Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: an important step forward from the chemotherapy era
Alexandra Traila,1,2,* Delia Dima,3 Patriciu Achimas-Cadariu,1,2,* Romeo Micu1,4 1School of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; 2Department of Surgical Oncology, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania; 3Department of Hematology, Ion Ch...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-06-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/fertility-preservation-in-hodgkins-lymphoma-patients-that-undergo-targ-peer-reviewed-article-CMAR |
| _version_ | 1828521307815280640 |
|---|---|
| author | Traila A Dima D Achimas-Cadariu P Micu R |
| author_facet | Traila A Dima D Achimas-Cadariu P Micu R |
| author_sort | Traila A |
| collection | DOAJ |
| description | Alexandra Traila,1,2,* Delia Dima,3 Patriciu Achimas-Cadariu,1,2,* Romeo Micu1,4 1School of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; 2Department of Surgical Oncology, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania; 3Department of Hematology, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania; 4Department of Human Assisted Reproduction of 1st Gynecology Clinic, Cluj Napoca, Romania *These authors contributed equally to this work Abstract: In total, 80%–90% of Hodgkin’s lymphoma (HL) patients are curable with combination chemoradiotherapy. Due to improvements in therapeutic strategies, 50% of all relapsed/refractory patients may undergo complete clinical responses and have long-term survival. Treatment options for HL are effective, but may have a negative impact on post-chemotherapy fertility. Thus, cryopreservation of semen prior to treatment is recommended for male patients. For female patients, assisted reproductive techniques (ART) consult and fertility preservation should be offered as a therapeutical option. In the last years, new targeted molecules have been available for HL treatment. These new drugs showed a high rate of overall responses in the setting of heavily pretreated patients, most of them in relapse after autologous stem cell transplantation, a group previously considered very poor risk. Up to 50% of patients have a complete response and an improved overall survival. Future studies will address the usefulness of novel molecules as a frontline therapy. Considering the high response and survival rates with monoclonal antibody-based therapeutics, fertility has become a concerning issue for long-term HL survivors. As progress has been made regarding ART, with the rigorous steps planned for HL patients, more survivors will become parents. Keywords: Hodgkin’s lymphoma, infertility, pregnancy, fertility preservation |
| first_indexed | 2024-12-11T19:46:21Z |
| format | Article |
| id | doaj.art-93ec9201846a40e5be4fcf262be557ad |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-11T19:46:21Z |
| publishDate | 2018-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-93ec9201846a40e5be4fcf262be557ad2022-12-22T00:52:53ZengDove Medical PressCancer Management and Research1179-13222018-06-01Volume 101517152638789Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: an important step forward from the chemotherapy eraTraila ADima DAchimas-Cadariu PMicu RAlexandra Traila,1,2,* Delia Dima,3 Patriciu Achimas-Cadariu,1,2,* Romeo Micu1,4 1School of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; 2Department of Surgical Oncology, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania; 3Department of Hematology, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania; 4Department of Human Assisted Reproduction of 1st Gynecology Clinic, Cluj Napoca, Romania *These authors contributed equally to this work Abstract: In total, 80%–90% of Hodgkin’s lymphoma (HL) patients are curable with combination chemoradiotherapy. Due to improvements in therapeutic strategies, 50% of all relapsed/refractory patients may undergo complete clinical responses and have long-term survival. Treatment options for HL are effective, but may have a negative impact on post-chemotherapy fertility. Thus, cryopreservation of semen prior to treatment is recommended for male patients. For female patients, assisted reproductive techniques (ART) consult and fertility preservation should be offered as a therapeutical option. In the last years, new targeted molecules have been available for HL treatment. These new drugs showed a high rate of overall responses in the setting of heavily pretreated patients, most of them in relapse after autologous stem cell transplantation, a group previously considered very poor risk. Up to 50% of patients have a complete response and an improved overall survival. Future studies will address the usefulness of novel molecules as a frontline therapy. Considering the high response and survival rates with monoclonal antibody-based therapeutics, fertility has become a concerning issue for long-term HL survivors. As progress has been made regarding ART, with the rigorous steps planned for HL patients, more survivors will become parents. Keywords: Hodgkin’s lymphoma, infertility, pregnancy, fertility preservationhttps://www.dovepress.com/fertility-preservation-in-hodgkins-lymphoma-patients-that-undergo-targ-peer-reviewed-article-CMARHodgkin's lymphomainfertilitypregnancyfertility preservation |
| spellingShingle | Traila A Dima D Achimas-Cadariu P Micu R Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: an important step forward from the chemotherapy era Cancer Management and Research Hodgkin's lymphoma infertility pregnancy fertility preservation |
| title | Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: an important step forward from the chemotherapy era |
| title_full | Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: an important step forward from the chemotherapy era |
| title_fullStr | Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: an important step forward from the chemotherapy era |
| title_full_unstemmed | Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: an important step forward from the chemotherapy era |
| title_short | Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: an important step forward from the chemotherapy era |
| title_sort | fertility preservation in hodgkin rsquo s lymphoma patients that undergo targeted molecular therapies an important step forward from the chemotherapy era |
| topic | Hodgkin's lymphoma infertility pregnancy fertility preservation |
| url | https://www.dovepress.com/fertility-preservation-in-hodgkins-lymphoma-patients-that-undergo-targ-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT trailaa fertilitypreservationinhodgkinrsquoslymphomapatientsthatundergotargetedmoleculartherapiesanimportantstepforwardfromthechemotherapyera AT dimad fertilitypreservationinhodgkinrsquoslymphomapatientsthatundergotargetedmoleculartherapiesanimportantstepforwardfromthechemotherapyera AT achimascadariup fertilitypreservationinhodgkinrsquoslymphomapatientsthatundergotargetedmoleculartherapiesanimportantstepforwardfromthechemotherapyera AT micur fertilitypreservationinhodgkinrsquoslymphomapatientsthatundergotargetedmoleculartherapiesanimportantstepforwardfromthechemotherapyera |