The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies
This systematic review and meta-analysis aimed to assess the predictive value of diabetic retinopathy (DR) on further diabetic nephropathy (DN) risk in patients with type 2 diabetes (T2D) based on the prospective cohort studies. PubMed, Embase, and the Cochrane Library were systematically searched f...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2020.1866010 |
| _version_ | 1798024889580388352 |
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| author | Yu Li Xiaoxuan Su Qing Ye Xiaodan Guo Bo Xu Tianjun Guan Anqun Chen |
| author_facet | Yu Li Xiaoxuan Su Qing Ye Xiaodan Guo Bo Xu Tianjun Guan Anqun Chen |
| author_sort | Yu Li |
| collection | DOAJ |
| description | This systematic review and meta-analysis aimed to assess the predictive value of diabetic retinopathy (DR) on further diabetic nephropathy (DN) risk in patients with type 2 diabetes (T2D) based on the prospective cohort studies. PubMed, Embase, and the Cochrane Library were systematically searched for eligible prospective cohort studies through March 2020. The predictive value of DR was assessed using sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) through the bivariate generalized linear mixed model and the random-effects model. Ten prospective cohort studies recruited 635 patients with T2D. The pooled sensitivity and specificity of DR for predicted DN were noted to be 0.64 (95% CI, 0.54–0.73) and 0.77 (95% CI, 0.60–0.88), respectively. The pooled PLR and NLR of DR for predicted DN were 2.72 (95% CI, 1.42–5.19) and 0.47 (95% CI, 0.33–0.67), respectively. The summary DOR for the relationship between DR and subsequent DN for T2D patients was 5.53 (95% CI, 2.00–15.30), and the AUC of DR for predicted DN was 0.73 (95% CI, 0.69–0.77). This study found significant associations between DR and subsequent DN risk for patients with T2D. Moreover, the predictive value of DR on subsequent DN risk was relatively lower. |
| first_indexed | 2024-04-11T18:09:53Z |
| format | Article |
| id | doaj.art-93ea6a52d8ad47c2a48123f796ee1086 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-11T18:09:53Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-93ea6a52d8ad47c2a48123f796ee10862022-12-22T04:10:11ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492021-01-0143123124010.1080/0886022X.2020.18660101866010The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studiesYu Li0Xiaoxuan Su1Qing Ye2Xiaodan Guo3Bo Xu4Tianjun Guan5Anqun Chen6Division of Nephrology, Zhongshan Hospital, Xiamen UniversityDivision of Nephrology, Zhongshan Hospital, Xiamen UniversityDivision of Nephrology, Zhongshan Hospital, Xiamen UniversityDivision of Nephrology, Zhongshan Hospital, Xiamen UniversityDivision of Nephrology, Zhongshan Hospital, Xiamen UniversityDivision of Nephrology, Zhongshan Hospital, Xiamen UniversityDivision of Nephrology, Zhongshan Hospital, Xiamen UniversityThis systematic review and meta-analysis aimed to assess the predictive value of diabetic retinopathy (DR) on further diabetic nephropathy (DN) risk in patients with type 2 diabetes (T2D) based on the prospective cohort studies. PubMed, Embase, and the Cochrane Library were systematically searched for eligible prospective cohort studies through March 2020. The predictive value of DR was assessed using sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) through the bivariate generalized linear mixed model and the random-effects model. Ten prospective cohort studies recruited 635 patients with T2D. The pooled sensitivity and specificity of DR for predicted DN were noted to be 0.64 (95% CI, 0.54–0.73) and 0.77 (95% CI, 0.60–0.88), respectively. The pooled PLR and NLR of DR for predicted DN were 2.72 (95% CI, 1.42–5.19) and 0.47 (95% CI, 0.33–0.67), respectively. The summary DOR for the relationship between DR and subsequent DN for T2D patients was 5.53 (95% CI, 2.00–15.30), and the AUC of DR for predicted DN was 0.73 (95% CI, 0.69–0.77). This study found significant associations between DR and subsequent DN risk for patients with T2D. Moreover, the predictive value of DR on subsequent DN risk was relatively lower.http://dx.doi.org/10.1080/0886022X.2020.1866010diabetic retinopathydiabetic nephropathytype 2 diabetesmeta-analysis |
| spellingShingle | Yu Li Xiaoxuan Su Qing Ye Xiaodan Guo Bo Xu Tianjun Guan Anqun Chen The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies Renal Failure diabetic retinopathy diabetic nephropathy type 2 diabetes meta-analysis |
| title | The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies |
| title_full | The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies |
| title_fullStr | The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies |
| title_full_unstemmed | The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies |
| title_short | The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies |
| title_sort | predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes a systematic review and meta analysis of prospective studies |
| topic | diabetic retinopathy diabetic nephropathy type 2 diabetes meta-analysis |
| url | http://dx.doi.org/10.1080/0886022X.2020.1866010 |
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