Screen and Identify Key Biomarkers Related to Bladder Cancer Through Multi-View Analysis
Accurate tumor staging is the premise andfoundation of precision medicine. This study aims to find the effectivebiomarkers in the staging process of bladder cancer tumors. First, screen keygene module related to the staging of bladder cancer. Then, taking the hubgenes in the key gene module as featu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Techland Publishing Group Limited
2021-03-01
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| Series: | Molecular Biology & Nanomedicine |
| Subjects: | |
| Online Access: | http://mbn.techlandgroup.com/index.php?c=articles&a=view&id=28 |
| _version_ | 1818725663076515840 |
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| author | Xiaxia Wang YanruiDing |
| author_facet | Xiaxia Wang YanruiDing |
| author_sort | Xiaxia Wang |
| collection | DOAJ |
| description | Accurate tumor staging is the premise andfoundation of precision medicine. This study aims to find the effectivebiomarkers in the staging process of bladder cancer tumors. First, screen keygene module related to the staging of bladder cancer. Then, taking the hubgenes in the key gene module as features, a stage prediction model isconstructed by logistic regression and stochastic gradient descent method. Itshows that themolecular combination of CTHRC1, COL6A3, TIMP2 andSULF1 can be used as an indicator for stage diagnosis. Importantly, the COL1A1is not only the pivot gene in the weighted gene co-expression network, but alsothe core of the protein-protein interaction network. And a set of single-cellRNA sequencing data in Gene Expression Omnibus (GEO) database is used to verifythe results. The consistent conclusions indicate that COL1A1 is a potentialoncogene and biomarker in the progression of bladder cancer, and can be used asa molecular target for the treatment of bladder cancer to slow the rate oftumor development. In addition, function and pathway enrichment analysis showthat focal adhesion is a crucial pathway in the tumor metastasis of bladdercancer, and members of the fibrous collagen family play an important role inthe proliferation and spread of tumor cells. The biomarkers and pathwaysidentified in this study provide an important basis for the determination ofpersonalized medical programs. |
| first_indexed | 2024-12-17T21:45:53Z |
| format | Article |
| id | doaj.art-9411cce4154a46ab971606a4632d082c |
| institution | Directory Open Access Journal |
| issn | 2707-4692 2707-4692 |
| language | English |
| last_indexed | 2024-12-17T21:45:53Z |
| publishDate | 2021-03-01 |
| publisher | Techland Publishing Group Limited |
| record_format | Article |
| series | Molecular Biology & Nanomedicine |
| spelling | doaj.art-9411cce4154a46ab971606a4632d082c2022-12-21T21:31:27ZengTechland Publishing Group LimitedMolecular Biology & Nanomedicine2707-46922707-46922021-03-012111110.37813/j.mbn.2707-4692.016Screen and Identify Key Biomarkers Related to Bladder Cancer Through Multi-View AnalysisXiaxia Wang0YanruiDing1School of Science, Jiangnan University, Wuxi214122, ChinaKey Laboratory of Industrial Biotechnology,Jiangnan University, Wuxi 214122, ChinaAccurate tumor staging is the premise andfoundation of precision medicine. This study aims to find the effectivebiomarkers in the staging process of bladder cancer tumors. First, screen keygene module related to the staging of bladder cancer. Then, taking the hubgenes in the key gene module as features, a stage prediction model isconstructed by logistic regression and stochastic gradient descent method. Itshows that themolecular combination of CTHRC1, COL6A3, TIMP2 andSULF1 can be used as an indicator for stage diagnosis. Importantly, the COL1A1is not only the pivot gene in the weighted gene co-expression network, but alsothe core of the protein-protein interaction network. And a set of single-cellRNA sequencing data in Gene Expression Omnibus (GEO) database is used to verifythe results. The consistent conclusions indicate that COL1A1 is a potentialoncogene and biomarker in the progression of bladder cancer, and can be used asa molecular target for the treatment of bladder cancer to slow the rate oftumor development. In addition, function and pathway enrichment analysis showthat focal adhesion is a crucial pathway in the tumor metastasis of bladdercancer, and members of the fibrous collagen family play an important role inthe proliferation and spread of tumor cells. The biomarkers and pathwaysidentified in this study provide an important basis for the determination ofpersonalized medical programs.http://mbn.techlandgroup.com/index.php?c=articles&a=view&id=28bladder cancerbiomarkers; focaladhesiontumor stagingcol1a1 |
| spellingShingle | Xiaxia Wang YanruiDing Screen and Identify Key Biomarkers Related to Bladder Cancer Through Multi-View Analysis Molecular Biology & Nanomedicine bladder cancer biomarkers; focaladhesion tumor staging col1a1 |
| title | Screen and Identify Key Biomarkers Related to Bladder Cancer Through Multi-View Analysis |
| title_full | Screen and Identify Key Biomarkers Related to Bladder Cancer Through Multi-View Analysis |
| title_fullStr | Screen and Identify Key Biomarkers Related to Bladder Cancer Through Multi-View Analysis |
| title_full_unstemmed | Screen and Identify Key Biomarkers Related to Bladder Cancer Through Multi-View Analysis |
| title_short | Screen and Identify Key Biomarkers Related to Bladder Cancer Through Multi-View Analysis |
| title_sort | screen and identify key biomarkers related to bladder cancer through multi view analysis |
| topic | bladder cancer biomarkers; focaladhesion tumor staging col1a1 |
| url | http://mbn.techlandgroup.com/index.php?c=articles&a=view&id=28 |
| work_keys_str_mv | AT xiaxiawang screenandidentifykeybiomarkersrelatedtobladdercancerthroughmultiviewanalysis AT yanruiding screenandidentifykeybiomarkersrelatedtobladdercancerthroughmultiviewanalysis |