SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY
Introduction: The incidence of Squamous cell carcinoma of the skin (SCCs) increases annually, and this process will likely be continued because of sun exposure, outdoor activities and the aging population. Objectives: The aim of our study is to analyse clinicohistopathological features, recurrenc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Peytchinski Publishing
2023-10-01
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| Series: | Journal of IMAB |
| Subjects: | |
| Online Access: | https://www.journal-imab-bg.org/issues-2023/issue4/2023vol29-issue4-5139-5144.pdf |
| _version_ | 1827801515999363072 |
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| author | Preslav Vasilev Savelina Popovska Milen Karaivanov Dobromir Dimitrov Ivelina Yordanova |
| author_facet | Preslav Vasilev Savelina Popovska Milen Karaivanov Dobromir Dimitrov Ivelina Yordanova |
| author_sort | Preslav Vasilev |
| collection | DOAJ |
| description | Introduction: The incidence of Squamous cell carcinoma of the skin (SCCs) increases annually, and this process will likely be continued because of sun exposure, outdoor activities and the aging population.
Objectives: The aim of our study is to analyse clinicohistopathological features, recurrence, metastasis and mortality rates of SCCs in Pleven, Lovech region, Bulgaria.
Methods: We investigated 355 patients with histologically confirmed SCCs for the period 2016 – 2022 and carried out a detailed histopathological analysis of 100 tumors. They were divided into two groups according to their macroscopic diameter: with low risk for recurrence and metastases (<20mm) and high – risk (>20mm). We studied the localisation, histological subtype, tumor cell differentiation, microscopic depth of invasion, perineural and lymphovascular invasion, stromal lymphocyte infiltration.
Results: We revealed that 73,3% of the patients with SCCs reported severe sunburns, and 1,13% of them underwent immunosuppressive treatment. Head and Neck localisation is the most common – 72,7%. We established a mean histological depth of SCCs of 5,92mm, lymphovascular invasion in 7% and perineural invasion in 5% of the cases. We found that tumors with a macroscopic diameter >20mm have a greater depth of invasion in comparison to SCCs with a smaller diameter. We found an incidence of local recurrence of 4,8%, lymph node metastases at 5,1%, far metastases in internal organs at 2,25% and mortality at 1,97%.
Conclusion: Clinicohistopathological features of SCCs with related to recurrence, metastasis and mortality are localisation on the scalp, ears or lips, tumor size >20mm, depth of invasion >6mm, poor tumor cell differentiation, perineural and lymphovascular invasion, low or absent stromal lymphocyte infiltration. |
| first_indexed | 2024-03-11T20:26:27Z |
| format | Article |
| id | doaj.art-9410c8f6a92046c9859863f9736d6fc6 |
| institution | Directory Open Access Journal |
| issn | 1312-773X |
| language | English |
| last_indexed | 2024-03-11T20:26:27Z |
| publishDate | 2023-10-01 |
| publisher | Peytchinski Publishing |
| record_format | Article |
| series | Journal of IMAB |
| spelling | doaj.art-9410c8f6a92046c9859863f9736d6fc62023-10-02T13:59:52ZengPeytchinski PublishingJournal of IMAB1312-773X2023-10-012945139514410.5272/jimab.2023294.5139SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITYPreslav Vasilev0https://orcid.org/0000-0001-6603-4893Savelina Popovska1https://orcid.org/0000-0001-6476-7292Milen Karaivanov2https://orcid.org/0000-0001-7205-3548Dobromir Dimitrov3https://orcid.org/0000-0003-3313-1093Ivelina Yordanova4https://orcid.org/0000-0002-5400-3683Department of Dermatology, Venereology and Allergology, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.Department of General and Clinical Pathology, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.Department of General and Clinical Pathology, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.Surgical Oncology Department, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.Department of Dermatology, Venereology and Allergology, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.Introduction: The incidence of Squamous cell carcinoma of the skin (SCCs) increases annually, and this process will likely be continued because of sun exposure, outdoor activities and the aging population. Objectives: The aim of our study is to analyse clinicohistopathological features, recurrence, metastasis and mortality rates of SCCs in Pleven, Lovech region, Bulgaria. Methods: We investigated 355 patients with histologically confirmed SCCs for the period 2016 – 2022 and carried out a detailed histopathological analysis of 100 tumors. They were divided into two groups according to their macroscopic diameter: with low risk for recurrence and metastases (<20mm) and high – risk (>20mm). We studied the localisation, histological subtype, tumor cell differentiation, microscopic depth of invasion, perineural and lymphovascular invasion, stromal lymphocyte infiltration. Results: We revealed that 73,3% of the patients with SCCs reported severe sunburns, and 1,13% of them underwent immunosuppressive treatment. Head and Neck localisation is the most common – 72,7%. We established a mean histological depth of SCCs of 5,92mm, lymphovascular invasion in 7% and perineural invasion in 5% of the cases. We found that tumors with a macroscopic diameter >20mm have a greater depth of invasion in comparison to SCCs with a smaller diameter. We found an incidence of local recurrence of 4,8%, lymph node metastases at 5,1%, far metastases in internal organs at 2,25% and mortality at 1,97%. Conclusion: Clinicohistopathological features of SCCs with related to recurrence, metastasis and mortality are localisation on the scalp, ears or lips, tumor size >20mm, depth of invasion >6mm, poor tumor cell differentiation, perineural and lymphovascular invasion, low or absent stromal lymphocyte infiltration.https://www.journal-imab-bg.org/issues-2023/issue4/2023vol29-issue4-5139-5144.pdfsquamous cell carcinoma of the skinhistopathologyrecurrencemetastasismortality |
| spellingShingle | Preslav Vasilev Savelina Popovska Milen Karaivanov Dobromir Dimitrov Ivelina Yordanova SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY Journal of IMAB squamous cell carcinoma of the skin histopathology recurrence metastasis mortality |
| title | SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY |
| title_full | SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY |
| title_fullStr | SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY |
| title_full_unstemmed | SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY |
| title_short | SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY |
| title_sort | squamous cell carcinoma of the skin a study of clinicohistopathological correlations predictive for recurrence metastasis and mortality |
| topic | squamous cell carcinoma of the skin histopathology recurrence metastasis mortality |
| url | https://www.journal-imab-bg.org/issues-2023/issue4/2023vol29-issue4-5139-5144.pdf |
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