Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient
Aseptic abscess syndrome (AAS) is a rare, potentially life-threatening disorder, with numerous features of neutrophilic dermatoses. The main symptoms include aseptic abscess-like collections in internal organs (spleen, liver, lungs), lack of microbes (bacteria, viruses, or parasites) after an exhaus...
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MDPI AG
2022-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/10/1354 |
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| author | Agnieszka Owczarczyk-Saczonek Marta Kasprowicz-Furmańczyk Jakub Kuna Paulina Klimek Magdalena Krajewska-Włodarczyk |
| author_facet | Agnieszka Owczarczyk-Saczonek Marta Kasprowicz-Furmańczyk Jakub Kuna Paulina Klimek Magdalena Krajewska-Włodarczyk |
| author_sort | Agnieszka Owczarczyk-Saczonek |
| collection | DOAJ |
| description | Aseptic abscess syndrome (AAS) is a rare, potentially life-threatening disorder, with numerous features of neutrophilic dermatoses. The main symptoms include aseptic abscess-like collections in internal organs (spleen, liver, lungs), lack of microbes (bacteria, viruses, or parasites) after an exhaustive search, ineffectiveness of antibiotics, and high sensitivity to corticosteroid therapy. AAS is characterized by the development of deep, inflammatory abscesses and systemic symptoms (weight loss, abdominal pain, fever, and leukocytosis). They may be associated with inflammatory bowel disease (IBD) and autoimmune diseases. The patient in this study is a 67-year-old man, suffering from rheumatoid arthritis (RA), with numerous purulent abscesses in the mediastinum, within the subcutaneous tissue above the extension surfaces of the joints, and on the dorsum of the hands. The lesions are accompanied by bone destruction. The patient was treated with prednisone 40 mg and adalimumab, which resulted in a quick reduction of inflammatory markers and clinical improvement, as well as the healing and absorption of abscesses. Despite COVID-19 infection, treatment with remdesivir, prednisone, and adalimumab was continued, with the complete resolution of the lesions. AAS is difficult to recognize, so practitioners have to be aware of this condition, especially in patients with RA. |
| first_indexed | 2024-03-09T19:51:22Z |
| format | Article |
| id | doaj.art-93ed6166954a41ceb6b1b8c88d38f571 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T19:51:22Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-93ed6166954a41ceb6b1b8c88d38f5712023-11-24T01:09:41ZengMDPI AGMedicina1010-660X1648-91442022-09-015810135410.3390/medicina58101354Aseptic Abscess Syndrome in Rheumatoid Arthritis PatientAgnieszka Owczarczyk-Saczonek0Marta Kasprowicz-Furmańczyk1Jakub Kuna2Paulina Klimek3Magdalena Krajewska-Włodarczyk4Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, The University of Warmia and Mazury, Al. Wojska Polskiego 30, 10-229 Olsztyn, PolandDepartment of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, The University of Warmia and Mazury, Al. Wojska Polskiego 30, 10-229 Olsztyn, PolandDepartment of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, PolandDepartment of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, The University of Warmia and Mazury, Al. Wojska Polskiego 30, 10-229 Olsztyn, PolandDepartment of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, PolandAseptic abscess syndrome (AAS) is a rare, potentially life-threatening disorder, with numerous features of neutrophilic dermatoses. The main symptoms include aseptic abscess-like collections in internal organs (spleen, liver, lungs), lack of microbes (bacteria, viruses, or parasites) after an exhaustive search, ineffectiveness of antibiotics, and high sensitivity to corticosteroid therapy. AAS is characterized by the development of deep, inflammatory abscesses and systemic symptoms (weight loss, abdominal pain, fever, and leukocytosis). They may be associated with inflammatory bowel disease (IBD) and autoimmune diseases. The patient in this study is a 67-year-old man, suffering from rheumatoid arthritis (RA), with numerous purulent abscesses in the mediastinum, within the subcutaneous tissue above the extension surfaces of the joints, and on the dorsum of the hands. The lesions are accompanied by bone destruction. The patient was treated with prednisone 40 mg and adalimumab, which resulted in a quick reduction of inflammatory markers and clinical improvement, as well as the healing and absorption of abscesses. Despite COVID-19 infection, treatment with remdesivir, prednisone, and adalimumab was continued, with the complete resolution of the lesions. AAS is difficult to recognize, so practitioners have to be aware of this condition, especially in patients with RA.https://www.mdpi.com/1648-9144/58/10/1354aseptic abscess syndromerheumatoid arthritisadalimumab |
| spellingShingle | Agnieszka Owczarczyk-Saczonek Marta Kasprowicz-Furmańczyk Jakub Kuna Paulina Klimek Magdalena Krajewska-Włodarczyk Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient Medicina aseptic abscess syndrome rheumatoid arthritis adalimumab |
| title | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
| title_full | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
| title_fullStr | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
| title_full_unstemmed | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
| title_short | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
| title_sort | aseptic abscess syndrome in rheumatoid arthritis patient |
| topic | aseptic abscess syndrome rheumatoid arthritis adalimumab |
| url | https://www.mdpi.com/1648-9144/58/10/1354 |
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