Value of apparent diffusion coefficient factor in correlation with the molecular subtypes, tumor grade, and expression of Ki-67 in breast cancer
Abstract Background Breast cancer is known to be the most common cancer in women; in the last decade, contrast-enhanced magnetic resonance imaging has become an important tool in the diagnosis of cancer breast. Numerous studies have analyzed associations between imaging and histopathological feature...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2022-09-01
|
| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-022-00881-2 |
| _version_ | 1811274894022803456 |
|---|---|
| author | Rania Hegazy Heba Azzam |
| author_facet | Rania Hegazy Heba Azzam |
| author_sort | Rania Hegazy |
| collection | DOAJ |
| description | Abstract Background Breast cancer is known to be the most common cancer in women; in the last decade, contrast-enhanced magnetic resonance imaging has become an important tool in the diagnosis of cancer breast. Numerous studies have analyzed associations between imaging and histopathological features as well as the proliferation potential of breast cancer. The purpose of this study was to evaluate the relationship between the apparent diffusion coefficient (ADC) and expression of Ki-67 as well as tumor molecular subtype in breast cancer. Results No significant difference between the mean ADC value of tumors of grade I, II, and III was found. However, there was a significant difference between the mean ADC value of tumors of molecular type A and molecular type B (P = 0.000), HER2 overexpression (P = 0.018), and TN (P = 0.000), respectively. However, there was no significant difference between molecular type B, HER2 overexpression and TN. Also, no significant difference was found between the Ki-67 value of tumors of grade I, II, and III. Yet there was a significant difference between the mean ADC value of tumors of molecular type A and molecular type B (P = 0.000), HER2 overexpression (P = 0.014), and TN (P = 0.000), respectively. However, there was no significant difference between molecular type B, HER2 overexpression, and TN. Conclusions There is a significant inverse correlation between ADC values and Ki-67 expression. DWI and Ki-67 could be a good discriminator between tumors of molecular subtype A from other subtypes, yet it did not show a correlation with the tumor grade. |
| first_indexed | 2024-04-12T23:27:09Z |
| format | Article |
| id | doaj.art-94025114ccbe4b29a78901a83434291f |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-04-12T23:27:09Z |
| publishDate | 2022-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-94025114ccbe4b29a78901a83434291f2022-12-22T03:12:22ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622022-09-015311910.1186/s43055-022-00881-2Value of apparent diffusion coefficient factor in correlation with the molecular subtypes, tumor grade, and expression of Ki-67 in breast cancerRania Hegazy0Heba Azzam1Clinical and Interventional Radiology Department, Faculty of Medicine, Cairo UniversityClinical and Interventional Radiology Department, Faculty of Medicine, Cairo UniversityAbstract Background Breast cancer is known to be the most common cancer in women; in the last decade, contrast-enhanced magnetic resonance imaging has become an important tool in the diagnosis of cancer breast. Numerous studies have analyzed associations between imaging and histopathological features as well as the proliferation potential of breast cancer. The purpose of this study was to evaluate the relationship between the apparent diffusion coefficient (ADC) and expression of Ki-67 as well as tumor molecular subtype in breast cancer. Results No significant difference between the mean ADC value of tumors of grade I, II, and III was found. However, there was a significant difference between the mean ADC value of tumors of molecular type A and molecular type B (P = 0.000), HER2 overexpression (P = 0.018), and TN (P = 0.000), respectively. However, there was no significant difference between molecular type B, HER2 overexpression and TN. Also, no significant difference was found between the Ki-67 value of tumors of grade I, II, and III. Yet there was a significant difference between the mean ADC value of tumors of molecular type A and molecular type B (P = 0.000), HER2 overexpression (P = 0.014), and TN (P = 0.000), respectively. However, there was no significant difference between molecular type B, HER2 overexpression, and TN. Conclusions There is a significant inverse correlation between ADC values and Ki-67 expression. DWI and Ki-67 could be a good discriminator between tumors of molecular subtype A from other subtypes, yet it did not show a correlation with the tumor grade.https://doi.org/10.1186/s43055-022-00881-2Magnetic resonance imagingDiffusionADC valueKi-67Breast cancer molecular subtypes |
| spellingShingle | Rania Hegazy Heba Azzam Value of apparent diffusion coefficient factor in correlation with the molecular subtypes, tumor grade, and expression of Ki-67 in breast cancer The Egyptian Journal of Radiology and Nuclear Medicine Magnetic resonance imaging Diffusion ADC value Ki-67 Breast cancer molecular subtypes |
| title | Value of apparent diffusion coefficient factor in correlation with the molecular subtypes, tumor grade, and expression of Ki-67 in breast cancer |
| title_full | Value of apparent diffusion coefficient factor in correlation with the molecular subtypes, tumor grade, and expression of Ki-67 in breast cancer |
| title_fullStr | Value of apparent diffusion coefficient factor in correlation with the molecular subtypes, tumor grade, and expression of Ki-67 in breast cancer |
| title_full_unstemmed | Value of apparent diffusion coefficient factor in correlation with the molecular subtypes, tumor grade, and expression of Ki-67 in breast cancer |
| title_short | Value of apparent diffusion coefficient factor in correlation with the molecular subtypes, tumor grade, and expression of Ki-67 in breast cancer |
| title_sort | value of apparent diffusion coefficient factor in correlation with the molecular subtypes tumor grade and expression of ki 67 in breast cancer |
| topic | Magnetic resonance imaging Diffusion ADC value Ki-67 Breast cancer molecular subtypes |
| url | https://doi.org/10.1186/s43055-022-00881-2 |
| work_keys_str_mv | AT raniahegazy valueofapparentdiffusioncoefficientfactorincorrelationwiththemolecularsubtypestumorgradeandexpressionofki67inbreastcancer AT hebaazzam valueofapparentdiffusioncoefficientfactorincorrelationwiththemolecularsubtypestumorgradeandexpressionofki67inbreastcancer |