TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors

TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors

Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, “silent” nociceptors and might be due to high expression of NaV1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX-r). Nociceptor-class specific differences in action p...

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Bibliographic Details
Main Authors: Robin Jonas, Vincenzo Prato, Stefan G. Lechner, Gerbrand Groen, Otilia Obreja, Fiona Werland, Roman Rukwied, Andreas Klusch, Marlen Petersen, Richard W. Carr, Martin Schmelz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
tetrodotoxin
activity-dependent slowing of conduction
axonal calcium imaging
action potential conduction
nociceptor classes
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00013/full

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