The Role of Smoothened in Cancer
Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PT...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/18/6863 |
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| author | Kuo-Shyang Jeng I-Shyan Sheen Chuen-Miin Leu Ping-Hui Tseng Chiung-Fang Chang |
| author_facet | Kuo-Shyang Jeng I-Shyan Sheen Chuen-Miin Leu Ping-Hui Tseng Chiung-Fang Chang |
| author_sort | Kuo-Shyang Jeng |
| collection | DOAJ |
| description | Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. SMO expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity. A better understanding of the role of SMO in cancer could contribute to the development of novel therapeutic approaches. |
| first_indexed | 2024-03-10T16:13:44Z |
| format | Article |
| id | doaj.art-940b927de1cc4f60bca4eeb00df07eec |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:13:44Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-940b927de1cc4f60bca4eeb00df07eec2023-11-20T14:17:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012118686310.3390/ijms21186863The Role of Smoothened in CancerKuo-Shyang Jeng0I-Shyan Sheen1Chuen-Miin Leu2Ping-Hui Tseng3Chiung-Fang Chang4Division of General Surgery, Far Eastern Memorial Hospital, New Taipei City 22060, TaiwanDepartment of Hepato-Gastroenterology, Chang-Gung Memorial Hospital, Linkou Medical Center, Chang-Gung University, Taoyuan City 33305, TaiwanInstitute of Microbiology and Immunology, National Yang-Ming University, Taipei City 11221, TaiwanInstitute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei City 11221, TaiwanDivision of General Surgery, Far Eastern Memorial Hospital, New Taipei City 22060, TaiwanSmoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. SMO expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity. A better understanding of the role of SMO in cancer could contribute to the development of novel therapeutic approaches.https://www.mdpi.com/1422-0067/21/18/6863SmoothenedHedgehog signaling pathwaycancer stem cells |
| spellingShingle | Kuo-Shyang Jeng I-Shyan Sheen Chuen-Miin Leu Ping-Hui Tseng Chiung-Fang Chang The Role of Smoothened in Cancer International Journal of Molecular Sciences Smoothened Hedgehog signaling pathway cancer stem cells |
| title | The Role of Smoothened in Cancer |
| title_full | The Role of Smoothened in Cancer |
| title_fullStr | The Role of Smoothened in Cancer |
| title_full_unstemmed | The Role of Smoothened in Cancer |
| title_short | The Role of Smoothened in Cancer |
| title_sort | role of smoothened in cancer |
| topic | Smoothened Hedgehog signaling pathway cancer stem cells |
| url | https://www.mdpi.com/1422-0067/21/18/6863 |
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