Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes.

Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes.

Gene expression is generally regulated by recruitment of transcription factors and RNA polymerase II (RNAP II) to specific sequences in the gene promoter region. The Integrator complex mediates processing of small nuclear RNAs (snRNAs) as well as the initiation and release of paused RNAP II at speci...

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Main Authors: Eva Gómez-Orte, Beatriz Sáenz-Narciso, Angelina Zheleva, Begoña Ezcurra, María de Toro, Rosario López, Irene Gastaca, Hilde Nilsen, María P Sacristán, Ralf Schnabel, Juan Cabello
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6390993?pdf=render

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