Ex-chitin-g news on drug-induced fungal epitope unmasking
ABSTRACT The microbial cell wall is an essential cellular organelle commonly targeted by antimicrobials. It is also a battleground of innate immune recognition where microbes can evade immune recognition by masking essential cell wall components. A recent study (A. S. Wagner, S. W. Lumsdaine, M. M....
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2023-10-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.01387-23 |
| _version_ | 1797619701040283648 |
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| author | Robert T. Wheeler |
| author_facet | Robert T. Wheeler |
| author_sort | Robert T. Wheeler |
| collection | DOAJ |
| description | ABSTRACT The microbial cell wall is an essential cellular organelle commonly targeted by antimicrobials. It is also a battleground of innate immune recognition where microbes can evade immune recognition by masking essential cell wall components. A recent study (A. S. Wagner, S. W. Lumsdaine, M. M. Mangrum, and T. B. Reynolds, mBio https://doi.org/10.1128/mbio.00074-23, 2023) provides insight into how echinocandin antifungals cause exposure of proinflammatory β(1,3)-glucan by driving excess chitin production in the weakened cell wall. Although many environmental and biological activities perturb cell wall integrity and regulate β(1,3)-glucan exposure, we still know little about which intracellular signaling components regulate the cell wall changes that result in disrupted cell wall architecture. Wagner et al. showed that calcineurin and the Mkc1p kinase regulate chitin deposition and β(1,3)-glucan unmasking. They further identified chitin synthesis as a key driving force in cell wall structure disruption leading to epitope exposure. Their findings highlight how fungal cell wall dynamics have important implications for antifungal immunity and future drug development. |
| first_indexed | 2024-03-11T08:30:34Z |
| format | Article |
| id | doaj.art-940eef4006dd4a3a9839414a15a43e59 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-03-11T08:30:34Z |
| publishDate | 2023-10-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-940eef4006dd4a3a9839414a15a43e592023-11-16T21:48:00ZengAmerican Society for MicrobiologymBio2150-75112023-10-0114510.1128/mbio.01387-23Ex-chitin-g news on drug-induced fungal epitope unmaskingRobert T. Wheeler0Department of Molecular and Biomedical Sciences, University of Maine , Orono, Maine, USAABSTRACT The microbial cell wall is an essential cellular organelle commonly targeted by antimicrobials. It is also a battleground of innate immune recognition where microbes can evade immune recognition by masking essential cell wall components. A recent study (A. S. Wagner, S. W. Lumsdaine, M. M. Mangrum, and T. B. Reynolds, mBio https://doi.org/10.1128/mbio.00074-23, 2023) provides insight into how echinocandin antifungals cause exposure of proinflammatory β(1,3)-glucan by driving excess chitin production in the weakened cell wall. Although many environmental and biological activities perturb cell wall integrity and regulate β(1,3)-glucan exposure, we still know little about which intracellular signaling components regulate the cell wall changes that result in disrupted cell wall architecture. Wagner et al. showed that calcineurin and the Mkc1p kinase regulate chitin deposition and β(1,3)-glucan unmasking. They further identified chitin synthesis as a key driving force in cell wall structure disruption leading to epitope exposure. Their findings highlight how fungal cell wall dynamics have important implications for antifungal immunity and future drug development.https://journals.asm.org/doi/10.1128/mbio.01387-23Candidaantifungal agentscell wallchitincalcineurinmitogen-activated protein kinases |
| spellingShingle | Robert T. Wheeler Ex-chitin-g news on drug-induced fungal epitope unmasking mBio Candida antifungal agents cell wall chitin calcineurin mitogen-activated protein kinases |
| title | Ex-chitin-g news on drug-induced fungal epitope unmasking |
| title_full | Ex-chitin-g news on drug-induced fungal epitope unmasking |
| title_fullStr | Ex-chitin-g news on drug-induced fungal epitope unmasking |
| title_full_unstemmed | Ex-chitin-g news on drug-induced fungal epitope unmasking |
| title_short | Ex-chitin-g news on drug-induced fungal epitope unmasking |
| title_sort | ex chitin g news on drug induced fungal epitope unmasking |
| topic | Candida antifungal agents cell wall chitin calcineurin mitogen-activated protein kinases |
| url | https://journals.asm.org/doi/10.1128/mbio.01387-23 |
| work_keys_str_mv | AT roberttwheeler exchitingnewsondruginducedfungalepitopeunmasking |