Effect of Hydroxyethyl Starch on Blood Sugar Levels in Surgeries under Subarachnoid Block: A Cross-sectional Study
Introduction: Ringer’s Lactate (RL), a crystalloid is the most common co-loading fluid used to limit haemodynamic complications following the Subarachnoid Block (SAB). Colloids like Hydroxyethyl Starches (HES) are occasionally used as the co-loading fluid despite controversies due to its better...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2020-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/14102/45274_CE[Ra1]_F(KM)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
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| author | Abraham Lalchhana Chawnchhim Mathews Jacob Alok Jaiswal Debashish Paul Kaminder Bir Kaur Arijit Ray Shalendra Singh |
| author_facet | Abraham Lalchhana Chawnchhim Mathews Jacob Alok Jaiswal Debashish Paul Kaminder Bir Kaur Arijit Ray Shalendra Singh |
| author_sort | Abraham Lalchhana Chawnchhim |
| collection | DOAJ |
| description | Introduction: Ringer’s Lactate (RL), a crystalloid is the
most common co-loading fluid used to limit haemodynamic
complications following the Subarachnoid Block (SAB).
Colloids like Hydroxyethyl Starches (HES) are occasionally
used as the co-loading fluid despite controversies due to its
better haemodynamic effect and are not written-off to date.
So knowledge of the effect of co-loading fluid is of paramount
importance if it contributes to hyperglycaemia, a detrimental
factor for the outcome.
Aim: To compare the Blood Sugar Levels (BSL) in different
preparations of HES and to that of RL when administered as
co-loading fluid following SAB.
Materials and Methods: Eighty-nine patients were randomly
allocated into three groups, namely HES 200, HES 130, and RL,
and were co-loaded with either 20 mL/kg body weight of HES
200/0.5, 20 mL/kg body weight of HES 130/0.4 or 20 mL/kg body
weight of RL respectively. BSL for each subject was recorded at
0, 15, 30, 45, 60, 120, 180, 240 min (post-hoc analysis was done
with Tukey’s test).
Results: In all the three groups, there was a statistically
significant rise in BSL from baseline. The BSL in the RL group
reached its peak at 45 minutes and gradually dropped down
to baseline. BSL increased more gradually with HES 130/0.4
reaching a peak value at 60 minutes, and at around 240 minutes
for HES 200/0.5.
Conclusion: HES causes an increase in BSL, though within
physiological limits. |
| first_indexed | 2024-12-17T22:54:57Z |
| format | Article |
| id | doaj.art-940a37cea0684e8f84eea14626b79cb4 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-17T22:54:57Z |
| publishDate | 2020-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-940a37cea0684e8f84eea14626b79cb42022-12-21T21:29:34ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-10-011410UC11UC1410.7860/JCDR/2020/45274.14102Effect of Hydroxyethyl Starch on Blood Sugar Levels in Surgeries under Subarachnoid Block: A Cross-sectional StudyAbraham Lalchhana Chawnchhim0Mathews Jacob1Alok Jaiswal2Debashish Paul3Kaminder Bir Kaur4Arijit Ray5Shalendra Singh6Senior Resident, Department of Neuroanaesthesiology, AIIMS, New Delhi, India.Professor, Department of Anaesthesiology, AICTS and AFMC, Pune, Maharashtra, India.Assistant Professor, Department of Anaesthesiology, AFMC, Pune, Maharashtra, India.Assistant Professor, Department of Anaesthesiology, AFMC, Pune, Maharashtra, India.Senior Resident, Department of Anaesthesiology, AFMC, Pune, Maharashtra, India.Assistant Professor, Department of Anaesthesiology, INHS Asvini, Mumbai, Maharashtra, India.Associate Professor, Department of Anaesthesiology, AFMC, Pune, Maharashtra, India.Introduction: Ringer’s Lactate (RL), a crystalloid is the most common co-loading fluid used to limit haemodynamic complications following the Subarachnoid Block (SAB). Colloids like Hydroxyethyl Starches (HES) are occasionally used as the co-loading fluid despite controversies due to its better haemodynamic effect and are not written-off to date. So knowledge of the effect of co-loading fluid is of paramount importance if it contributes to hyperglycaemia, a detrimental factor for the outcome. Aim: To compare the Blood Sugar Levels (BSL) in different preparations of HES and to that of RL when administered as co-loading fluid following SAB. Materials and Methods: Eighty-nine patients were randomly allocated into three groups, namely HES 200, HES 130, and RL, and were co-loaded with either 20 mL/kg body weight of HES 200/0.5, 20 mL/kg body weight of HES 130/0.4 or 20 mL/kg body weight of RL respectively. BSL for each subject was recorded at 0, 15, 30, 45, 60, 120, 180, 240 min (post-hoc analysis was done with Tukey’s test). Results: In all the three groups, there was a statistically significant rise in BSL from baseline. The BSL in the RL group reached its peak at 45 minutes and gradually dropped down to baseline. BSL increased more gradually with HES 130/0.4 reaching a peak value at 60 minutes, and at around 240 minutes for HES 200/0.5. Conclusion: HES causes an increase in BSL, though within physiological limits.https://jcdr.net/articles/PDF/14102/45274_CE[Ra1]_F(KM)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdfcolloidshyperglycaemiaspinal anaesthesia |
| spellingShingle | Abraham Lalchhana Chawnchhim Mathews Jacob Alok Jaiswal Debashish Paul Kaminder Bir Kaur Arijit Ray Shalendra Singh Effect of Hydroxyethyl Starch on Blood Sugar Levels in Surgeries under Subarachnoid Block: A Cross-sectional Study Journal of Clinical and Diagnostic Research colloids hyperglycaemia spinal anaesthesia |
| title | Effect of Hydroxyethyl Starch on Blood Sugar Levels in Surgeries under Subarachnoid Block: A Cross-sectional Study |
| title_full | Effect of Hydroxyethyl Starch on Blood Sugar Levels in Surgeries under Subarachnoid Block: A Cross-sectional Study |
| title_fullStr | Effect of Hydroxyethyl Starch on Blood Sugar Levels in Surgeries under Subarachnoid Block: A Cross-sectional Study |
| title_full_unstemmed | Effect of Hydroxyethyl Starch on Blood Sugar Levels in Surgeries under Subarachnoid Block: A Cross-sectional Study |
| title_short | Effect of Hydroxyethyl Starch on Blood Sugar Levels in Surgeries under Subarachnoid Block: A Cross-sectional Study |
| title_sort | effect of hydroxyethyl starch on blood sugar levels in surgeries under subarachnoid block a cross sectional study |
| topic | colloids hyperglycaemia spinal anaesthesia |
| url | https://jcdr.net/articles/PDF/14102/45274_CE[Ra1]_F(KM)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
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