Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal
Abstract Pharmaceutical quality control products (QC) demand quick, sensitive, and cost-effective methods to ensure high production at a low cost. Green analytical methods are also becoming more common in pharmaceutical research to cut down on the amount of waste that goes into the environment. Mecl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13065-022-00860-8 |
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| author | Hany Ibrahim Omar M El-Abassy Hisham Ezzat Abdellatef Hassan A. M. Hendawy Heba M El-Sayed |
| author_facet | Hany Ibrahim Omar M El-Abassy Hisham Ezzat Abdellatef Hassan A. M. Hendawy Heba M El-Sayed |
| author_sort | Hany Ibrahim |
| collection | DOAJ |
| description | Abstract Pharmaceutical quality control products (QC) demand quick, sensitive, and cost-effective methods to ensure high production at a low cost. Green analytical methods are also becoming more common in pharmaceutical research to cut down on the amount of waste that goes into the environment. Meclizine hydrochloride (MZH) and pyridoxine hydrochloride (PYH) are reported to be excellent for calming down COVID-19. As a result, the amount of MZH and PYH manufactured by multinational pharmaceutical organizations has increased considerably during the last several months. The present work proposes three environmentally friendly, straightforward, and sensitive spectrophotometric procedures for quantification of MZH in the presence of PYH in a pure and marketable formulations. The approaches under examination include ratio subtraction (RSM), induced dual wavelength (IDW), and Fourier self-deconvolution (FSD). PYH, on the other hand, was directly quantified at 290 nm. For both drugs, the procedures follow Beer’s law in the range of (5–50 µg/mL). The RSM, IDW, and FSD methods, as well as the zero-order approach for PYH, have all been verified in accordance with ICH standards. The ecological value of established methodologies was determined using four distinct ways: the national environmental methods index (NEMI), the analytical Eco-scale, the Analytical Greenness Metric (AGREE), and the green analytical process index (GAPI). Comparing the findings to those of the previously described spectrophotometric technique, no major changes were identified. |
| first_indexed | 2024-04-12T02:40:57Z |
| format | Article |
| id | doaj.art-94079e5a6d6441dc94464d0472329805 |
| institution | Directory Open Access Journal |
| issn | 2661-801X |
| language | English |
| last_indexed | 2024-04-12T02:40:57Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Chemistry |
| spelling | doaj.art-94079e5a6d6441dc94464d04723298052022-12-22T03:51:19ZengBMCBMC Chemistry2661-801X2022-09-0116111510.1186/s13065-022-00860-8Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisalHany Ibrahim0Omar M El-Abassy1Hisham Ezzat Abdellatef2Hassan A. M. Hendawy3Heba M El-Sayed4Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian UniversityPharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian UniversityDepartment of Analytical Chemistry, Faculty of Pharmacy, Zagazig UniversityPharmaceutical Chemistry Department, Egyptian Drug AuthorityDepartment of Analytical Chemistry, Faculty of Pharmacy, Zagazig UniversityAbstract Pharmaceutical quality control products (QC) demand quick, sensitive, and cost-effective methods to ensure high production at a low cost. Green analytical methods are also becoming more common in pharmaceutical research to cut down on the amount of waste that goes into the environment. Meclizine hydrochloride (MZH) and pyridoxine hydrochloride (PYH) are reported to be excellent for calming down COVID-19. As a result, the amount of MZH and PYH manufactured by multinational pharmaceutical organizations has increased considerably during the last several months. The present work proposes three environmentally friendly, straightforward, and sensitive spectrophotometric procedures for quantification of MZH in the presence of PYH in a pure and marketable formulations. The approaches under examination include ratio subtraction (RSM), induced dual wavelength (IDW), and Fourier self-deconvolution (FSD). PYH, on the other hand, was directly quantified at 290 nm. For both drugs, the procedures follow Beer’s law in the range of (5–50 µg/mL). The RSM, IDW, and FSD methods, as well as the zero-order approach for PYH, have all been verified in accordance with ICH standards. The ecological value of established methodologies was determined using four distinct ways: the national environmental methods index (NEMI), the analytical Eco-scale, the Analytical Greenness Metric (AGREE), and the green analytical process index (GAPI). Comparing the findings to those of the previously described spectrophotometric technique, no major changes were identified.https://doi.org/10.1186/s13065-022-00860-8COVID-19Ratio subtractionInduced dual wavelengthFourier self-deconvolutionEcological appraisal |
| spellingShingle | Hany Ibrahim Omar M El-Abassy Hisham Ezzat Abdellatef Hassan A. M. Hendawy Heba M El-Sayed Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal BMC Chemistry COVID-19 Ratio subtraction Induced dual wavelength Fourier self-deconvolution Ecological appraisal |
| title | Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal |
| title_full | Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal |
| title_fullStr | Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal |
| title_full_unstemmed | Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal |
| title_short | Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal |
| title_sort | simultaneous analysis of two drugs used as supportive treatment for covid 19 comparative statistical studies and analytical ecological appraisal |
| topic | COVID-19 Ratio subtraction Induced dual wavelength Fourier self-deconvolution Ecological appraisal |
| url | https://doi.org/10.1186/s13065-022-00860-8 |
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