The role of glycosylation in breast cancer metastasis and cancer control
AbstractGlycosylation and its correlation to the formation of remote metastasis in breast cancer had been an important scientific topic in the last 25 years. With the development of new analytical techniques new insights were gained on the mechanisms underlying metastasis formation and the role of a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00219/full |
| _version_ | 1811241965245693952 |
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| author | Alexandra eKölbl Ulrich eAnsdergassen Udo eJeschke |
| author_facet | Alexandra eKölbl Ulrich eAnsdergassen Udo eJeschke |
| author_sort | Alexandra eKölbl |
| collection | DOAJ |
| description | AbstractGlycosylation and its correlation to the formation of remote metastasis in breast cancer had been an important scientific topic in the last 25 years. With the development of new analytical techniques new insights were gained on the mechanisms underlying metastasis formation and the role of aberrant glycosylation within. Mucin-1 and Galectin were recognized as key players in glycosylation. Interestingly, aberrant carbohydrate structures seem to support the development of brain metastasis in breast cancer patients, as changes in glycosylation structures facilitate an overcoming of blood-brain barrier. Changes in the gene expression of glycosyltransferases are the leading cause for a modification of carbohydrate chains, so that also altered gene expression plays a role for glycosylation. In consequence, glycosylation and changes within can be useful for cancer diagnosis, determination of tumour stage and prognosis, but can as well be targets for therapeutic strategies. Thus, further research on this topic would worth wile for cancer combating. |
| first_indexed | 2024-04-12T13:43:49Z |
| format | Article |
| id | doaj.art-941373d26c524363a53c4fc359d60378 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T13:43:49Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-941373d26c524363a53c4fc359d603782022-12-22T03:30:45ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-10-01510.3389/fonc.2015.00219166524The role of glycosylation in breast cancer metastasis and cancer controlAlexandra eKölbl0Ulrich eAnsdergassen1Udo eJeschke2Ludwig Maximilians University of MunichLudwig Maximilians University of MunichLudwig Maximilians University of MunichAbstractGlycosylation and its correlation to the formation of remote metastasis in breast cancer had been an important scientific topic in the last 25 years. With the development of new analytical techniques new insights were gained on the mechanisms underlying metastasis formation and the role of aberrant glycosylation within. Mucin-1 and Galectin were recognized as key players in glycosylation. Interestingly, aberrant carbohydrate structures seem to support the development of brain metastasis in breast cancer patients, as changes in glycosylation structures facilitate an overcoming of blood-brain barrier. Changes in the gene expression of glycosyltransferases are the leading cause for a modification of carbohydrate chains, so that also altered gene expression plays a role for glycosylation. In consequence, glycosylation and changes within can be useful for cancer diagnosis, determination of tumour stage and prognosis, but can as well be targets for therapeutic strategies. Thus, further research on this topic would worth wile for cancer combating.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00219/fullCarbohydratesGlycosylationtherapybreast cancerprognosis |
| spellingShingle | Alexandra eKölbl Ulrich eAnsdergassen Udo eJeschke The role of glycosylation in breast cancer metastasis and cancer control Frontiers in Oncology Carbohydrates Glycosylation therapy breast cancer prognosis |
| title | The role of glycosylation in breast cancer metastasis and cancer control |
| title_full | The role of glycosylation in breast cancer metastasis and cancer control |
| title_fullStr | The role of glycosylation in breast cancer metastasis and cancer control |
| title_full_unstemmed | The role of glycosylation in breast cancer metastasis and cancer control |
| title_short | The role of glycosylation in breast cancer metastasis and cancer control |
| title_sort | role of glycosylation in breast cancer metastasis and cancer control |
| topic | Carbohydrates Glycosylation therapy breast cancer prognosis |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00219/full |
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