Comparative efficacy of ternary Cu (II) complex and Zn (II)-complex in amelioration of carbon tetrachloride-induced hepatotoxicity in vivo
Cu (II) and Zn (II) are two of the most favored metals in synthesis chemistry, encompassing their therapeutic potentials. The present study aims to evaluate the comparative ameliorative potential of a group B carcinogen, CCl4-induced hepatotoxicity, by our recently synthesized and characterized tern...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of King Saud University: Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364722006012 |
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| author | Iftekhar Hassan Rais Ahmad Khan Jameel Al-Tamimi Hossam Ebaid Fohad Mabood Husain Ibrahim M. Alhazza |
| author_facet | Iftekhar Hassan Rais Ahmad Khan Jameel Al-Tamimi Hossam Ebaid Fohad Mabood Husain Ibrahim M. Alhazza |
| author_sort | Iftekhar Hassan |
| collection | DOAJ |
| description | Cu (II) and Zn (II) are two of the most favored metals in synthesis chemistry, encompassing their therapeutic potentials. The present study aims to evaluate the comparative ameliorative potential of a group B carcinogen, CCl4-induced hepatotoxicity, by our recently synthesized and characterized ternary Cu and Zn-based complexes in vivo. Three groups of rats were treated with CCl4 alone and with the combination of Cu (II) complex and Zn (II) complex beside the control negative group without any treatment. After completion of the treatment, the samples were subjected to biochemical and histological analysis. The analysis demonstrated extensive alteration in redox status, liver markers, and hepatotoxicity markers in the CCl4, treated group compared to the control group. However, the Cu (II) complex showed significant improvement in most of the parameters under the study. Also, histopathological evaluation and comet assay further consolidated the findings. Hence, this investigation reveals that Cu (II) complex has more substantial ameliorative potential in ceasing CCl4-induced hepatotoxic insults. Therefore, the ternary Cu (II) complex act as a more potent chemotherapeutic agent in cancer treatment with milder side effects than the Zn (II) complex. |
| first_indexed | 2024-04-12T01:41:49Z |
| format | Article |
| id | doaj.art-93f7344df00d4004807760dee04eda2e |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-04-12T01:41:49Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-93f7344df00d4004807760dee04eda2e2022-12-22T03:53:11ZengElsevierJournal of King Saud University: Science1018-36472023-01-01351102420Comparative efficacy of ternary Cu (II) complex and Zn (II)-complex in amelioration of carbon tetrachloride-induced hepatotoxicity in vivoIftekhar Hassan0Rais Ahmad Khan1Jameel Al-Tamimi2Hossam Ebaid3Fohad Mabood Husain4Ibrahim M. Alhazza5Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Corresponding author at: Department of Zoology, College of Science, King Saud University, Building 05, Riyadh 11451, Saudi Arabia.Cu (II) and Zn (II) are two of the most favored metals in synthesis chemistry, encompassing their therapeutic potentials. The present study aims to evaluate the comparative ameliorative potential of a group B carcinogen, CCl4-induced hepatotoxicity, by our recently synthesized and characterized ternary Cu and Zn-based complexes in vivo. Three groups of rats were treated with CCl4 alone and with the combination of Cu (II) complex and Zn (II) complex beside the control negative group without any treatment. After completion of the treatment, the samples were subjected to biochemical and histological analysis. The analysis demonstrated extensive alteration in redox status, liver markers, and hepatotoxicity markers in the CCl4, treated group compared to the control group. However, the Cu (II) complex showed significant improvement in most of the parameters under the study. Also, histopathological evaluation and comet assay further consolidated the findings. Hence, this investigation reveals that Cu (II) complex has more substantial ameliorative potential in ceasing CCl4-induced hepatotoxic insults. Therefore, the ternary Cu (II) complex act as a more potent chemotherapeutic agent in cancer treatment with milder side effects than the Zn (II) complex.http://www.sciencedirect.com/science/article/pii/S1018364722006012CopperZincMetal complexCarbon tetrachlorideHepatotoxicity |
| spellingShingle | Iftekhar Hassan Rais Ahmad Khan Jameel Al-Tamimi Hossam Ebaid Fohad Mabood Husain Ibrahim M. Alhazza Comparative efficacy of ternary Cu (II) complex and Zn (II)-complex in amelioration of carbon tetrachloride-induced hepatotoxicity in vivo Journal of King Saud University: Science Copper Zinc Metal complex Carbon tetrachloride Hepatotoxicity |
| title | Comparative efficacy of ternary Cu (II) complex and Zn (II)-complex in amelioration of carbon tetrachloride-induced hepatotoxicity in vivo |
| title_full | Comparative efficacy of ternary Cu (II) complex and Zn (II)-complex in amelioration of carbon tetrachloride-induced hepatotoxicity in vivo |
| title_fullStr | Comparative efficacy of ternary Cu (II) complex and Zn (II)-complex in amelioration of carbon tetrachloride-induced hepatotoxicity in vivo |
| title_full_unstemmed | Comparative efficacy of ternary Cu (II) complex and Zn (II)-complex in amelioration of carbon tetrachloride-induced hepatotoxicity in vivo |
| title_short | Comparative efficacy of ternary Cu (II) complex and Zn (II)-complex in amelioration of carbon tetrachloride-induced hepatotoxicity in vivo |
| title_sort | comparative efficacy of ternary cu ii complex and zn ii complex in amelioration of carbon tetrachloride induced hepatotoxicity in vivo |
| topic | Copper Zinc Metal complex Carbon tetrachloride Hepatotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S1018364722006012 |
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