Genetic dissection of MHC-associated susceptibility to <it>Lepeophtheirus salmonis </it>in Atlantic salmon
<p>Abstract</p> <p>Background</p> <p>Genetic variation has been shown to play a significant role in determining susceptibility to the salmon louse, <it>Lepeophtheirus salmonis</it>. However, the mechanisms involved in differential response to infection remai...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-04-01
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| Series: | BMC Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2156/10/20 |
| _version_ | 1811290960788717568 |
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| author | MacDonald Elizabeth S Stone Louise C Glover Kevin A Gharbi Karim Matthews Louise Grimholt Unni Stear Michael J |
| author_facet | MacDonald Elizabeth S Stone Louise C Glover Kevin A Gharbi Karim Matthews Louise Grimholt Unni Stear Michael J |
| author_sort | MacDonald Elizabeth S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Genetic variation has been shown to play a significant role in determining susceptibility to the salmon louse, <it>Lepeophtheirus salmonis</it>. However, the mechanisms involved in differential response to infection remain poorly understood. Recent findings in Atlantic salmon (<it>Salmo salar</it>) have provided evidence for a potential link between marker variation at the major histocompatibility complex (MHC) and differences in lice abundance among infected siblings, suggesting that MHC genes can modulate susceptibility to the parasite. In this study, we used quantitative trait locus (QTL) analysis to test the effect of genomic regions linked to MHC class I and II on linkage groups (LG) 15 and 6, respectively.</p> <p>Results</p> <p>Significant QTL effects were detected on both LG 6 and LG 15 in sire-based analysis but the QTL regions remained unresolved due to a lack of recombination between markers. In dam-based analysis, a significant QTL was identified on LG 6, which accounted for 12.9% of within-family variance in lice abundance. However, the QTL was located at the opposite end of <it>DAA</it>, with no significant overlap with the MHC class II region. Interestingly, QTL modelling also revealed evidence of sex-linked differences in lice abundance, indicating that males and females may have different susceptibility to infection.</p> <p>Conclusion</p> <p>Overall, QTL analysis provided relatively weak support for a proximal effect of classical MHC regions on lice abundance, which can partly be explained by linkage to other genes controlling susceptibility to <it>L. salmonis </it>on the same chromosome.</p> |
| first_indexed | 2024-04-13T04:22:17Z |
| format | Article |
| id | doaj.art-93f98288a3fc4789aac150d558aae936 |
| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-04-13T04:22:17Z |
| publishDate | 2009-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genetics |
| spelling | doaj.art-93f98288a3fc4789aac150d558aae9362022-12-22T03:02:41ZengBMCBMC Genetics1471-21562009-04-011012010.1186/1471-2156-10-20Genetic dissection of MHC-associated susceptibility to <it>Lepeophtheirus salmonis </it>in Atlantic salmonMacDonald Elizabeth SStone Louise CGlover Kevin AGharbi KarimMatthews LouiseGrimholt UnniStear Michael J<p>Abstract</p> <p>Background</p> <p>Genetic variation has been shown to play a significant role in determining susceptibility to the salmon louse, <it>Lepeophtheirus salmonis</it>. However, the mechanisms involved in differential response to infection remain poorly understood. Recent findings in Atlantic salmon (<it>Salmo salar</it>) have provided evidence for a potential link between marker variation at the major histocompatibility complex (MHC) and differences in lice abundance among infected siblings, suggesting that MHC genes can modulate susceptibility to the parasite. In this study, we used quantitative trait locus (QTL) analysis to test the effect of genomic regions linked to MHC class I and II on linkage groups (LG) 15 and 6, respectively.</p> <p>Results</p> <p>Significant QTL effects were detected on both LG 6 and LG 15 in sire-based analysis but the QTL regions remained unresolved due to a lack of recombination between markers. In dam-based analysis, a significant QTL was identified on LG 6, which accounted for 12.9% of within-family variance in lice abundance. However, the QTL was located at the opposite end of <it>DAA</it>, with no significant overlap with the MHC class II region. Interestingly, QTL modelling also revealed evidence of sex-linked differences in lice abundance, indicating that males and females may have different susceptibility to infection.</p> <p>Conclusion</p> <p>Overall, QTL analysis provided relatively weak support for a proximal effect of classical MHC regions on lice abundance, which can partly be explained by linkage to other genes controlling susceptibility to <it>L. salmonis </it>on the same chromosome.</p>http://www.biomedcentral.com/1471-2156/10/20 |
| spellingShingle | MacDonald Elizabeth S Stone Louise C Glover Kevin A Gharbi Karim Matthews Louise Grimholt Unni Stear Michael J Genetic dissection of MHC-associated susceptibility to <it>Lepeophtheirus salmonis </it>in Atlantic salmon BMC Genetics |
| title | Genetic dissection of MHC-associated susceptibility to <it>Lepeophtheirus salmonis </it>in Atlantic salmon |
| title_full | Genetic dissection of MHC-associated susceptibility to <it>Lepeophtheirus salmonis </it>in Atlantic salmon |
| title_fullStr | Genetic dissection of MHC-associated susceptibility to <it>Lepeophtheirus salmonis </it>in Atlantic salmon |
| title_full_unstemmed | Genetic dissection of MHC-associated susceptibility to <it>Lepeophtheirus salmonis </it>in Atlantic salmon |
| title_short | Genetic dissection of MHC-associated susceptibility to <it>Lepeophtheirus salmonis </it>in Atlantic salmon |
| title_sort | genetic dissection of mhc associated susceptibility to it lepeophtheirus salmonis it in atlantic salmon |
| url | http://www.biomedcentral.com/1471-2156/10/20 |
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