All-Polymeric Electrode Based on PEDOT:PSS for In Vivo Neural Recording
One of the significant challenges today in the brain–machine interfaces that use invasive methods is the stability of the chronic record. In recent years, polymer-based electrodes have gained notoriety for achieving mechanical strength values close to that of brain tissue, promoting a lower immune r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/10/853 |
| _version_ | 1827651321945128960 |
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| author | Gilberto Filho Cláudio Júnior Bruno Spinelli Igor Damasceno Felipe Fiuza Edgard Morya |
| author_facet | Gilberto Filho Cláudio Júnior Bruno Spinelli Igor Damasceno Felipe Fiuza Edgard Morya |
| author_sort | Gilberto Filho |
| collection | DOAJ |
| description | One of the significant challenges today in the brain–machine interfaces that use invasive methods is the stability of the chronic record. In recent years, polymer-based electrodes have gained notoriety for achieving mechanical strength values close to that of brain tissue, promoting a lower immune response to the implant. In this work, we fabricated fully polymeric electrodes based on PEDOT:PSS for neural recording in Wistar rats. We characterized the electrical properties and both in vitro and in vivo functionality of the electrodes. Additionally, we employed histological processing and microscopical visualization to evaluate the tecidual immune response at 7, 14, and 21 days post-implant. Electrodes with 400-micrometer channels showed a 12 dB signal-to-noise ratio. Local field potentials were characterized under two conditions: anesthetized and free-moving. There was a proliferation of microglia at the tissue–electrode interface in the early days, though there was a decrease after 14 days. Astrocytes also migrated to the interface, but there was not continuous recruitment of these cells in the tissue; there was inflammatory stability by day 21. The signal was not affected by this inflammatory action, demonstrating that fully polymeric electrodes can be an alternative means to prolong the valuable time of neural recordings. |
| first_indexed | 2024-03-09T20:36:07Z |
| format | Article |
| id | doaj.art-9407f268130a4de1890903e1a8ef840e |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T20:36:07Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-9407f268130a4de1890903e1a8ef840e2023-11-23T23:11:43ZengMDPI AGBiosensors2079-63742022-10-01121085310.3390/bios12100853All-Polymeric Electrode Based on PEDOT:PSS for In Vivo Neural RecordingGilberto Filho0Cláudio Júnior1Bruno Spinelli2Igor Damasceno3Felipe Fiuza4Edgard Morya5Edmond and Lily Safra International Institute of Neuroscience (ELS-IIN), Macaíba 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience (ELS-IIN), Macaíba 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience (ELS-IIN), Macaíba 59280-000, BrazilDepartment of Materials Engineering, Federal University of Rio Grande do Norte (UFRN), Natal 59072-970, BrazilEdmond and Lily Safra International Institute of Neuroscience (ELS-IIN), Macaíba 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience (ELS-IIN), Macaíba 59280-000, BrazilOne of the significant challenges today in the brain–machine interfaces that use invasive methods is the stability of the chronic record. In recent years, polymer-based electrodes have gained notoriety for achieving mechanical strength values close to that of brain tissue, promoting a lower immune response to the implant. In this work, we fabricated fully polymeric electrodes based on PEDOT:PSS for neural recording in Wistar rats. We characterized the electrical properties and both in vitro and in vivo functionality of the electrodes. Additionally, we employed histological processing and microscopical visualization to evaluate the tecidual immune response at 7, 14, and 21 days post-implant. Electrodes with 400-micrometer channels showed a 12 dB signal-to-noise ratio. Local field potentials were characterized under two conditions: anesthetized and free-moving. There was a proliferation of microglia at the tissue–electrode interface in the early days, though there was a decrease after 14 days. Astrocytes also migrated to the interface, but there was not continuous recruitment of these cells in the tissue; there was inflammatory stability by day 21. The signal was not affected by this inflammatory action, demonstrating that fully polymeric electrodes can be an alternative means to prolong the valuable time of neural recordings.https://www.mdpi.com/2079-6374/12/10/853PEDOT:PSSneural recordingimmune responseBMI |
| spellingShingle | Gilberto Filho Cláudio Júnior Bruno Spinelli Igor Damasceno Felipe Fiuza Edgard Morya All-Polymeric Electrode Based on PEDOT:PSS for In Vivo Neural Recording Biosensors PEDOT:PSS neural recording immune response BMI |
| title | All-Polymeric Electrode Based on PEDOT:PSS for In Vivo Neural Recording |
| title_full | All-Polymeric Electrode Based on PEDOT:PSS for In Vivo Neural Recording |
| title_fullStr | All-Polymeric Electrode Based on PEDOT:PSS for In Vivo Neural Recording |
| title_full_unstemmed | All-Polymeric Electrode Based on PEDOT:PSS for In Vivo Neural Recording |
| title_short | All-Polymeric Electrode Based on PEDOT:PSS for In Vivo Neural Recording |
| title_sort | all polymeric electrode based on pedot pss for in vivo neural recording |
| topic | PEDOT:PSS neural recording immune response BMI |
| url | https://www.mdpi.com/2079-6374/12/10/853 |
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