Assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction: a clinical trail
Objectives: Acute kidney injury (AKI) increases the risk of death following acute myocardial infarction (AMI). In this current study, we tried to understand the role of newly KDIGO defined AKI in AMI-induced early and late mortality. Methods: We retrospectively analyzed the clinical data of AMI pati...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Renal Failure |
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| Online Access: | http://dx.doi.org/10.1080/0886022X.2017.1419969 |
| _version_ | 1818961024538116096 |
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| author | Yan-Bei Sun Yuan Tao Min Yang |
| author_facet | Yan-Bei Sun Yuan Tao Min Yang |
| author_sort | Yan-Bei Sun |
| collection | DOAJ |
| description | Objectives: Acute kidney injury (AKI) increases the risk of death following acute myocardial infarction (AMI). In this current study, we tried to understand the role of newly KDIGO defined AKI in AMI-induced early and late mortality. Methods: We retrospectively analyzed the clinical data of AMI patients (totaling 1371 cases) from the hospital’s computer database. And AKI was defined based on the KDIGO criteria but GFR or urinary output assessment was not used. Subsequently, we compared the association of AKI with 30-day and 30-day to 5-year all-cause mortality, using multivariate COX regression analysis with two models. Results: We observed the development of AKI in 410 (29.9%) patients during the hospital stay. The 30-day and 30-day to 5-year mortality rates were 5.6% and 11.3%, respectively, in 1371 AMI patients. Further, adjusted Cox regression analysis based on model 1 revealed that AKI severity was an independent risk factor of 30-day mortality, while AKI Stage 3 was an independent predictor of 30-day to 5-year mortality. Adjusted Cox regression analysis based on model 2 revealed that normal baseline renal function with AKI and impaired renal function with AKI were independent risk factors of 30-day mortality, while normal baseline renal function with AKI and impaired renal function with AKI were identified to be independent predictors of 30-day to 5-year mortality. Conclusions: Whether the baseline renal function decreased or not, AKI strongly correlated with short- and long-term all-cause mortality in patients with AMI. Specifically, the short-term mortality of AMI patients increased with more severe AKI. |
| first_indexed | 2024-12-20T12:06:51Z |
| format | Article |
| id | doaj.art-93f5eaedfa2b4c39912d38283338387b |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-20T12:06:51Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-93f5eaedfa2b4c39912d38283338387b2022-12-21T19:41:21ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492018-10-01401758410.1080/0886022X.2017.14199691419969Assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction: a clinical trailYan-Bei Sun0Yuan Tao1Min Yang2The Affiliated Third Hospital of Soochow UniversityThe Affiliated Third Hospital of Soochow UniversityThe Affiliated Third Hospital of Soochow UniversityObjectives: Acute kidney injury (AKI) increases the risk of death following acute myocardial infarction (AMI). In this current study, we tried to understand the role of newly KDIGO defined AKI in AMI-induced early and late mortality. Methods: We retrospectively analyzed the clinical data of AMI patients (totaling 1371 cases) from the hospital’s computer database. And AKI was defined based on the KDIGO criteria but GFR or urinary output assessment was not used. Subsequently, we compared the association of AKI with 30-day and 30-day to 5-year all-cause mortality, using multivariate COX regression analysis with two models. Results: We observed the development of AKI in 410 (29.9%) patients during the hospital stay. The 30-day and 30-day to 5-year mortality rates were 5.6% and 11.3%, respectively, in 1371 AMI patients. Further, adjusted Cox regression analysis based on model 1 revealed that AKI severity was an independent risk factor of 30-day mortality, while AKI Stage 3 was an independent predictor of 30-day to 5-year mortality. Adjusted Cox regression analysis based on model 2 revealed that normal baseline renal function with AKI and impaired renal function with AKI were independent risk factors of 30-day mortality, while normal baseline renal function with AKI and impaired renal function with AKI were identified to be independent predictors of 30-day to 5-year mortality. Conclusions: Whether the baseline renal function decreased or not, AKI strongly correlated with short- and long-term all-cause mortality in patients with AMI. Specifically, the short-term mortality of AMI patients increased with more severe AKI.http://dx.doi.org/10.1080/0886022X.2017.1419969Acute kidney injurymortalityKDIGObaseline GFRacute myocardial infarction |
| spellingShingle | Yan-Bei Sun Yuan Tao Min Yang Assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction: a clinical trail Renal Failure Acute kidney injury mortality KDIGO baseline GFR acute myocardial infarction |
| title | Assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction: a clinical trail |
| title_full | Assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction: a clinical trail |
| title_fullStr | Assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction: a clinical trail |
| title_full_unstemmed | Assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction: a clinical trail |
| title_short | Assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction: a clinical trail |
| title_sort | assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction a clinical trail |
| topic | Acute kidney injury mortality KDIGO baseline GFR acute myocardial infarction |
| url | http://dx.doi.org/10.1080/0886022X.2017.1419969 |
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