Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke
Tianyi Rong,* Min He,* Yun Hua, Deyan Chen, Miao Chen Department of Neurology, Shidong Hospital of Yangpu District, Shanghai 200438, People’s Republic of China*These authors contributed equally to this workCorrespondence: Miao ChenDepartment of Neurology, Shidong Hospital of Yangpu Distric...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-12-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/associations-of-interleukin-10-matrix-metallopeptidase-9-and-legumain--peer-reviewed-article-IJGM |
| _version_ | 1818392186438287360 |
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| author | Rong T He M Hua Y Chen D Chen M |
| author_facet | Rong T He M Hua Y Chen D Chen M |
| author_sort | Rong T |
| collection | DOAJ |
| description | Tianyi Rong,* Min He,* Yun Hua, Deyan Chen, Miao Chen Department of Neurology, Shidong Hospital of Yangpu District, Shanghai 200438, People’s Republic of China*These authors contributed equally to this workCorrespondence: Miao ChenDepartment of Neurology, Shidong Hospital of Yangpu District, Shanghai 200438, People’s Republic of ChinaEmail marcy_cm@163.comBackground: Timely diagnosis and treatment are crucial to improve prognosis of ischemic stroke, making exploring factors associated with prognosis essential. Blood pressure variability (BPV) was reported to be associated with neurologic outcome, and basic researches on cardiovascular diseases found abnormal expression patterns of several factors including interleukin 10 (IL-10), matrix metallopeptidase 9 (MMP-9), and legumain which might be related to abnormal BPV but yet to prove in ischemic stroke. The study aimed to investigate whether IL-10, MMP-9, and legumain are associated with BPV and neurologic outcome of patients with ischemic stroke.Patients and Methods: Newly diagnosed ischemic stroke patients admitted to the department of neurology, Shidong Hospital of Yangpu District in Shanghai between July 2017 and January 2019 were enrolled. IL-10, MMP-9, and legumain were detected and BPV was assessed within 72 hours after admission. All the patients were followed for neurologic outcomes at discharge and 6 months after admission based on the Modified Rankin Scale (MRS). Correlations of IL-10, MMP-9, and legumain with BPV were examined by Spearman correlation coefficient, and their associations with neurologic outcomes were evaluated by multivariable linear regression.Results: A total of 349 patients with ischemic stroke were enrolled with an average age of 72.97± 11.47 years. Compared with non-progressive ischemic stroke, patients with progressive ischemic stroke had significantly higher IL-10, MMP-9, and legumain on admission. MMP-9 was found to be positively correlated with BPV while no significant correlation was found for IL-10 and legumain with BPV. MMP-9 was associated with progressive ischemic stroke [β=0.23 (95% CI 0.11– 0.35) per SD increase for MRS at discharge, and β=0.32 (95% CI 0.20– 0.43) per SD increase for MRS at 6 months after admission].Conclusion: Increased MMP-9 was associated with increased BPV and progressive ischemic stroke for patients with ischemic stroke, which might partially explain the effect of BPV on neurologic outcomes.Keywords: interleukin 10, matrix metallopeptidase 9, legumain, blood pressure variability, ischemic stroke |
| first_indexed | 2024-12-14T05:25:25Z |
| format | Article |
| id | doaj.art-93eef57162c84858a049385b9bfda18c |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-14T05:25:25Z |
| publishDate | 2020-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-93eef57162c84858a049385b9bfda18c2022-12-21T23:15:33ZengDove Medical PressInternational Journal of General Medicine1178-70742020-12-01Volume 131595160260393Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic StrokeRong THe MHua YChen DChen MTianyi Rong,* Min He,* Yun Hua, Deyan Chen, Miao Chen Department of Neurology, Shidong Hospital of Yangpu District, Shanghai 200438, People’s Republic of China*These authors contributed equally to this workCorrespondence: Miao ChenDepartment of Neurology, Shidong Hospital of Yangpu District, Shanghai 200438, People’s Republic of ChinaEmail marcy_cm@163.comBackground: Timely diagnosis and treatment are crucial to improve prognosis of ischemic stroke, making exploring factors associated with prognosis essential. Blood pressure variability (BPV) was reported to be associated with neurologic outcome, and basic researches on cardiovascular diseases found abnormal expression patterns of several factors including interleukin 10 (IL-10), matrix metallopeptidase 9 (MMP-9), and legumain which might be related to abnormal BPV but yet to prove in ischemic stroke. The study aimed to investigate whether IL-10, MMP-9, and legumain are associated with BPV and neurologic outcome of patients with ischemic stroke.Patients and Methods: Newly diagnosed ischemic stroke patients admitted to the department of neurology, Shidong Hospital of Yangpu District in Shanghai between July 2017 and January 2019 were enrolled. IL-10, MMP-9, and legumain were detected and BPV was assessed within 72 hours after admission. All the patients were followed for neurologic outcomes at discharge and 6 months after admission based on the Modified Rankin Scale (MRS). Correlations of IL-10, MMP-9, and legumain with BPV were examined by Spearman correlation coefficient, and their associations with neurologic outcomes were evaluated by multivariable linear regression.Results: A total of 349 patients with ischemic stroke were enrolled with an average age of 72.97± 11.47 years. Compared with non-progressive ischemic stroke, patients with progressive ischemic stroke had significantly higher IL-10, MMP-9, and legumain on admission. MMP-9 was found to be positively correlated with BPV while no significant correlation was found for IL-10 and legumain with BPV. MMP-9 was associated with progressive ischemic stroke [β=0.23 (95% CI 0.11– 0.35) per SD increase for MRS at discharge, and β=0.32 (95% CI 0.20– 0.43) per SD increase for MRS at 6 months after admission].Conclusion: Increased MMP-9 was associated with increased BPV and progressive ischemic stroke for patients with ischemic stroke, which might partially explain the effect of BPV on neurologic outcomes.Keywords: interleukin 10, matrix metallopeptidase 9, legumain, blood pressure variability, ischemic strokehttps://www.dovepress.com/associations-of-interleukin-10-matrix-metallopeptidase-9-and-legumain--peer-reviewed-article-IJGMinterleukin 10matrix metallopeptidase 9legumainblood pressure variabilityischemic stroke |
| spellingShingle | Rong T He M Hua Y Chen D Chen M Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke International Journal of General Medicine interleukin 10 matrix metallopeptidase 9 legumain blood pressure variability ischemic stroke |
| title | Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke |
| title_full | Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke |
| title_fullStr | Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke |
| title_full_unstemmed | Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke |
| title_short | Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke |
| title_sort | associations of interleukin 10 matrix metallopeptidase 9 and legumain with blood pressure variability and neurologic outcomes in patients with ischemic stroke |
| topic | interleukin 10 matrix metallopeptidase 9 legumain blood pressure variability ischemic stroke |
| url | https://www.dovepress.com/associations-of-interleukin-10-matrix-metallopeptidase-9-and-legumain--peer-reviewed-article-IJGM |
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