodowskiej-Curie 24A St., 15-276 Białystok, PolandDepartment of Clinical Laboratory Diagnostics, Medical University of Białystok, Waszyngtona 15A St., 15-269 Białystok, PolandOnly scarce data pertaining to interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human aneurysm can be found in the current literature. Therefore, the aim of this study was the evaluation of cerebrospinal fluid (CSF) and serum IL-8 and MCP-1 concentration in unruptured intracranial aneurysm (UIA) patients (<i>n</i> = 25) compared to the control group (<i>n</i> = 20). IL-8 and MCP-1 concentrations were measured with ELISA method. We demonstrated that CSF IL-8 concentration of UIA patients is significantly higher (<i>p</i> < 0.001) than that presented in the serum, which can indicate its local synthesis within central nervous system. CSF IL-8 concentration was also significantly related to aneurysm size, which may reflect the participation of IL-8 in the formation and development of brain aneurysms. IL-8 Quotient (CSF IL-8 divided by serum IL-8) in UIA patients was statistically higher compared to control individuals (<i>p</i> = 0.045). However, the diagnostic utility analysis did not equivocally indicate the diagnostic usefulness of the IL-8 Quotient evaluation in brain aneurysm patients. Nevertheless, this aspect requires further study.https://www.mdpi.com/2077-0383/9/6/1761cerebrospinal fluidIL8/CXCL8–interleukin 8/C-X-C motif chemokine ligand 8MCP-1/CCL2–monocyte chemoattractant protein-1/C-C motif ligand 2unruptured intracranial aneurysm (UIA) |
| spellingShingle | Joanna Kamińska Tomasz Lyson Robert Chrzanowski Karol Sawicki Anna J. Milewska Marzena Tylicka Justyna Zińczuk Joanna Matowicka-Karna Violetta Dymicka-Piekarska Zenon Mariak Olga M. Koper-Lenkiewicz Ratio of IL-8 in CSF Versus Serum Is Elevated in Patients with Unruptured Brain Aneurysm Journal of Clinical Medicine cerebrospinal fluid IL8/CXCL8–interleukin 8/C-X-C motif chemokine ligand 8 MCP-1/CCL2–monocyte chemoattractant protein-1/C-C motif ligand 2 unruptured intracranial aneurysm (UIA) |
| title | Ratio of IL-8 in CSF Versus Serum Is Elevated in Patients with Unruptured Brain Aneurysm |
| title_full | Ratio of IL-8 in CSF Versus Serum Is Elevated in Patients with Unruptured Brain Aneurysm |
| title_fullStr | Ratio of IL-8 in CSF Versus Serum Is Elevated in Patients with Unruptured Brain Aneurysm |
| title_full_unstemmed | Ratio of IL-8 in CSF Versus Serum Is Elevated in Patients with Unruptured Brain Aneurysm |
| title_short | Ratio of IL-8 in CSF Versus Serum Is Elevated in Patients with Unruptured Brain Aneurysm |
| title_sort | ratio of il 8 in csf versus serum is elevated in patients with unruptured brain aneurysm |
| topic | cerebrospinal fluid IL8/CXCL8–interleukin 8/C-X-C motif chemokine ligand 8 MCP-1/CCL2–monocyte chemoattractant protein-1/C-C motif ligand 2 unruptured intracranial aneurysm (UIA) |
| url | https://www.mdpi.com/2077-0383/9/6/1761 |
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