Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients
Abstract Despite many diabetic patients having hypercholesterolemia, the association of total cholesterol (TC) levels with CVD risk in type 2 diabetes (T2D) patients is unclear. Diagnosis of type 2 diabetes often leads to changes in total cholesterol (TC) levels. Thus, we examined whether changes in...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33743-6 |
| _version_ | 1827939915572183040 |
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| author | Jaewon Khil Sung Min Kim Jooyoung Chang Seulggie Choi Gyeongsil Lee Joung Sik Son Sang Min Park NaNa Keum |
| author_facet | Jaewon Khil Sung Min Kim Jooyoung Chang Seulggie Choi Gyeongsil Lee Joung Sik Son Sang Min Park NaNa Keum |
| author_sort | Jaewon Khil |
| collection | DOAJ |
| description | Abstract Despite many diabetic patients having hypercholesterolemia, the association of total cholesterol (TC) levels with CVD risk in type 2 diabetes (T2D) patients is unclear. Diagnosis of type 2 diabetes often leads to changes in total cholesterol (TC) levels. Thus, we examined whether changes in TC levels from pre- to post-diagnosis of T2D were associated with CVD risk. From the National Health Insurance Service Cohort, 23,821 individuals diagnosed with T2D from 2003 to 2012 were followed-up for non-fatal CVD incidence through 2015. Two measurements of TC, 2 years before and after T2D diagnosis, were classified into 3 levels (low, middle, high) to define changes in cholesterol levels. Cox proportional hazards regression was performed to estimate adjusted hazards ratios (aHRs) and 95% confidence intervals (CIs) for the associations between changes in cholesterol levels and CVD risk. Subgroup analyses were performed by use of lipid-lowering drugs. Compared with low–low, aHR of CVD was 1.31 [1.10–1.56] for low–middle and 1.80 [1.15–2.83] for low–high. Compared with middle–middle, aHR of CVD was 1.10 [0.92–1.31] for middle–high but 0.83 [0.73–0.94] for middle–low. Compared with high–high, aHR of CVD was 0.68 [0.56–0.83] for high–middle and 0.65 [0.49–0.86] for high–low. The associations were observed regardless of use of lipid-lowering drugs. For diabetic patients, management of TC levels may be important to lower CVD risk. |
| first_indexed | 2024-03-13T09:01:47Z |
| format | Article |
| id | doaj.art-941070eb48444780a21dc272f847b9a7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T09:01:47Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-941070eb48444780a21dc272f847b9a72023-05-28T11:17:24ZengNature PortfolioScientific Reports2045-23222023-05-0113111110.1038/s41598-023-33743-6Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patientsJaewon Khil0Sung Min Kim1Jooyoung Chang2Seulggie Choi3Gyeongsil Lee4Joung Sik Son5Sang Min Park6NaNa Keum7Department of Food Science and Biotechnology, Dongguk University Graduate SchoolDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Internal Medicine, Seoul National University HospitalKS Health Link Inst. and Life ClinicDepartment of Internal Medicine, Hallym University Sacred Heart HospitalDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Food Science and Biotechnology, Dongguk University Graduate SchoolAbstract Despite many diabetic patients having hypercholesterolemia, the association of total cholesterol (TC) levels with CVD risk in type 2 diabetes (T2D) patients is unclear. Diagnosis of type 2 diabetes often leads to changes in total cholesterol (TC) levels. Thus, we examined whether changes in TC levels from pre- to post-diagnosis of T2D were associated with CVD risk. From the National Health Insurance Service Cohort, 23,821 individuals diagnosed with T2D from 2003 to 2012 were followed-up for non-fatal CVD incidence through 2015. Two measurements of TC, 2 years before and after T2D diagnosis, were classified into 3 levels (low, middle, high) to define changes in cholesterol levels. Cox proportional hazards regression was performed to estimate adjusted hazards ratios (aHRs) and 95% confidence intervals (CIs) for the associations between changes in cholesterol levels and CVD risk. Subgroup analyses were performed by use of lipid-lowering drugs. Compared with low–low, aHR of CVD was 1.31 [1.10–1.56] for low–middle and 1.80 [1.15–2.83] for low–high. Compared with middle–middle, aHR of CVD was 1.10 [0.92–1.31] for middle–high but 0.83 [0.73–0.94] for middle–low. Compared with high–high, aHR of CVD was 0.68 [0.56–0.83] for high–middle and 0.65 [0.49–0.86] for high–low. The associations were observed regardless of use of lipid-lowering drugs. For diabetic patients, management of TC levels may be important to lower CVD risk.https://doi.org/10.1038/s41598-023-33743-6 |
| spellingShingle | Jaewon Khil Sung Min Kim Jooyoung Chang Seulggie Choi Gyeongsil Lee Joung Sik Son Sang Min Park NaNa Keum Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients Scientific Reports |
| title | Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients |
| title_full | Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients |
| title_fullStr | Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients |
| title_full_unstemmed | Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients |
| title_short | Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients |
| title_sort | changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients |
| url | https://doi.org/10.1038/s41598-023-33743-6 |
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