The effect of a single-strain probiotic administration in the treatment of thermal burns patients
Background and Objectives: Between 2007 and 2011, the mortality rate for burns patients at Dr. Soetomo General Hospital, Surabaya, Indonesia was 14.1% and 60% were suspected to be sepsis-related. Immunosuppression, gut barrier disruption, and intestinal hypomotility cause bacterial and bacterial pro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2019-07-01
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| Series: | Iranian Journal of Microbiology |
| Subjects: | |
| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/2074 |
| _version_ | 1818389723142422528 |
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| author | David S. Perdanakusuma Lynda Hariani Nur Febriany Nasser Robertus Arian Datusanantyo |
| author_facet | David S. Perdanakusuma Lynda Hariani Nur Febriany Nasser Robertus Arian Datusanantyo |
| author_sort | David S. Perdanakusuma |
| collection | DOAJ |
| description | Background and Objectives: Between 2007 and 2011, the mortality rate for burns patients at Dr. Soetomo General Hospital, Surabaya, Indonesia was 14.1% and 60% were suspected to be sepsis-related. Immunosuppression, gut barrier disruption, and intestinal hypomotility cause bacterial and bacterial product translocation. Probiotics improve the intestinal microbiome and eventually reduce bacterial translocation, and an increased secretory immunoglobulin A (SIgA) secretion post-administration of a multi-species probiotic has been observed. We aimed to determine whether a single-strain probiotic administration could show strengthened intestinal immunity, through an increase in SIgA levels, as with multi-strain probiotics.
Materials and Methods: Sixteen burns patients from our hospital Burns Centre were randomized into three treatment groups, and the patients were administered either a placebo, a Lactobacillus reuteri protectis probiotic, or a Bifidobacterium infantis 35624 probiotic for 14 consecutive days. The SIgA levels were analyzed using ELISA pre- and post-treatment.
Results: The post-treatment SIgA levels in the placebo, Lactobacillus reuteri protectis probiotic, and Bifidobacterium infantis 35624 probiotic groups were 222.56±74.22 mg/dL, 223.92±68.89 mg/dL, and 332.38±64.27 mg/dL, respectively. Decreased SIgA levels were observed in the placebo (7.19±15.87) and in the Lactobacillus reuteri protectis probiotic (1.9920±14.76) groups, whereas an increase was seen in the SIgA level in the Bifidobacterium infantis 35624 probiotic group (58.26±77.41).
Conclusion: The Bifidobacterium infantis 35624 single-strain probiotic is generally superior to Lactobacillus reuteri protectis in altering intestinal immunity; however, this finding was not statistically significant. A multi-strain probiotic supplement is recommended for burns patients. |
| first_indexed | 2024-12-14T04:46:16Z |
| format | Article |
| id | doaj.art-9400d841456741928122cc4be702d532 |
| institution | Directory Open Access Journal |
| issn | 2008-3289 2008-4447 |
| language | English |
| last_indexed | 2024-12-14T04:46:16Z |
| publishDate | 2019-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj.art-9400d841456741928122cc4be702d5322022-12-21T23:16:40ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472019-07-0111310.18502/ijm.v11i3.1335The effect of a single-strain probiotic administration in the treatment of thermal burns patientsDavid S. Perdanakusuma0Lynda Hariani1Nur Febriany Nasser2Robertus Arian Datusanantyo3Department of Plastic Reconstructive and Aesthetic Surgery, School of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, IndonesiaDepartment of Plastic Reconstructive and Aesthetic Surgery, School of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, IndonesiaDepartment of Plastic Reconstructive and Aesthetic Surgery, School of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, IndonesiaDepartment of Plastic Reconstructive and Aesthetic Surgery, School of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, IndonesiaBackground and Objectives: Between 2007 and 2011, the mortality rate for burns patients at Dr. Soetomo General Hospital, Surabaya, Indonesia was 14.1% and 60% were suspected to be sepsis-related. Immunosuppression, gut barrier disruption, and intestinal hypomotility cause bacterial and bacterial product translocation. Probiotics improve the intestinal microbiome and eventually reduce bacterial translocation, and an increased secretory immunoglobulin A (SIgA) secretion post-administration of a multi-species probiotic has been observed. We aimed to determine whether a single-strain probiotic administration could show strengthened intestinal immunity, through an increase in SIgA levels, as with multi-strain probiotics. Materials and Methods: Sixteen burns patients from our hospital Burns Centre were randomized into three treatment groups, and the patients were administered either a placebo, a Lactobacillus reuteri protectis probiotic, or a Bifidobacterium infantis 35624 probiotic for 14 consecutive days. The SIgA levels were analyzed using ELISA pre- and post-treatment. Results: The post-treatment SIgA levels in the placebo, Lactobacillus reuteri protectis probiotic, and Bifidobacterium infantis 35624 probiotic groups were 222.56±74.22 mg/dL, 223.92±68.89 mg/dL, and 332.38±64.27 mg/dL, respectively. Decreased SIgA levels were observed in the placebo (7.19±15.87) and in the Lactobacillus reuteri protectis probiotic (1.9920±14.76) groups, whereas an increase was seen in the SIgA level in the Bifidobacterium infantis 35624 probiotic group (58.26±77.41). Conclusion: The Bifidobacterium infantis 35624 single-strain probiotic is generally superior to Lactobacillus reuteri protectis in altering intestinal immunity; however, this finding was not statistically significant. A multi-strain probiotic supplement is recommended for burns patients.https://ijm.tums.ac.ir/index.php/ijm/article/view/2074ProbioticMicrobiomeBacterial translocationLactobacillusBifidobacterium |
| spellingShingle | David S. Perdanakusuma Lynda Hariani Nur Febriany Nasser Robertus Arian Datusanantyo The effect of a single-strain probiotic administration in the treatment of thermal burns patients Iranian Journal of Microbiology Probiotic Microbiome Bacterial translocation Lactobacillus Bifidobacterium |
| title | The effect of a single-strain probiotic administration in the treatment of thermal burns patients |
| title_full | The effect of a single-strain probiotic administration in the treatment of thermal burns patients |
| title_fullStr | The effect of a single-strain probiotic administration in the treatment of thermal burns patients |
| title_full_unstemmed | The effect of a single-strain probiotic administration in the treatment of thermal burns patients |
| title_short | The effect of a single-strain probiotic administration in the treatment of thermal burns patients |
| title_sort | effect of a single strain probiotic administration in the treatment of thermal burns patients |
| topic | Probiotic Microbiome Bacterial translocation Lactobacillus Bifidobacterium |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/2074 |
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