Outcomes of Geriatric Patients with Hepatocellular Carcinoma
Background: The treatment modalities and outcomes of geriatric patients with hepatocellular carcinoma (HCC) remain controversial. This retrospective observational cohort study compared the outcomes of HCC between geriatric and younger patients. Methods: The medical records of patients with HCC manag...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/6/346 |
| _version_ | 1797488455175897088 |
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| author | Chern-Horng Lee Tzung-Hai Yen Sen-Yung Hsieh |
| author_facet | Chern-Horng Lee Tzung-Hai Yen Sen-Yung Hsieh |
| author_sort | Chern-Horng Lee |
| collection | DOAJ |
| description | Background: The treatment modalities and outcomes of geriatric patients with hepatocellular carcinoma (HCC) remain controversial. This retrospective observational cohort study compared the outcomes of HCC between geriatric and younger patients. Methods: The medical records of patients with HCC managed between January 2001 and December 2017 were retrieved from the Chang Gung Memorial Hospital Research Database. Patients were stratified by age into two groups: a geriatric group (65–75 years) and a younger group (<65 years). The two groups were matched through 1:2 propensity score matching (PSM) according to sex, cardiovascular disease, cerebrovascular attack, diabetes mellitus, cirrhosis, hepatitis, and hypertension. Results: Of the 11,033 patients with HCC, 2147 patients aged 65–75 years and 4294 patients aged <65 years were identified after 1:2 PSM. The Kaplan–Meier model revealed that the HCC outcomes in patients older than 65 years were not significantly different after 3 years (<i>p</i> = 0.060). Consistent results were also obtained when the laboratory data associated with HCC incidence were included in the Fine–Gray competing risk model after 1:2 PSM (<i>p</i> = 0.1695). The major risk factors for HCC survival were systemic immune-inflammation index (SII) ≥ 610 × 10<sup>9</sup> cells/L, advanced tumor stage, and model for end-stage liver disease (MELD) score, etc. Conclusion: Age was not an independent factor for mortality in patients with HCC in the first 3 years. Geriatric patients with HCC should be as aggressively managed as younger patients. |
| first_indexed | 2024-03-10T00:02:29Z |
| format | Article |
| id | doaj.art-9400802672c64ea686c75ce12161e2df |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T00:02:29Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-9400802672c64ea686c75ce12161e2df2023-11-23T16:14:21ZengMDPI AGCurrent Oncology1198-00521718-77292022-06-012964332434110.3390/curroncol29060346Outcomes of Geriatric Patients with Hepatocellular CarcinomaChern-Horng Lee0Tzung-Hai Yen1Sen-Yung Hsieh2Division of General Internal Medicine and Geriatrics, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanDepartment of Nephrology, Clinical Poison Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333, TaiwanBackground: The treatment modalities and outcomes of geriatric patients with hepatocellular carcinoma (HCC) remain controversial. This retrospective observational cohort study compared the outcomes of HCC between geriatric and younger patients. Methods: The medical records of patients with HCC managed between January 2001 and December 2017 were retrieved from the Chang Gung Memorial Hospital Research Database. Patients were stratified by age into two groups: a geriatric group (65–75 years) and a younger group (<65 years). The two groups were matched through 1:2 propensity score matching (PSM) according to sex, cardiovascular disease, cerebrovascular attack, diabetes mellitus, cirrhosis, hepatitis, and hypertension. Results: Of the 11,033 patients with HCC, 2147 patients aged 65–75 years and 4294 patients aged <65 years were identified after 1:2 PSM. The Kaplan–Meier model revealed that the HCC outcomes in patients older than 65 years were not significantly different after 3 years (<i>p</i> = 0.060). Consistent results were also obtained when the laboratory data associated with HCC incidence were included in the Fine–Gray competing risk model after 1:2 PSM (<i>p</i> = 0.1695). The major risk factors for HCC survival were systemic immune-inflammation index (SII) ≥ 610 × 10<sup>9</sup> cells/L, advanced tumor stage, and model for end-stage liver disease (MELD) score, etc. Conclusion: Age was not an independent factor for mortality in patients with HCC in the first 3 years. Geriatric patients with HCC should be as aggressively managed as younger patients.https://www.mdpi.com/1718-7729/29/6/346hepatocellular carcinomageriatric patientsmortality |
| spellingShingle | Chern-Horng Lee Tzung-Hai Yen Sen-Yung Hsieh Outcomes of Geriatric Patients with Hepatocellular Carcinoma Current Oncology hepatocellular carcinoma geriatric patients mortality |
| title | Outcomes of Geriatric Patients with Hepatocellular Carcinoma |
| title_full | Outcomes of Geriatric Patients with Hepatocellular Carcinoma |
| title_fullStr | Outcomes of Geriatric Patients with Hepatocellular Carcinoma |
| title_full_unstemmed | Outcomes of Geriatric Patients with Hepatocellular Carcinoma |
| title_short | Outcomes of Geriatric Patients with Hepatocellular Carcinoma |
| title_sort | outcomes of geriatric patients with hepatocellular carcinoma |
| topic | hepatocellular carcinoma geriatric patients mortality |
| url | https://www.mdpi.com/1718-7729/29/6/346 |
| work_keys_str_mv | AT chernhornglee outcomesofgeriatricpatientswithhepatocellularcarcinoma AT tzunghaiyen outcomesofgeriatricpatientswithhepatocellularcarcinoma AT senyunghsieh outcomesofgeriatricpatientswithhepatocellularcarcinoma |