Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma.

Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma.

Accumulating evidence(s) indicate that CXCL12-CXCR4 signaling cascade plays an important role in the process of invasion and metastasis that accounts for more than 80% of deaths in hepatocellular carcinoma (HCC) patients. Thus, identification of novel agents that can downregulate CXCR4 expression an...

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Bibliographic Details
Main Authors: Kanjoormana Aryan Manu, Muthu K Shanmugam, Tina H Ong, Aruljothi Subramaniam, Kodappully Sivaraman Siveen, Ekambaram Perumal, Ramar Perumal Samy, Pradeep Bist, Lina H K Lim, Alan Prem Kumar, Kam M Hui, Gautam Sethi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3589458?pdf=render

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