An insight on the role of genetic testing of RUNX1: A key transcriptional gene in familial platelet disorder with predisposition to acute myeloid leukemia

An insight on the role of genetic testing of RUNX1: A key transcriptional gene in familial platelet disorder with predisposition to acute myeloid leukemia

Background: Familial platelet disorder (FPD) with predisposition to acute myeloid leukemia (AML) is an autosomal dominant disease of the hematopoietic system that is caused by heterozygous mutations in RUNX1 gene. RUNX1 is frequently involved in the pathogenesis of sporadic leukemia and myelodysplas...

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Bibliographic Details
Main Authors: Intezar Mehdi, K. Ramya, T.L. Suma, Ashraf Mannan, M.L. Sheela, Shanmukh Kattragada, B.S. Ajaikumar, Mithua Ghosh
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Pediatric Hematology Oncology Journal
Subjects:
FPD/AML
RUNX1
Germline test
Mutation specific test
Genetic counselling
Online Access:http://www.sciencedirect.com/science/article/pii/S2468124523000098

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