Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications
Targeted and controlled drug delivery employing “smart materials” is a widely investigated field, within which stimuli-responsive polymers, particularly those which are thermo-responsive, have received considerable attention. Thermo-responsive polymers have facilitated the formulation of in situ gel...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Materials |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmats.2020.00073/full |
| _version_ | 1819147717648056320 |
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| author | Taskeen Sarwan Pradeep Kumar Yahya E. Choonara Viness Pillay |
| author_facet | Taskeen Sarwan Pradeep Kumar Yahya E. Choonara Viness Pillay |
| author_sort | Taskeen Sarwan |
| collection | DOAJ |
| description | Targeted and controlled drug delivery employing “smart materials” is a widely investigated field, within which stimuli-responsive polymers, particularly those which are thermo-responsive, have received considerable attention. Thermo-responsive polymers have facilitated the formulation of in situ gel forming systems which undergo a sol-gel transition at physiological body temperature, and have revolutionized the fields of tissue engineering, cell encapsulation, and controlled, sustained delivery of both drugs and genes. However, the use of single thermo-responsive polymers in the creation of these systems has posed numerous problems in terms of physico-mechanical properties, such as poor mechanical strength, high critical gelation concentrations (CGC) resulting in increased production costs and solutions that are too viscous, toxicity, as well as gelation temperatures that are incompatible with physiological body temperatures. Hybridization of these thermo-responsive polymers with other polymers has therefore been employed, resulting in the creation of tailor-made drug delivery systems that have optimal gelation temperatures and concentrations, ideal viscosities and improved gel strengths. This article reviews various thermo-responsive polymers that have been employed in the formulation of thermo-gelling systems. Special attention has been given to the hybridization of each of these polymers, the resulting systems that have been created, and their biomedical applications. |
| first_indexed | 2024-12-22T13:34:16Z |
| format | Article |
| id | doaj.art-93f9156c9afc402a89a3aecab8b5e16c |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-12-22T13:34:16Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-93f9156c9afc402a89a3aecab8b5e16c2022-12-21T18:24:07ZengFrontiers Media S.A.Frontiers in Materials2296-80162020-03-01710.3389/fmats.2020.00073514673Hybrid Thermo-Responsive Polymer Systems and Their Biomedical ApplicationsTaskeen SarwanPradeep KumarYahya E. ChoonaraViness PillayTargeted and controlled drug delivery employing “smart materials” is a widely investigated field, within which stimuli-responsive polymers, particularly those which are thermo-responsive, have received considerable attention. Thermo-responsive polymers have facilitated the formulation of in situ gel forming systems which undergo a sol-gel transition at physiological body temperature, and have revolutionized the fields of tissue engineering, cell encapsulation, and controlled, sustained delivery of both drugs and genes. However, the use of single thermo-responsive polymers in the creation of these systems has posed numerous problems in terms of physico-mechanical properties, such as poor mechanical strength, high critical gelation concentrations (CGC) resulting in increased production costs and solutions that are too viscous, toxicity, as well as gelation temperatures that are incompatible with physiological body temperatures. Hybridization of these thermo-responsive polymers with other polymers has therefore been employed, resulting in the creation of tailor-made drug delivery systems that have optimal gelation temperatures and concentrations, ideal viscosities and improved gel strengths. This article reviews various thermo-responsive polymers that have been employed in the formulation of thermo-gelling systems. Special attention has been given to the hybridization of each of these polymers, the resulting systems that have been created, and their biomedical applications.https://www.frontiersin.org/article/10.3389/fmats.2020.00073/fullthermo-responsive polymershybridchitosan-β-glycerophosphatepNIPAAmpluroniccellulose |
| spellingShingle | Taskeen Sarwan Pradeep Kumar Yahya E. Choonara Viness Pillay Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications Frontiers in Materials thermo-responsive polymers hybrid chitosan-β-glycerophosphate pNIPAAm pluronic cellulose |
| title | Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications |
| title_full | Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications |
| title_fullStr | Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications |
| title_full_unstemmed | Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications |
| title_short | Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications |
| title_sort | hybrid thermo responsive polymer systems and their biomedical applications |
| topic | thermo-responsive polymers hybrid chitosan-β-glycerophosphate pNIPAAm pluronic cellulose |
| url | https://www.frontiersin.org/article/10.3389/fmats.2020.00073/full |
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