Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults
Background: The utility of muscle health for predicting asymptomatic vertebral fracture (VF) is uncertain. We aimed to determine the effects of muscle health on bone quantity and quality in the older adults and to integrate these factors into a predictive model for VF. Methods: We prospectively recr...
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/5/1129 |
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| author | Yu-Ching Lin Yu-Hsiang Juan Wing P. Chan Kun-Yun Yeh Alice M. K. Wong Chen-Ming Sung Yu-Jr Lin Shu-Chen Chang Fang-Ping Chen |
| author_facet | Yu-Ching Lin Yu-Hsiang Juan Wing P. Chan Kun-Yun Yeh Alice M. K. Wong Chen-Ming Sung Yu-Jr Lin Shu-Chen Chang Fang-Ping Chen |
| author_sort | Yu-Ching Lin |
| collection | DOAJ |
| description | Background: The utility of muscle health for predicting asymptomatic vertebral fracture (VF) is uncertain. We aimed to determine the effects of muscle health on bone quantity and quality in the older adults and to integrate these factors into a predictive model for VF. Methods: We prospectively recruited participants with a body mass index <37 kg/m<sup>2</sup>. The total lean mass (TLM), appendicular skeletal muscle index, presence of sarcopenia, and bone mineral density were determined by dual-energy X-ray absorptiometry, and bone quality by the trabecular bone score (TBS). VF was diagnosed based on spine radiography. Results: A total of 414 females and 186 males were included; 257 participants had VF. Lower TLM was significantly associated with poorer bone quantity and quality in both males and females. A low TBS (OR: 11.302, <i>p</i> = 0.028) and sarcopenia (Odds ratio (OR): 2.820, <i>p</i> = 0.002) were significant predictors of VF in males, but not bone quantity. Moreover, integrating TBS and sarcopenia into the predictive model improved its performance. Conclusions: Although TLM was associated with bone quantity and quality in both sexes, sarcopenia and a low TBS were significant predictors of asymptomatic VF only in male participants. |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:26:15Z |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-93f698a7cec74da99005da1d4b2128812023-11-21T09:36:53ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01105112910.3390/jcm10051129Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older AdultsYu-Ching Lin0Yu-Hsiang Juan1Wing P. Chan2Kun-Yun Yeh3Alice M. K. Wong4Chen-Ming Sung5Yu-Jr Lin6Shu-Chen Chang7Fang-Ping Chen8Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Keelung, College of Medicine, Chang Gung University, Keelung 222, TaiwanDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Taoyuan, Institute for Radiological Research, Chang Gung University, Taoyuan 333, TaiwanDepartment of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, TaiwanDepartment of Internal Medicine, Division of Hemato-Oncology, Chang Gung Memorial Hospital, College of Medicine, Keelung & Chang Gung University, Keelung 222, TaiwanDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Taoyuan, Taoyuan 333, TaiwanDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Keelung, College of Medicine, Chang Gung University, Keelung 222, TaiwanResearch Services Center for Health Information, Chang Gung University, Taoyuan 333, TaiwanResearch Services Center for Health Information, Chang Gung University, Taoyuan 333, TaiwanDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Keelung and Chang Gung University, Keelung 222, TaiwanBackground: The utility of muscle health for predicting asymptomatic vertebral fracture (VF) is uncertain. We aimed to determine the effects of muscle health on bone quantity and quality in the older adults and to integrate these factors into a predictive model for VF. Methods: We prospectively recruited participants with a body mass index <37 kg/m<sup>2</sup>. The total lean mass (TLM), appendicular skeletal muscle index, presence of sarcopenia, and bone mineral density were determined by dual-energy X-ray absorptiometry, and bone quality by the trabecular bone score (TBS). VF was diagnosed based on spine radiography. Results: A total of 414 females and 186 males were included; 257 participants had VF. Lower TLM was significantly associated with poorer bone quantity and quality in both males and females. A low TBS (OR: 11.302, <i>p</i> = 0.028) and sarcopenia (Odds ratio (OR): 2.820, <i>p</i> = 0.002) were significant predictors of VF in males, but not bone quantity. Moreover, integrating TBS and sarcopenia into the predictive model improved its performance. Conclusions: Although TLM was associated with bone quantity and quality in both sexes, sarcopenia and a low TBS were significant predictors of asymptomatic VF only in male participants.https://www.mdpi.com/2077-0383/10/5/1129vertebral fracturesarcopeniabone quantitybone qualityfracture risk |
| spellingShingle | Yu-Ching Lin Yu-Hsiang Juan Wing P. Chan Kun-Yun Yeh Alice M. K. Wong Chen-Ming Sung Yu-Jr Lin Shu-Chen Chang Fang-Ping Chen Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults Journal of Clinical Medicine vertebral fracture sarcopenia bone quantity bone quality fracture risk |
| title | Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults |
| title_full | Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults |
| title_fullStr | Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults |
| title_full_unstemmed | Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults |
| title_short | Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults |
| title_sort | integrating muscle health in predicting the risk of asymptomatic vertebral fracture in older adults |
| topic | vertebral fracture sarcopenia bone quantity bone quality fracture risk |
| url | https://www.mdpi.com/2077-0383/10/5/1129 |
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