The Evolution of Poxvirus Vaccines
After Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV), the causative agent of smallpox. Cowpox virus (CPXV) and horsepox virus (HSPV) were extensively used to this end, pas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-04-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/7/4/1726 |
| _version_ | 1819263243312431104 |
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| author | Lucas Sánchez-Sampedro Beatriz Perdiguero Ernesto Mejías-Pérez Juan García-Arriaza Mauro Di Pilato Mariano Esteban |
| author_facet | Lucas Sánchez-Sampedro Beatriz Perdiguero Ernesto Mejías-Pérez Juan García-Arriaza Mauro Di Pilato Mariano Esteban |
| author_sort | Lucas Sánchez-Sampedro |
| collection | DOAJ |
| description | After Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV), the causative agent of smallpox. Cowpox virus (CPXV) and horsepox virus (HSPV) were extensively used to this end, passaged in cattle and humans until the appearance of vaccinia virus (VACV), which was used in the final campaigns aimed to eradicate the disease, an endeavor that was accomplished by the World Health Organization (WHO) in 1980. Ever since, naturally evolved strains used for vaccination were introduced into research laboratories where VACV and other poxviruses with improved safety profiles were generated. Recombinant DNA technology along with the DNA genome features of this virus family allowed the generation of vaccines against heterologous diseases, and the specific insertion and deletion of poxvirus genes generated an even broader spectrum of modified viruses with new properties that increase their immunogenicity and safety profile as vaccine vectors. In this review, we highlight the evolution of poxvirus vaccines, from first generation to the current status, pointing out how different vaccines have emerged and approaches that are being followed up in the development of more rational vaccines against a wide range of diseases. |
| first_indexed | 2024-12-23T20:10:29Z |
| format | Article |
| id | doaj.art-94118db6b1774f7299da49867366013d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-23T20:10:29Z |
| publishDate | 2015-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-94118db6b1774f7299da49867366013d2022-12-21T17:32:49ZengMDPI AGViruses1999-49152015-04-01741726180310.3390/v7041726v7041726The Evolution of Poxvirus VaccinesLucas Sánchez-Sampedro0Beatriz Perdiguero1Ernesto Mejías-Pérez2Juan García-Arriaza3Mauro Di Pilato4Mariano Esteban5Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid-28049, SpainDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid-28049, SpainDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid-28049, SpainDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid-28049, SpainDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid-28049, SpainDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid-28049, SpainAfter Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV), the causative agent of smallpox. Cowpox virus (CPXV) and horsepox virus (HSPV) were extensively used to this end, passaged in cattle and humans until the appearance of vaccinia virus (VACV), which was used in the final campaigns aimed to eradicate the disease, an endeavor that was accomplished by the World Health Organization (WHO) in 1980. Ever since, naturally evolved strains used for vaccination were introduced into research laboratories where VACV and other poxviruses with improved safety profiles were generated. Recombinant DNA technology along with the DNA genome features of this virus family allowed the generation of vaccines against heterologous diseases, and the specific insertion and deletion of poxvirus genes generated an even broader spectrum of modified viruses with new properties that increase their immunogenicity and safety profile as vaccine vectors. In this review, we highlight the evolution of poxvirus vaccines, from first generation to the current status, pointing out how different vaccines have emerged and approaches that are being followed up in the development of more rational vaccines against a wide range of diseases.http://www.mdpi.com/1999-4915/7/4/1726poxvirusevolutionvaccines |
| spellingShingle | Lucas Sánchez-Sampedro Beatriz Perdiguero Ernesto Mejías-Pérez Juan García-Arriaza Mauro Di Pilato Mariano Esteban The Evolution of Poxvirus Vaccines Viruses poxvirus evolution vaccines |
| title | The Evolution of Poxvirus Vaccines |
| title_full | The Evolution of Poxvirus Vaccines |
| title_fullStr | The Evolution of Poxvirus Vaccines |
| title_full_unstemmed | The Evolution of Poxvirus Vaccines |
| title_short | The Evolution of Poxvirus Vaccines |
| title_sort | evolution of poxvirus vaccines |
| topic | poxvirus evolution vaccines |
| url | http://www.mdpi.com/1999-4915/7/4/1726 |
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