Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer
<p><b>Objective:</b> To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET).</p><p><b>Methods:</b> A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ g...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ivyspring International Publisher
2012-01-01
|
| Series: | International Journal of Medical Sciences |
| Online Access: | http://www.medsci.org/v09p0121.htm |
| _version_ | 1811272887410098176 |
|---|---|
| author | Yi-ping Zhong, Ying Ying, Hai-tao Wu, Can-quan Zhou, Yan-wen Xu, Qiong Wang, Jie Li, Xiao-ting Shen, Jin Li |
| author_facet | Yi-ping Zhong, Ying Ying, Hai-tao Wu, Can-quan Zhou, Yan-wen Xu, Qiong Wang, Jie Li, Xiao-ting Shen, Jin Li |
| author_sort | Yi-ping Zhong, Ying Ying, Hai-tao Wu, Can-quan Zhou, Yan-wen Xu, Qiong Wang, Jie Li, Xiao-ting Shen, Jin Li |
| collection | DOAJ |
| description | <p><b>Objective:</b> To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET).</p><p><b>Methods:</b> A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ group) and 676 infertile women (1062 cycles) negative for antithyroid antibody (ATA- group) undergoing IVF/ICSI from August 2009 to August 2010 were retrospectively analyzed.</p><p><b>Results:</b> There was no significant difference in the days of ovarian stimulation, total gonadotropin dose, serum E2 level of HCG day and number of oocytes retrieved between the two groups. The fertilization rate, implantation rate and pregnancy rate following IVF-ET were significantly lower in women with antithyroid antibody than in control group (64.3% vs 74.6%, 17.8% vs 27.1% and 33.3% vs 46.7%, respectively), but the abortion rate was significantly higher in patients with antithyroid antibody (26.9% vs 11.8%).</p><p><b>Conclusion: </b>Patients with antithyroid antibody showed significantly lower fertilization rate, implantation rate and pregnancy rate and higher risk for abortion following IVF-ET when compared with those without antithyroid antibody. Thus, the presence of antithyroid antibody is detrimental for the pregnancy outcome following IVF-ET.</p> |
| first_indexed | 2024-04-12T22:49:24Z |
| format | Article |
| id | doaj.art-940f12f7fe8e4f1c81a692984dbf7213 |
| institution | Directory Open Access Journal |
| issn | 1449-1907 |
| language | English |
| last_indexed | 2024-04-12T22:49:24Z |
| publishDate | 2012-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Medical Sciences |
| spelling | doaj.art-940f12f7fe8e4f1c81a692984dbf72132022-12-22T03:13:26ZengIvyspring International PublisherInternational Journal of Medical Sciences1449-19072012-01-0192121125Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo TransferYi-ping Zhong, Ying Ying, Hai-tao Wu, Can-quan Zhou, Yan-wen Xu, Qiong Wang, Jie Li, Xiao-ting Shen, Jin Li<p><b>Objective:</b> To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET).</p><p><b>Methods:</b> A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ group) and 676 infertile women (1062 cycles) negative for antithyroid antibody (ATA- group) undergoing IVF/ICSI from August 2009 to August 2010 were retrospectively analyzed.</p><p><b>Results:</b> There was no significant difference in the days of ovarian stimulation, total gonadotropin dose, serum E2 level of HCG day and number of oocytes retrieved between the two groups. The fertilization rate, implantation rate and pregnancy rate following IVF-ET were significantly lower in women with antithyroid antibody than in control group (64.3% vs 74.6%, 17.8% vs 27.1% and 33.3% vs 46.7%, respectively), but the abortion rate was significantly higher in patients with antithyroid antibody (26.9% vs 11.8%).</p><p><b>Conclusion: </b>Patients with antithyroid antibody showed significantly lower fertilization rate, implantation rate and pregnancy rate and higher risk for abortion following IVF-ET when compared with those without antithyroid antibody. Thus, the presence of antithyroid antibody is detrimental for the pregnancy outcome following IVF-ET.</p>http://www.medsci.org/v09p0121.htm |
| spellingShingle | Yi-ping Zhong, Ying Ying, Hai-tao Wu, Can-quan Zhou, Yan-wen Xu, Qiong Wang, Jie Li, Xiao-ting Shen, Jin Li Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer International Journal of Medical Sciences |
| title | Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer |
| title_full | Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer |
| title_fullStr | Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer |
| title_full_unstemmed | Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer |
| title_short | Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer |
| title_sort | relationship between antithyroid antibody and pregnancy outcome following in vitro fertilization and embryo transfer |
| url | http://www.medsci.org/v09p0121.htm |
| work_keys_str_mv | AT yipingzhongyingyinghaitaowucanquanzhouyanwenxuqiongwangjielixiaotingshenjinli relationshipbetweenantithyroidantibodyandpregnancyoutcomefollowinginvitrofertilizationandembryotransfer |