DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells

DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells

Benzo[a]pyrene (B[a]P) is a class I carcinogen and hazardous environmental pollutant with genetic toxicity. Understanding the molecular mechanisms underlying genetic deterioration and epigenetic alterations induced by environmental contaminants may contribute to the early detection and prevention of...

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Bibliographic Details
Main Authors: Miaoyun Qiu, Nan Zhang, Shuwei Yao, Hanyu Zhou, Xintong Chen, Yangyang Jia, Han Zhang, Xin Li, Yiguo Jiang
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Environment International
Subjects:
B[a]P
DNA damage
circRNA
NONO-SFPQ complex
DNMT3A
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412022005542

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