Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patients
Abstract Background The occurrence of Chemotherapy-induced neutropenia (CIN) was reported to be a predictor of better survival in several cancers. The objective of our study is to evaluate the relationship between the timing of CIN and prognosis. Methods Between June 2012 and August 2014, 290 patien...
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| Format: | Article |
| Language: | English |
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BMC
2017-04-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3240-6 |
| _version_ | 1811226817368948736 |
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| author | Yang Chen YanRong Wang Yan Shi GuangHai Dai |
| author_facet | Yang Chen YanRong Wang Yan Shi GuangHai Dai |
| author_sort | Yang Chen |
| collection | DOAJ |
| description | Abstract Background The occurrence of Chemotherapy-induced neutropenia (CIN) was reported to be a predictor of better survival in several cancers. The objective of our study is to evaluate the relationship between the timing of CIN and prognosis. Methods Between June 2012 and August 2014, 290 patients with confirmed metastatic colon cancer received at least one cycle of mFOLFOX6 as first-line chemotherapy were eligible for assessment as all patients group. Of the 232 received at least six cycles of mFOLFOX6 and survived 150 days after treatment were considered as landmark group. Timing of CIN was categorized into absence, early-onset and late-onset CIN groups. The end of cycle 3 was the cutoff to differentiate early-onset or late-onset. The correlation between timing of CIN with survival was analyzed by Kaplan-Meier method and Cox proportional hazards model. Results In all patients group, the median survival of patients without neutropenia, early-onset and late-onset neutropenia were 6.7, 20.7 and 12.8 months (P < 0.001). The patients with early-onset and late-onset CIN had better prognosis than CIN absence by multivariate analysis. Findings were much the same for landmark group. Conclusions In conclusion, timing of CIN is an independent predictor of prognosis in metastatic colon cancer patients received mFOLFOX6, whereas an early-onset of CIN predicts longer survival. |
| first_indexed | 2024-04-12T09:32:40Z |
| format | Article |
| id | doaj.art-940964121aa54757812ef047e7504bed |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T09:32:40Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-940964121aa54757812ef047e7504bed2022-12-22T03:38:20ZengBMCBMC Cancer1471-24072017-04-011711810.1186/s12885-017-3240-6Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patientsYang Chen0YanRong Wang1Yan Shi2GuangHai Dai3Medical Oncology Department 2, Chinese People’s Liberation Army General HospitalMedical Oncology Department 2, Chinese People’s Liberation Army General HospitalMedical Oncology Department 2, Chinese People’s Liberation Army General HospitalMedical Oncology Department 2, Chinese People’s Liberation Army General HospitalAbstract Background The occurrence of Chemotherapy-induced neutropenia (CIN) was reported to be a predictor of better survival in several cancers. The objective of our study is to evaluate the relationship between the timing of CIN and prognosis. Methods Between June 2012 and August 2014, 290 patients with confirmed metastatic colon cancer received at least one cycle of mFOLFOX6 as first-line chemotherapy were eligible for assessment as all patients group. Of the 232 received at least six cycles of mFOLFOX6 and survived 150 days after treatment were considered as landmark group. Timing of CIN was categorized into absence, early-onset and late-onset CIN groups. The end of cycle 3 was the cutoff to differentiate early-onset or late-onset. The correlation between timing of CIN with survival was analyzed by Kaplan-Meier method and Cox proportional hazards model. Results In all patients group, the median survival of patients without neutropenia, early-onset and late-onset neutropenia were 6.7, 20.7 and 12.8 months (P < 0.001). The patients with early-onset and late-onset CIN had better prognosis than CIN absence by multivariate analysis. Findings were much the same for landmark group. Conclusions In conclusion, timing of CIN is an independent predictor of prognosis in metastatic colon cancer patients received mFOLFOX6, whereas an early-onset of CIN predicts longer survival.http://link.springer.com/article/10.1186/s12885-017-3240-6Metastatic colon cancerTiming of chemotherapy-induced neutropenia (CIN)PrognosisChemotherapy |
| spellingShingle | Yang Chen YanRong Wang Yan Shi GuangHai Dai Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patients BMC Cancer Metastatic colon cancer Timing of chemotherapy-induced neutropenia (CIN) Prognosis Chemotherapy |
| title | Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patients |
| title_full | Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patients |
| title_fullStr | Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patients |
| title_full_unstemmed | Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patients |
| title_short | Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patients |
| title_sort | timing of chemotherapy induced neutropenia predicts prognosis in metastatic colon cancer patients a retrospective study in mfolfox6 treated patients |
| topic | Metastatic colon cancer Timing of chemotherapy-induced neutropenia (CIN) Prognosis Chemotherapy |
| url | http://link.springer.com/article/10.1186/s12885-017-3240-6 |
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