Association between renal function and bone mineral density in patients with type 2 diabetes mellitus
Background: This study evaluated the association between renal function, assessed by serum creatinine and estimated glomerular filtration rate (eGFR) according to the Cockcroft–Gault (CG) and Modification of Diet in Renal Disease (MDRD) equations, and bone mineral density (BMD) in Chinese patients w...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023031742 |
| _version_ | 1797815585003798528 |
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| author | Yangli Ye Xilu Yi Yao Zhang Guiping Xu Mingxiang Yu Xinhua Qu |
| author_facet | Yangli Ye Xilu Yi Yao Zhang Guiping Xu Mingxiang Yu Xinhua Qu |
| author_sort | Yangli Ye |
| collection | DOAJ |
| description | Background: This study evaluated the association between renal function, assessed by serum creatinine and estimated glomerular filtration rate (eGFR) according to the Cockcroft–Gault (CG) and Modification of Diet in Renal Disease (MDRD) equations, and bone mineral density (BMD) in Chinese patients with type 2 diabetes mellitus (T2DM). Methods: 1322 patients with T2DM were included, and their basic clinical information, serum biochemical tests, and BMD at the total hip and femur neck were collected. Multivariate adjusted linear regression, smooth curve fitting and a piecewise linear regression model were used to analyze linear and nonlinear associations. Age, BMI, drinking, smoking, systolic blood pressure and diastolic blood pressure, FBG, HbA1C, course of diabetes, hsCRP, TC, TG, HDL-C, LDL-C, Ca, P, PTH, ALP, OC, P1NP, β-CTX and 25(OH)D were adjusted. Results: After adjusting the variables, no correlation between eGFR CG and eGFR MDRD and femur neck BMD was observed in women, men, or the total population. The eGFR CG and eGFR MDRD had a significant positive association with total hip BMD in men and the total population with T2DM. With a 10-unit decrease in eGFR CG, total hip BMD reduced by 0.012 g/cm2 in men and 0.010 g/cm2 the total population. Total hip BMD reduced by 0.014 g/cm2 in men and 0.022 g/cm2 in the total population with a 10-unit decrease in eGFR MDRD. There was no correlation between eGFR CG or eGFR MDRD and total hip BMD in female participants. Conclusion: Impaired renal function was associated with decreased total hip BMD in men and the total population with T2DM. No associated between renal function with femur neck BMD was observed. |
| first_indexed | 2024-03-13T08:25:01Z |
| format | Article |
| id | doaj.art-93f588e95d224819b5a95181cf418212 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:25:01Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-93f588e95d224819b5a95181cf4182122023-05-31T04:46:09ZengElsevierHeliyon2405-84402023-05-0195e15967Association between renal function and bone mineral density in patients with type 2 diabetes mellitusYangli Ye0Xilu Yi1Yao Zhang2Guiping Xu3Mingxiang Yu4Xinhua Qu5Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Endocrinology and Metabolism, Central Hospital of Songjiang District, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Infectious Disease, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China; VIP Clinical Department, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China; Corresponding author. Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, PR China.Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Corresponding author. Department of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Shandong Middle Road, Shanghai, 200120, PR China.Background: This study evaluated the association between renal function, assessed by serum creatinine and estimated glomerular filtration rate (eGFR) according to the Cockcroft–Gault (CG) and Modification of Diet in Renal Disease (MDRD) equations, and bone mineral density (BMD) in Chinese patients with type 2 diabetes mellitus (T2DM). Methods: 1322 patients with T2DM were included, and their basic clinical information, serum biochemical tests, and BMD at the total hip and femur neck were collected. Multivariate adjusted linear regression, smooth curve fitting and a piecewise linear regression model were used to analyze linear and nonlinear associations. Age, BMI, drinking, smoking, systolic blood pressure and diastolic blood pressure, FBG, HbA1C, course of diabetes, hsCRP, TC, TG, HDL-C, LDL-C, Ca, P, PTH, ALP, OC, P1NP, β-CTX and 25(OH)D were adjusted. Results: After adjusting the variables, no correlation between eGFR CG and eGFR MDRD and femur neck BMD was observed in women, men, or the total population. The eGFR CG and eGFR MDRD had a significant positive association with total hip BMD in men and the total population with T2DM. With a 10-unit decrease in eGFR CG, total hip BMD reduced by 0.012 g/cm2 in men and 0.010 g/cm2 the total population. Total hip BMD reduced by 0.014 g/cm2 in men and 0.022 g/cm2 in the total population with a 10-unit decrease in eGFR MDRD. There was no correlation between eGFR CG or eGFR MDRD and total hip BMD in female participants. Conclusion: Impaired renal function was associated with decreased total hip BMD in men and the total population with T2DM. No associated between renal function with femur neck BMD was observed.http://www.sciencedirect.com/science/article/pii/S2405844023031742Renal functionEstimated glomerular filtration rateTotal hipBone mineral densityType 2 diabetes mellitus |
| spellingShingle | Yangli Ye Xilu Yi Yao Zhang Guiping Xu Mingxiang Yu Xinhua Qu Association between renal function and bone mineral density in patients with type 2 diabetes mellitus Heliyon Renal function Estimated glomerular filtration rate Total hip Bone mineral density Type 2 diabetes mellitus |
| title | Association between renal function and bone mineral density in patients with type 2 diabetes mellitus |
| title_full | Association between renal function and bone mineral density in patients with type 2 diabetes mellitus |
| title_fullStr | Association between renal function and bone mineral density in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Association between renal function and bone mineral density in patients with type 2 diabetes mellitus |
| title_short | Association between renal function and bone mineral density in patients with type 2 diabetes mellitus |
| title_sort | association between renal function and bone mineral density in patients with type 2 diabetes mellitus |
| topic | Renal function Estimated glomerular filtration rate Total hip Bone mineral density Type 2 diabetes mellitus |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023031742 |
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