New-Onset Acute Interstitial Nephritis Post-SARS-CoV-2 Infection and COVID-19 Vaccination: A Panoramic Review
Abstract The 2019 coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has posed a considerable challenge to global healthcare. Acute interstitial nephritis (AIN) post SARS-CoV-2 infection and vaccination has been reported, but its clini...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer
2023-10-01
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| Series: | Journal of Epidemiology and Global Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s44197-023-00159-4 |
| _version_ | 1797416219536523264 |
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| author | Yu Wang Ling Yang Gaosi Xu |
| author_facet | Yu Wang Ling Yang Gaosi Xu |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | Abstract The 2019 coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has posed a considerable challenge to global healthcare. Acute interstitial nephritis (AIN) post SARS-CoV-2 infection and vaccination has been reported, but its clinical features and pathogenesis remained unclear. We reviewed so far the largest 22 cases of AIN post SARS-CoV-2 infection and 36 cases of AIN following COVID-19 vaccination. The onset of AIN was mainly related to messenger RNA vaccines (52.8%). Apart from fever, proteinuria (45.5%) was the main manifestation of AIN post SARS-CoV-2 infection, left acute kidney injury (AKI, 63.9%) in patients post COVID-19 vaccination. The potential mechanism of vaccination induced AIN was conjugating vaccines with proteins to form a hapten, which activated dendritic cells and promoted a cascade immunological reaction leading to AIN. |
| first_indexed | 2024-03-09T06:01:29Z |
| format | Article |
| id | doaj.art-9416f85f7a324206ab3abb9cc812e4b4 |
| institution | Directory Open Access Journal |
| issn | 2210-6014 |
| language | English |
| last_indexed | 2024-03-09T06:01:29Z |
| publishDate | 2023-10-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Epidemiology and Global Health |
| spelling | doaj.art-9416f85f7a324206ab3abb9cc812e4b42023-12-03T12:09:10ZengSpringerJournal of Epidemiology and Global Health2210-60142023-10-0113461563610.1007/s44197-023-00159-4New-Onset Acute Interstitial Nephritis Post-SARS-CoV-2 Infection and COVID-19 Vaccination: A Panoramic ReviewYu Wang0Ling Yang1Gaosi Xu2Department of Nephrology, Donghu District, the Second Affiliated Hospital of Nanchang UniversityDepartment of Health Management Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Nephrology, Donghu District, the Second Affiliated Hospital of Nanchang UniversityAbstract The 2019 coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has posed a considerable challenge to global healthcare. Acute interstitial nephritis (AIN) post SARS-CoV-2 infection and vaccination has been reported, but its clinical features and pathogenesis remained unclear. We reviewed so far the largest 22 cases of AIN post SARS-CoV-2 infection and 36 cases of AIN following COVID-19 vaccination. The onset of AIN was mainly related to messenger RNA vaccines (52.8%). Apart from fever, proteinuria (45.5%) was the main manifestation of AIN post SARS-CoV-2 infection, left acute kidney injury (AKI, 63.9%) in patients post COVID-19 vaccination. The potential mechanism of vaccination induced AIN was conjugating vaccines with proteins to form a hapten, which activated dendritic cells and promoted a cascade immunological reaction leading to AIN.https://doi.org/10.1007/s44197-023-00159-4Acute interstitial nephritisCOVID-19SARS-CoV-2Vaccination |
| spellingShingle | Yu Wang Ling Yang Gaosi Xu New-Onset Acute Interstitial Nephritis Post-SARS-CoV-2 Infection and COVID-19 Vaccination: A Panoramic Review Journal of Epidemiology and Global Health Acute interstitial nephritis COVID-19 SARS-CoV-2 Vaccination |
| title | New-Onset Acute Interstitial Nephritis Post-SARS-CoV-2 Infection and COVID-19 Vaccination: A Panoramic Review |
| title_full | New-Onset Acute Interstitial Nephritis Post-SARS-CoV-2 Infection and COVID-19 Vaccination: A Panoramic Review |
| title_fullStr | New-Onset Acute Interstitial Nephritis Post-SARS-CoV-2 Infection and COVID-19 Vaccination: A Panoramic Review |
| title_full_unstemmed | New-Onset Acute Interstitial Nephritis Post-SARS-CoV-2 Infection and COVID-19 Vaccination: A Panoramic Review |
| title_short | New-Onset Acute Interstitial Nephritis Post-SARS-CoV-2 Infection and COVID-19 Vaccination: A Panoramic Review |
| title_sort | new onset acute interstitial nephritis post sars cov 2 infection and covid 19 vaccination a panoramic review |
| topic | Acute interstitial nephritis COVID-19 SARS-CoV-2 Vaccination |
| url | https://doi.org/10.1007/s44197-023-00159-4 |
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