Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens
Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism. In the present study, we investigated the possible involvement of central TGF-β/Smad signa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Japan Poultry Science Association
2022-10-01
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| Series: | The Journal of Poultry Science |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/59/4/59_0220040/_article/-char/en |
| _version_ | 1797817441696350208 |
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| author | Takaoki Saneyasu Miku Ueda Kanami Nagata Jiawei Chai Kazuhisa Honda Hiroshi Kamisoyama |
| author_facet | Takaoki Saneyasu Miku Ueda Kanami Nagata Jiawei Chai Kazuhisa Honda Hiroshi Kamisoyama |
| author_sort | Takaoki Saneyasu |
| collection | DOAJ |
| description | Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism. In the present study, we investigated the possible involvement of central TGF-β/Smad signaling in feeding regulation in chickens. Central administration of TGF-β1 resulted in phosphorylation of Smad2 in the hypothalamus of chicks and suppressed feed intake without changing the gene expression of hypothalamic appetite-regulating neuropeptides (neuropeptide Y, agouti-related protein, proopiomelanocortin, and corticotropin-releasing factor). However, neither fasting nor refeeding induced the phosphorylation of hypothalamic Smad2. These findings suggest that the activation of hypothalamic TGF-β/Smad signaling suppresses feed intake in chicks but it might not occur in response to feeding status. |
| first_indexed | 2024-03-13T08:53:26Z |
| format | Article |
| id | doaj.art-93f8ae48b1134ed299edf9529580a9ba |
| institution | Directory Open Access Journal |
| issn | 1349-0486 |
| language | English |
| last_indexed | 2024-03-13T08:53:26Z |
| publishDate | 2022-10-01 |
| publisher | Japan Poultry Science Association |
| record_format | Article |
| series | The Journal of Poultry Science |
| spelling | doaj.art-93f8ae48b1134ed299edf9529580a9ba2023-05-29T07:11:12ZengJapan Poultry Science AssociationThe Journal of Poultry Science1349-04862022-10-01594357363https://doi.org/10.2141/jpsa.0220040Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in ChickensTakaoki Saneyasu0Miku Ueda1Kanami Nagata2Jiawei Chai3Kazuhisa Honda4Hiroshi Kamisoyama5Graduate School of Agricultural Science, Kobe UniversityGraduate School of Agricultural Science, Kobe UniversityGraduate School of Agricultural Science, Kobe UniversityGraduate School of Agricultural Science, Kobe UniversityGraduate School of Agricultural Science, Kobe UniversityGraduate School of Agricultural Science, Kobe UniversityPrevious studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism. In the present study, we investigated the possible involvement of central TGF-β/Smad signaling in feeding regulation in chickens. Central administration of TGF-β1 resulted in phosphorylation of Smad2 in the hypothalamus of chicks and suppressed feed intake without changing the gene expression of hypothalamic appetite-regulating neuropeptides (neuropeptide Y, agouti-related protein, proopiomelanocortin, and corticotropin-releasing factor). However, neither fasting nor refeeding induced the phosphorylation of hypothalamic Smad2. These findings suggest that the activation of hypothalamic TGF-β/Smad signaling suppresses feed intake in chicks but it might not occur in response to feeding status.https://www.jstage.jst.go.jp/article/jpsa/59/4/59_0220040/_article/-char/enchickensfood intakehypothalamussmadtransforming growth factor-β |
| spellingShingle | Takaoki Saneyasu Miku Ueda Kanami Nagata Jiawei Chai Kazuhisa Honda Hiroshi Kamisoyama Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens The Journal of Poultry Science chickens food intake hypothalamus smad transforming growth factor-β |
| title | Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens |
| title_full | Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens |
| title_fullStr | Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens |
| title_full_unstemmed | Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens |
| title_short | Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens |
| title_sort | role of hypothalamic transforming growth factor β tgf β smad signaling in feeding regulation in chickens |
| topic | chickens food intake hypothalamus smad transforming growth factor-β |
| url | https://www.jstage.jst.go.jp/article/jpsa/59/4/59_0220040/_article/-char/en |
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