Spectroscopic analysis of metabolic profile in patients with relapsed multiple sclerosis
Introduction. Managing patients with relapsing-remitting multiple sclerosis (RMS) remains a pressing issue. Objective. To detect the reversible metabolic changes of the brain matter in patients with clinically exacerbated RMS and to follow them up after intravenous glucocorticoid (IVGC) treatment...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2022-12-01
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| Series: | Анналы клинической и экспериментальной неврологии |
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| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/841/pdf |
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| author | Galina G. Shkilnyuk Andrey A. Bogdan Elena V. Kryukova Andrey M. Petrov Tatyana N. Trofimova Igor D. Stolyarov |
| author_facet | Galina G. Shkilnyuk Andrey A. Bogdan Elena V. Kryukova Andrey M. Petrov Tatyana N. Trofimova Igor D. Stolyarov |
| author_sort | Galina G. Shkilnyuk |
| collection | DOAJ |
| description | Introduction. Managing patients with relapsing-remitting multiple sclerosis (RMS) remains a pressing issue.
Objective. To detect the reversible metabolic changes of the brain matter in patients with clinically exacerbated RMS and to follow them up after intravenous glucocorticoid (IVGC) treatment.
Materials and methods. Neurological examination and neuroimaging in the RMS patients included expanded disability status scale (EDSS) scoring, conventional brain magnetic resonance imaging (MRI), and proton nuclear magnetic resonance spectroscopy (1H-NMR spectroscopy) before and after IVGC treatment. Multivoxel 1H-NMR spectroscopy was used to assess metabolism in the centra semiovale and cingulate gyri.
Results. Based on the multivoxel 1H-NMR spectroscopy, relative metabolite concentrations in the grey and white matter statistically differed within the study cohort before and after the IVGC treatment. The N-acetylaspartate/choline ratio significantly recovered and the choline/creatine ratio decreased in the anterior cingulate gyri in 27% of patients. The brainstem function score significantly improved in the metabolic response group as compared to the non-metabolic response group.
Conclusion. We should study the potential predictors of RMS activity and the IVGC response to select the RMS relapses when pulse-therapy with IVGCs is definitely indicated. Spectroscopy may reveal RMS pathogenesis variability earlier than conventional MRI. |
| first_indexed | 2024-04-10T22:23:18Z |
| format | Article |
| id | doaj.art-9411c88593854ab8bcd7c94eb5ede829 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-10T22:23:18Z |
| publishDate | 2022-12-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-9411c88593854ab8bcd7c94eb5ede8292023-01-17T12:35:36ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332022-12-01164121710.54101/ACEN.2022.4.2616Spectroscopic analysis of metabolic profile in patients with relapsed multiple sclerosisGalina G. Shkilnyuk0https://orcid.org/0000-0001-7175-668XAndrey A. Bogdan1https://orcid.org/0000-0002-2836-1516Elena V. Kryukova2https://orcid.org/0000-0002-5395-9931Andrey M. Petrov3https://orcid.org/0000-0001-9648-5492Tatyana N. Trofimova4https://orcid.org/0000-0003-4871-2341Igor D. Stolyarov5https://orcid.org/0000-0001-8154-9107N.P. Beсhtereva Institute of Human Brain of the Russian Academy of SciencesN.P. Beсhtereva Institute of Human Brain of the Russian Academy of SciencesN.P. Beсhtereva Institute of Human Brain of the Russian Academy of SciencesN.P. Beсhtereva Institute of Human Brain of the Russian Academy of SciencesN.P. Beсhtereva Institute of Human Brain of the Russian Academy of SciencesN.P. Beсhtereva Institute of Human Brain of the Russian Academy of SciencesIntroduction. Managing patients with relapsing-remitting multiple sclerosis (RMS) remains a pressing issue. Objective. To detect the reversible metabolic changes of the brain matter in patients with clinically exacerbated RMS and to follow them up after intravenous glucocorticoid (IVGC) treatment. Materials and methods. Neurological examination and neuroimaging in the RMS patients included expanded disability status scale (EDSS) scoring, conventional brain magnetic resonance imaging (MRI), and proton nuclear magnetic resonance spectroscopy (1H-NMR spectroscopy) before and after IVGC treatment. Multivoxel 1H-NMR spectroscopy was used to assess metabolism in the centra semiovale and cingulate gyri. Results. Based on the multivoxel 1H-NMR spectroscopy, relative metabolite concentrations in the grey and white matter statistically differed within the study cohort before and after the IVGC treatment. The N-acetylaspartate/choline ratio significantly recovered and the choline/creatine ratio decreased in the anterior cingulate gyri in 27% of patients. The brainstem function score significantly improved in the metabolic response group as compared to the non-metabolic response group. Conclusion. We should study the potential predictors of RMS activity and the IVGC response to select the RMS relapses when pulse-therapy with IVGCs is definitely indicated. Spectroscopy may reveal RMS pathogenesis variability earlier than conventional MRI.https://annaly-nevrologii.com/journal/pathID/article/viewFile/841/pdfmultiple sclerosisrelapsemultivoxel 1nmr spectroscopyglucocorticoid treatmentpredictors |
| spellingShingle | Galina G. Shkilnyuk Andrey A. Bogdan Elena V. Kryukova Andrey M. Petrov Tatyana N. Trofimova Igor D. Stolyarov Spectroscopic analysis of metabolic profile in patients with relapsed multiple sclerosis Анналы клинической и экспериментальной неврологии multiple sclerosis relapse multivoxel 1nmr spectroscopy glucocorticoid treatment predictors |
| title | Spectroscopic analysis of metabolic profile in patients with relapsed multiple sclerosis |
| title_full | Spectroscopic analysis of metabolic profile in patients with relapsed multiple sclerosis |
| title_fullStr | Spectroscopic analysis of metabolic profile in patients with relapsed multiple sclerosis |
| title_full_unstemmed | Spectroscopic analysis of metabolic profile in patients with relapsed multiple sclerosis |
| title_short | Spectroscopic analysis of metabolic profile in patients with relapsed multiple sclerosis |
| title_sort | spectroscopic analysis of metabolic profile in patients with relapsed multiple sclerosis |
| topic | multiple sclerosis relapse multivoxel 1nmr spectroscopy glucocorticoid treatment predictors |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/841/pdf |
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