Clinical Perspectives of Single-Cell RNA Sequencing
The ability of single-cell genomics to resolve cellular heterogeneity is highly appreciated in cancer and is being exploited for precision medicine. In the recent decade, we have witnessed the incorporation of cancer genomics into the clinical decision-making process for molecular-targeted therapies...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/8/1161 |
| _version_ | 1797524589593493504 |
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| author | Nayoung Kim Hye Hyeon Eum Hae-Ock Lee |
| author_facet | Nayoung Kim Hye Hyeon Eum Hae-Ock Lee |
| author_sort | Nayoung Kim |
| collection | DOAJ |
| description | The ability of single-cell genomics to resolve cellular heterogeneity is highly appreciated in cancer and is being exploited for precision medicine. In the recent decade, we have witnessed the incorporation of cancer genomics into the clinical decision-making process for molecular-targeted therapies. Compared with conventional genomics, which primarily focuses on the specific and sensitive detection of the molecular targets, single-cell genomics addresses intratumoral heterogeneity and the microenvironmental components impacting the treatment response and resistance. As an exploratory tool, single-cell genomics provides an unprecedented opportunity to improve the diagnosis, monitoring, and treatment of cancer. The results obtained upon employing bulk cancer genomics indicate that single-cell genomics is at an early stage with respect to exploration of clinical relevance and requires further innovations to become a widely utilized technology in the clinic. |
| first_indexed | 2024-03-10T08:58:36Z |
| format | Article |
| id | doaj.art-93f4970c93b8485283044e591220727c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T08:58:36Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-93f4970c93b8485283044e591220727c2023-11-22T06:55:42ZengMDPI AGBiomolecules2218-273X2021-08-01118116110.3390/biom11081161Clinical Perspectives of Single-Cell RNA SequencingNayoung Kim0Hye Hyeon Eum1Hae-Ock Lee2Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaThe ability of single-cell genomics to resolve cellular heterogeneity is highly appreciated in cancer and is being exploited for precision medicine. In the recent decade, we have witnessed the incorporation of cancer genomics into the clinical decision-making process for molecular-targeted therapies. Compared with conventional genomics, which primarily focuses on the specific and sensitive detection of the molecular targets, single-cell genomics addresses intratumoral heterogeneity and the microenvironmental components impacting the treatment response and resistance. As an exploratory tool, single-cell genomics provides an unprecedented opportunity to improve the diagnosis, monitoring, and treatment of cancer. The results obtained upon employing bulk cancer genomics indicate that single-cell genomics is at an early stage with respect to exploration of clinical relevance and requires further innovations to become a widely utilized technology in the clinic.https://www.mdpi.com/2218-273X/11/8/1161single-cell genomicssingle-cell RNA sequencingtreatment responsepatient stratificationclinical decision |
| spellingShingle | Nayoung Kim Hye Hyeon Eum Hae-Ock Lee Clinical Perspectives of Single-Cell RNA Sequencing Biomolecules single-cell genomics single-cell RNA sequencing treatment response patient stratification clinical decision |
| title | Clinical Perspectives of Single-Cell RNA Sequencing |
| title_full | Clinical Perspectives of Single-Cell RNA Sequencing |
| title_fullStr | Clinical Perspectives of Single-Cell RNA Sequencing |
| title_full_unstemmed | Clinical Perspectives of Single-Cell RNA Sequencing |
| title_short | Clinical Perspectives of Single-Cell RNA Sequencing |
| title_sort | clinical perspectives of single cell rna sequencing |
| topic | single-cell genomics single-cell RNA sequencing treatment response patient stratification clinical decision |
| url | https://www.mdpi.com/2218-273X/11/8/1161 |
| work_keys_str_mv | AT nayoungkim clinicalperspectivesofsinglecellrnasequencing AT hyehyeoneum clinicalperspectivesofsinglecellrnasequencing AT haeocklee clinicalperspectivesofsinglecellrnasequencing |