Association of GFR, Fiber-Rich Regimen and Metabolic Syndrome With Elevated C-Reactive Protein Levels: Results of a Multicenter National Survey
The present study investigates the association of cardiovascular risk factors such as metabolic syndrome (MetS), fiber-rich regimen, and Glomerular Filtration Rate (GFR) with elevated high-sensitivity C-reactive protein (hsCRP) levels. We designed a cross-sectional study based on data of the third N...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2020-08-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/8214 |
| _version_ | 1818759511727407104 |
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| author | Zahra Hosseini Saeed Ghodsi Seyed-Ali Sadre-Bafghi Mehrnaz Mohebi Alipasha Meisamie Saeed Tofighi Hamidreza Soleimani |
| author_facet | Zahra Hosseini Saeed Ghodsi Seyed-Ali Sadre-Bafghi Mehrnaz Mohebi Alipasha Meisamie Saeed Tofighi Hamidreza Soleimani |
| author_sort | Zahra Hosseini |
| collection | DOAJ |
| description | The present study investigates the association of cardiovascular risk factors such as metabolic syndrome (MetS), fiber-rich regimen, and Glomerular Filtration Rate (GFR) with elevated high-sensitivity C-reactive protein (hsCRP) levels. We designed a cross-sectional study based on data of the third National Survey of non-communicable diseases (SuRFNCD-2007); among 2125, Iranian adults (1168 women) aged 25-64 years. Demographic and anthropometric characteristics were collected. Biochemical assessments, were determined on venous blood samples. Quantitative highly sensitive CRP was measured via enzyme-linked immunoassay. Elevated CRP was defined as values above 3 mg/l. Metabolic syndrome was defined according to the ATP III (Adult Treatment Panel III report, 2005). GFR was calculated with the MDRD formula. Multivariable logistic regression accompanied by complex sample survey analysis, including stratified weighting, were recruited. The fiber-rich regimen was determined by the daily consumption of more than five units of vegetables or fruits. Mean age of the population was 39.4±4.5 years. Adjusted odds ratios for prediction of high CRP pertaining to High LDL, Low Physical activity, BUN, MetS ATP III, Declined GFR (per 30 units reduction), optimal Fiber intake, and Current Smoking were calculated. Corresponding values with 95 % CI were 1.36 (1.04-1.85), 1.31(1.11-4.20), 1.04(1.04-1.12), 1.47 (1.04-2.09), 1.22 (1.11-3.36), 0.84 (0.87-1.48), 1.74 (0.39-1.38), respectively. We figured out that MetS, declined GFR in early stages of CKD, and low physical activity were related to high inflammatory state, while fiber-rich regimen decreased the likelihood of high CRP in smokers. |
| first_indexed | 2024-12-18T06:43:54Z |
| format | Article |
| id | doaj.art-941715cddedd4eec9fe8d496b1156696 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-18T06:43:54Z |
| publishDate | 2020-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-941715cddedd4eec9fe8d496b11566962022-12-21T21:17:34ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942020-08-0158510.18502/acta.v58i5.3953Association of GFR, Fiber-Rich Regimen and Metabolic Syndrome With Elevated C-Reactive Protein Levels: Results of a Multicenter National SurveyZahra Hosseini0Saeed Ghodsi1Seyed-Ali Sadre-Bafghi2Mehrnaz Mohebi3Alipasha Meisamie4Saeed Tofighi5Hamidreza Soleimani6Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Preventive Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, IranThe present study investigates the association of cardiovascular risk factors such as metabolic syndrome (MetS), fiber-rich regimen, and Glomerular Filtration Rate (GFR) with elevated high-sensitivity C-reactive protein (hsCRP) levels. We designed a cross-sectional study based on data of the third National Survey of non-communicable diseases (SuRFNCD-2007); among 2125, Iranian adults (1168 women) aged 25-64 years. Demographic and anthropometric characteristics were collected. Biochemical assessments, were determined on venous blood samples. Quantitative highly sensitive CRP was measured via enzyme-linked immunoassay. Elevated CRP was defined as values above 3 mg/l. Metabolic syndrome was defined according to the ATP III (Adult Treatment Panel III report, 2005). GFR was calculated with the MDRD formula. Multivariable logistic regression accompanied by complex sample survey analysis, including stratified weighting, were recruited. The fiber-rich regimen was determined by the daily consumption of more than five units of vegetables or fruits. Mean age of the population was 39.4±4.5 years. Adjusted odds ratios for prediction of high CRP pertaining to High LDL, Low Physical activity, BUN, MetS ATP III, Declined GFR (per 30 units reduction), optimal Fiber intake, and Current Smoking were calculated. Corresponding values with 95 % CI were 1.36 (1.04-1.85), 1.31(1.11-4.20), 1.04(1.04-1.12), 1.47 (1.04-2.09), 1.22 (1.11-3.36), 0.84 (0.87-1.48), 1.74 (0.39-1.38), respectively. We figured out that MetS, declined GFR in early stages of CKD, and low physical activity were related to high inflammatory state, while fiber-rich regimen decreased the likelihood of high CRP in smokers.https://acta.tums.ac.ir/index.php/acta/article/view/8214Cardiovascular diseaseC-reactive proteinMetabolic syndromeInflammationGlomerular filtration rate (GFR)Fiber intake |
| spellingShingle | Zahra Hosseini Saeed Ghodsi Seyed-Ali Sadre-Bafghi Mehrnaz Mohebi Alipasha Meisamie Saeed Tofighi Hamidreza Soleimani Association of GFR, Fiber-Rich Regimen and Metabolic Syndrome With Elevated C-Reactive Protein Levels: Results of a Multicenter National Survey Acta Medica Iranica Cardiovascular disease C-reactive protein Metabolic syndrome Inflammation Glomerular filtration rate (GFR) Fiber intake |
| title | Association of GFR, Fiber-Rich Regimen and Metabolic Syndrome With Elevated C-Reactive Protein Levels: Results of a Multicenter National Survey |
| title_full | Association of GFR, Fiber-Rich Regimen and Metabolic Syndrome With Elevated C-Reactive Protein Levels: Results of a Multicenter National Survey |
| title_fullStr | Association of GFR, Fiber-Rich Regimen and Metabolic Syndrome With Elevated C-Reactive Protein Levels: Results of a Multicenter National Survey |
| title_full_unstemmed | Association of GFR, Fiber-Rich Regimen and Metabolic Syndrome With Elevated C-Reactive Protein Levels: Results of a Multicenter National Survey |
| title_short | Association of GFR, Fiber-Rich Regimen and Metabolic Syndrome With Elevated C-Reactive Protein Levels: Results of a Multicenter National Survey |
| title_sort | association of gfr fiber rich regimen and metabolic syndrome with elevated c reactive protein levels results of a multicenter national survey |
| topic | Cardiovascular disease C-reactive protein Metabolic syndrome Inflammation Glomerular filtration rate (GFR) Fiber intake |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/8214 |
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