A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives
A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, f...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/16/9/7377/ |
| _version_ | 1811278192176005120 |
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| author | Jean Pierre Bazureau Laurent Meijer Olivier Lozach Ludovic Paquin Khadidja Bourahla François Carreaux |
| author_facet | Jean Pierre Bazureau Laurent Meijer Olivier Lozach Ludovic Paquin Khadidja Bourahla François Carreaux |
| author_sort | Jean Pierre Bazureau |
| collection | DOAJ |
| description | A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes. |
| first_indexed | 2024-04-13T00:31:21Z |
| format | Article |
| id | doaj.art-93f4622315984d209143c2af77e6ffbc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T00:31:21Z |
| publishDate | 2011-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-93f4622315984d209143c2af77e6ffbc2022-12-22T03:10:28ZengMDPI AGMolecules1420-30492011-08-011697377739010.3390/molecules16097377A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one DerivativesJean Pierre BazureauLaurent MeijerOlivier LozachLudovic PaquinKhadidja BourahlaFrançois CarreauxA practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.http://www.mdpi.com/1420-3049/16/9/7377/1,5-dihydro-4H-imidazol-4oneKnoevenagel condensationmicrowave irradiationS-alkylation |
| spellingShingle | Jean Pierre Bazureau Laurent Meijer Olivier Lozach Ludovic Paquin Khadidja Bourahla François Carreaux A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives Molecules 1,5-dihydro-4H-imidazol-4one Knoevenagel condensation microwave irradiation S-alkylation |
| title | A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives |
| title_full | A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives |
| title_fullStr | A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives |
| title_full_unstemmed | A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives |
| title_short | A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives |
| title_sort | practical approach to new 5z 2 alkylthio 5 arylmethylene 1 methyl 1 5 dihydro 4h imidazol 4 one derivatives |
| topic | 1,5-dihydro-4H-imidazol-4one Knoevenagel condensation microwave irradiation S-alkylation |
| url | http://www.mdpi.com/1420-3049/16/9/7377/ |
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