Cell-Free Mitochondrial DNA in Acute Brain Injury
Traumatic brain injury and aneurysmal subarachnoid haemorrhage are a major cause of morbidity and mortality worldwide. Treatment options remain limited and are hampered by our understanding of the cellular and molecular mechanisms, including the inflammatory response observed in the brain. Mitochond...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2022-09-01
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| Series: | Neurotrauma Reports |
| Subjects: | |
| Online Access: | https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0032 |
| _version_ | 1827374184332787712 |
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| author | Saeed Kayhanian Angelos Glynos Richard Mair Andras Lakatos Peter J.A. Hutchinson Adel E. Helmy Patrick F. Chinnery |
| author_facet | Saeed Kayhanian Angelos Glynos Richard Mair Andras Lakatos Peter J.A. Hutchinson Adel E. Helmy Patrick F. Chinnery |
| author_sort | Saeed Kayhanian |
| collection | DOAJ |
| description | Traumatic brain injury and aneurysmal subarachnoid haemorrhage are a major cause of morbidity and mortality worldwide. Treatment options remain limited and are hampered by our understanding of the cellular and molecular mechanisms, including the inflammatory response observed in the brain. Mitochondrial DNA (mtDNA) has been shown to activate an innate inflammatory response by acting as a damage-associated molecular pattern (DAMP). Here, we show raised circulating cell-free (ccf) mtDNA levels in both cerebrospinal fluid (CSF) and serum within 48?h of brain injury. CSF ccf-mtDNA levels correlated with clinical severity and the interleukin-6 cytokine response. These findings support the use of ccf-mtDNA as a biomarker after acute brain injury linked to the inflammatory disease mechanism. |
| first_indexed | 2024-03-08T11:29:11Z |
| format | Article |
| id | doaj.art-93e831e0f1d6449bba530441169b36da |
| institution | Directory Open Access Journal |
| issn | 2689-288X |
| language | English |
| last_indexed | 2024-03-08T11:29:11Z |
| publishDate | 2022-09-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj.art-93e831e0f1d6449bba530441169b36da2024-01-26T04:32:52ZengMary Ann LiebertNeurotrauma Reports2689-288X2022-09-013141542010.1089/NEUR.2022.0032Cell-Free Mitochondrial DNA in Acute Brain InjurySaeed KayhanianAngelos GlynosRichard MairAndras LakatosPeter J.A. HutchinsonAdel E. HelmyPatrick F. ChinneryTraumatic brain injury and aneurysmal subarachnoid haemorrhage are a major cause of morbidity and mortality worldwide. Treatment options remain limited and are hampered by our understanding of the cellular and molecular mechanisms, including the inflammatory response observed in the brain. Mitochondrial DNA (mtDNA) has been shown to activate an innate inflammatory response by acting as a damage-associated molecular pattern (DAMP). Here, we show raised circulating cell-free (ccf) mtDNA levels in both cerebrospinal fluid (CSF) and serum within 48?h of brain injury. CSF ccf-mtDNA levels correlated with clinical severity and the interleukin-6 cytokine response. These findings support the use of ccf-mtDNA as a biomarker after acute brain injury linked to the inflammatory disease mechanism.https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0032acute brain injurybrain inflammationDAMPmitochondrial DNAsubarachnoid hemorrhagetraumatic brain injury |
| spellingShingle | Saeed Kayhanian Angelos Glynos Richard Mair Andras Lakatos Peter J.A. Hutchinson Adel E. Helmy Patrick F. Chinnery Cell-Free Mitochondrial DNA in Acute Brain Injury Neurotrauma Reports acute brain injury brain inflammation DAMP mitochondrial DNA subarachnoid hemorrhage traumatic brain injury |
| title | Cell-Free Mitochondrial DNA in Acute Brain Injury |
| title_full | Cell-Free Mitochondrial DNA in Acute Brain Injury |
| title_fullStr | Cell-Free Mitochondrial DNA in Acute Brain Injury |
| title_full_unstemmed | Cell-Free Mitochondrial DNA in Acute Brain Injury |
| title_short | Cell-Free Mitochondrial DNA in Acute Brain Injury |
| title_sort | cell free mitochondrial dna in acute brain injury |
| topic | acute brain injury brain inflammation DAMP mitochondrial DNA subarachnoid hemorrhage traumatic brain injury |
| url | https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0032 |
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